A5007089003- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory Bowel Disease
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Adolescent and Pediatric Healthcare
- Epilepsy research and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Microscopic Colitis
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
Emma Kinderziekenhuis
2017-2023
Amsterdam University Medical Centers
2019-2023
University of Amsterdam
2019-2023
Sanquin
2019-2022
Amsterdam UMC Location University of Amsterdam
2014-2017
Fundación Juan March
2017
Summary Most sickle cell disease (SCD) patients rely on blood transfusion as their main treatment strategy. However, frequent poses the risk of alloimmunization. On average, 30% SCD will alloimmunize while other patient groups form antibodies less frequently. Identification genetic markers may help to predict which are at alloantibodies. The aim this study was evaluate whether variations in Toll‐like receptor pathway or genes previously associated with antibody‐mediated conditions red (RBC)...
Intravenous fluid therapy (IV-FT) is routinely used in the treatment of vaso-occlusive crises (VOCs), as dehydration possibly promotes and sustains erythrocyte sickling. Patients with sickle cell disease (SCD) are at risk developing diastolic dysfunction overload due to IV-FT. However, data on adverse effects IV-FT for VOC sparse. We aimed evaluate incidence factors patients SCD. Consecutive hospitalisations treated between September 2016 2018 were retrospectively analysed. The median...
Summary Delayed haemolytic transfusion reaction (DHTR) is a potentially life‐threatening complication of red blood cell (RBC) transfusions in sickle disease (SCD) and classically induced by reactivation previously formed antibodies. Improved antigenic matching has reduced alloimmunization may reduce DHTR risk. We conducted retrospective cohort study to investigate the incidence rate SCD patients receiving extended matched units (ABO/RhDCcEe/K/Fy /Jk b /S). Occasional episodes (OTE) between...
ABSTRACT Objectives: The degree to which children and adolescents with inflammatory bowel disease (IBD) complete clinical activity indices in accordance their physician is indefinite. Therefore, we investigated the agreement between patient‐ physician‐based a previous diagnosis of IBD. Methods: In this cross‐sectional study, IBD patients (8–18 years) were included prospectively. Patients completed patient‐based short Pediatric Crohn's Disease Activity Index (shPCDAI) for Crohn or Ulcerative...
Abstract Background Red blood cell (RBC) transfusions are an important treatment modality for patients with sickle disease (SCD) and β‐thalassemia. A subgroup of these relies on a chronic RBC transfusion regimen. Little is known about survival (RCS) the transfused allogeneic RBCs. In this study, we aimed to study RCS kinetics RBCs in SCD β‐thalassemia investigate factors that determine RCS. Methods Materials We performed prospective cohort fourteen adults receiving influence donor patient...