A5010979808- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Biosimilars and Bioanalytical Methods
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cell death mechanisms and regulation
- Glycosylation and Glycoproteins Research
Cancer Center Amsterdam
2011-2025
Vrije Universiteit Amsterdam
2006-2025
Amsterdam University Medical Centers
2019-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2024
Hovon
2022-2023
University of Amsterdam
1992-2023
The University of Texas MD Anderson Cancer Center
2023
University Medical Center
2012-2023
National Cancer Centre Japan
2023
Dutch Cancer Society
2021
The human T cell Ag CD27 belongs to a recently defined family of surface receptors, including the nerve growth factor receptor, two distinct tumor necrosis and B specific molecule CD40. On resting cells, is transmembrane homodimer with subunits 50 55 kDa (p55). activation via TCR/CD3 complex causes strong enhancement p55 expression. Concomitantly, an alternative form molecular mass 28 32 (p32) appears at surface. With use ELISA, we here show that soluble (sCD27) can be detected in...
Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine can create immune suppression. Recently, blasts patients with acute myeloid leukemia were shown to 2,3-dioxygenase. We determined INDO (encoding gene 2,3-dioxygenase) mRNA expression in leukemic 286 by gene-expression profiling. Results validated quantitative polymerase chain reaction analysis...
Abstract Tetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell malignancies. Although complement-dependent cytotoxicity (CDC) is powerful Fc-mediated effector function killing hematological cancer cells, CD37-specific antibodies are generally poor inducers of CDC. To enhance CDC, the E430G mutation was introduced into humanized monoclonal IgG1 to drive more efficient IgG hexamer formation through intermolecular Fc-Fc interactions after cell surface...
Abstract Epcoritamab (DuoBody-CD3xCD20, GEN3013) is a novel bispecific IgG1 antibody redirecting T-cells toward CD20 + tumor cells. Here, we assessed the preclinical efficacy of epcoritamab against primary cells present in lymph node biopsies from newly diagnosed (ND) and relapsed/refractory (RR) B-NHL patients. In presence healthy donor, demonstrated potent activity cells, irrespective prior treatments, including mAbs. Median lysis 65, 74, 84% were achieved diffuse large B-cell lymphoma ( n...
Convolutional neural networks (CNNs) may improve response prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to investigate the feasibility a CNN using maximum intensity projection (MIP) images from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) baseline scans predict probability time-to-progression (TTP) within 2 years and compare it with International Prognostic Index (IPI), i.e. clinically used score. 296 DLBCL 18F-FDG PET/CT collected...
Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine can create immune suppression. Recently, blasts patients with acute myeloid leukemia were shown to 2,3-dioxygenase. We determined INDO (encoding gene 2,3-dioxygenase) mRNA expression in leukemic 286 by gene-expression profiling. Results validated quantitative polymerase chain reaction analysis...
An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. On the one hand an skewed T-cell repertoire reported, on other hand, decreased natural killer cell function found. Immune activation could reflect undesired autoimmune reactions against normal hematopoietic precursor cells as well effective immune-surveillance dysplastic clones.We have investigated effector (lymphocyte...
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many acquire resistance, demonstrating need new and drugs. We previously demonstrated that natural process of hexamer formation on targeted cells allows optimal induction complement-dependent cytotoxicity. Complement-dependent cytotoxicity can be potentiated by introducing a single point mutation such as E430G in IgG Fc domain enhances intermolecular Fc-Fc interactions...
TPS7578 Background: The nearly 40% of patients (pts) with large B-cell lymphoma (LBCL) who are refractory to or relapse after current first-line (1L) standard-of-care (SOC) regimens, such as R-CHOP (rituximab [R] + cyclophosphamide [C], doxorubicin [H], vincristine [O], and prednisone [P]) DA-EPOCH-R (dose-adjusted etoposide [DA-E]), have poor prognoses. High International Prognostic Index (IPI) score the subtype high-grade (HGBL) associated shorter progression-free overall survival (PFS OS;...
Only a small number of patients with aggressive B-cell lymphoma take part in clinical trials, and elderly particular are under-represented. Therefore, we studied data the population-based nationwide Netherlands Cancer Registry to determine trends incidence, treatment survival an unselected patient population. We included all aged 15 years older newly diagnosed diffuse large or Burkitt period 1989–2010 mantle cell 2001–2010, follow up until February 2013. examined first-line survival....
Burkitt lymphoma is an aggressive B cell malignancy accounting for 1–2% of all adult lymphomas. Treatment with dose-intensive, multi-agent chemotherapy effective but associated considerable toxicity. In this observational study, we compared real-world efficacy, toxicity, and costs four frequently employed treatment strategies lymphoma: the Lymphome Malins (LMB), Berlin-Frankfurt-Münster (BFM), HOVON, CODOX-M/IVAC regimens. We collected data from 147 patients treated in eight referral...
Patients with MYC-rearrangement positive large B-cell lymphoma (MYC+ LBCL) have an inferior prognosis following standard first-line therapy rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) as compared to patients without MYC rearrangement. Although intensive chemotherapy regimens yield higher remission rates, toxicity remains a concern. Lenalidomide is oral immunomodulatory drug which downregulates its target genes thereby providing support using lenalidomide...
For elderly frail patients with diffuse large B-cell lymphoma (DLBCL), an attenuated chemo-immunotherapy strategy of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-miniCHOP) was introduced as a treatment option from 2014 onward in the Netherlands. Although R-miniCHOP is more tolerable, reduction chemotherapy could negatively affect survival compared to R-CHOP. The aim this analysis assess treated DLBCL ≥65 years, newly diagnosed 2014-2020, who received ≥1 cycle or...
7015 Background: Improving the safety of epcoritamab by reducing incidence and severity CRS ICANS may enhance its accessibility reduce healthcare resource utilization. In pivotal EPCORE NHL-1 study (phase 1/2; NCT03625037), treatment (tx) led to high overall (ORR) complete response (CR) rates 82% 63%, respectively, in a cohort patients (pts) with R/R FL. Safety was manageable, events being primarily low grade. Here we report first results from fully enrolled FL C1 OPT investigating...