A5007280160- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Cystic Fibrosis Research Advances
- Biochemical Analysis and Sensing Techniques
- Fungal Infections and Studies
- Olfactory and Sensory Function Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Mesenchymal stem cell research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ocular Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Fatty Acid Research and Health
- Neutropenia and Cancer Infections
- Biosensors and Analytical Detection
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Indoor Air Quality and Microbial Exposure
- Bacterial Identification and Susceptibility Testing
- Fibroblast Growth Factor Research
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
University of Amsterdam
2014-2021
Amsterdam UMC Location University of Amsterdam
2014-2019
University Medical Center Utrecht
2011-2017
Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy inhaled corticosteroids (ICS) targets inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable loss control.To determine whether organic compounds (VOCs) as measured by gas-chromatography/mass-spectrometry (GC/MS)...
We performed a prospective study in patients with chemotherapy induced febrile neutropenia to investigate the diagnostic value of low-dose computed tomography compared standard chest radiography. The aim was compare both modalities for detection pulmonary infections and explore performance early invasive fungal disease. remained blinded during study. A consensus diagnosis fever episode made by an expert panel used as reference standard. included 67 consecutive on first day neutropenia....
Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by vitro cultured, clinical Aspergillus isolates using gas chromatography–mass spectrometry (GC-MS). Three and a reference strain were cultured while conidiation was prevented. Headspace samples analyzed standardized method. Breath patients from which cultures obtained checked for VOCs found vitro. Each isolate produced distinct profile....
Systemic inflammatory response syndrome (SIRS) is observed during critical illness in most patients. It defined by a clinical definition. The composition of volatile organic compounds (VOCs) exhaled breath may change SIRS and thus serve as diagnostic tool. We investigated whether VOCs can biomarker for human model endotoxemia. Eighteen healthy volunteers received 2 ng Eschericia coli lipopolysaccharide (LPS) kg−1 body weight intravenously. Venous blood were collected before infusion LPS...
<i>Pseudomonas aeruginosa</i> (<i>PA</i>) is one of the most pathogenic bacteria infecting airways patients with cystic fibrosis (CF). Sputum culture gold standard for detecting <i>PA</i>. However, this method time-consuming. In study we hypothesized that volatile organic compounds (VOCs) in exhaled breath can discriminate between <i>PA</i> infected and non-infected CF patients. Design: Cross-sectional baseline analysis longitudinal cohort study. We collected air both pediatric adult without...
<b>Introduction:</b> Exacerbations/loss of control (LOC) represent the major burden in asthma care and management. These events are clinically manifested by changes symptoms lung function, which associated with biomarkers related to airway pathophysiology. Direct assessment exhaled air volatile organic compounds (VOCs) could capture exacerbation/LOC changed metabolomic fingerprints this provide a Point Of Care diagnostic poor perceivers exacerbation symptoms. <b>Aims:</b> To identify...
10532 Background: Environment-mediated resistance to chemotherapy is emerging as a cause of treatment failure. In mouse models, we showed that mesenchymal stem cells (MSCs) are activated by platinum-based secrete two unique platinum-induced fatty acids (PIFAs): KHT(n-6) and 16:4(n-3) which induce broad spectrum chemotherapies. These also present in various food products supplements. Fish oil some algae frequently used cancer patients because their perceived positive health effects....
<b>Objectives:</b> In cystic fibrosis (CF), <i>Pseudomonas aeruginosa</i> (<i>PA</i>) is an important respiratory pathogen. Routine microbial surveillance time-consuming and requires expectorated sputum. Volatile organic compounds (VOCs) in exhaled breath may be indicative of <i>PA</i> colonization. We aimed to 1) identify VOCs associated with PA literature 2) perform targeted analysis recognize positive CF patients non-invasively. <b>Methods:</b> This study consisted a review for VOC...