A5088443745- Multiple Myeloma Research and Treatments
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Degradation and Inhibitors
- Neuroscience and Neuropharmacology Research
- Dietary Effects on Health
- Cassava research and cyanide
- Blood Coagulation and Thrombosis Mechanisms
- Artificial Intelligence in Healthcare
- Folate and B Vitamins Research
- Antimicrobial Resistance in Staphylococcus
- Pharmacogenetics and Drug Metabolism
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Research on Leishmaniasis Studies
- Helminth infection and control
- Adipose Tissue and Metabolism
- Carcinogens and Genotoxicity Assessment
- Eicosanoids and Hypertension Pharmacology
- Biomedical Text Mining and Ontologies
- Anesthesia and Sedative Agents
Vrije Universiteit Amsterdam
2023-2024
Cancer Center Amsterdam
2023-2024
Amsterdam University Medical Centers
2023-2024
University of Amsterdam
2023
Universitair Ziekenhuis Brussel
1997
Ghent University Hospital
1997
National Institute for Public Health and the Environment
1996
Netherlands Consortium for Healthy Ageing
1992-1995
Leiden University
1987-1994
Netherlands Organisation for Applied Scientific Research
1990
1. The pharmacokinetics of R(+)‐bupivacaine and S(‐)‐bupivacaine were investigated following a 10 min intravenous infusion the racemate (dose 30 mg) in healthy males. 2. fractions unbound R(+)‐ pre‐dose plasma determined for each subject after vitro addition rac‐bupivacaine (concentration enantiomer: approximately 300 ng ml‐1). 3. total clearance (mean +/‐ s.d.: 0.395 0.076 l min‐1) was greater (P < 0.0001) than that (0.317 0.067 min‐1). volumes distribution at steady state (84 29 l)...
Teclistamab, a T-cell redirecting bispecific antibody (BsAb) targeting B-cell maturation antigen (BCMA), has marked activity in heavily pretreated multiple myeloma (MM) patients (overall response rate: 63.0%; at least very good partial [≥VGPR]: 59.4%; median progression-free survival [PFS]: 11.3 months).1, 2 Teclistamab treatment induces activation and production of proinflammatory cytokines such as interleukin-6 (IL-6).3 This increase frequently results systemic inflammatory syndrome...
Pharmacokinetics and safety of a hydroxy-beta-propyl solution itraconazole were assessed in 16 patients an intensive care unit. On the first 2 days, four 1-h infusions 200 mg given at 0, 8, 24, 32 h. From day 3 to 7, inclusive, single infusion was daily. The intravenous (i.v.) treatment directly followed by repeated administrations oral dosage either once daily or twice (b.i.d.). During i.v. treatment, steady-state concentrations hydroxy-itraconazole plasma reached within 48 96 h,...
In 2015, the International Myeloma Working Group (IMWG) introduced a frailty index (IMWG-FI), as means to quantify fragility of patients with multiple myeloma (MM). This categorizes into three groups: fit, intermediate-fit, or frail, based on age, comorbidities, and level assistance for (instrumental) daily activities ((i)ADL). Scores IMWG-FI range from zero five points. A score designates one indicates between two denotes frail. Three-year overall survival rates were 84% in fit patients,...
Correctly structured problem lists in electronic health records (EHRs) offer major benefits to patient care. Without lists, diagnosis information is often scatteredly documented free text, which may contribute errors and inefficient retrieval. This study aims assess whether EHRs with correctly result better faster clinical decision-making compared non-curated lists.Two versions of two (A B) were created an EHR training environment: one version included coded on the list ("correctly list"),...
Abstract1. The toxicokinetics of [3H]-α-solanine after oral (p.o.) and intravenous (i.v.) administration in rat hamster were studied, order to decide which is the most appropriate model risk assessment studies. i.v. Dose was 54 βg/kg; dose 170 βg/kg.2. After Administration, total radioactivity blood comparable hamster. However, clearance from plasma more effective than half-lives distribution terminal phase unchanged α-solanine not different between hamster, whereas systemic metabolic were,...
In order to study the metabolic activities of different P-450 enzymes in male Brown Norway rats, formation rates antipyrine (AP) metabolites and theophylline (TH) clearance were determined. rats are often used studies concerning influence age on liver function. Experiments performed after simultaneous iv administration two compounds with without 3-methylcholanthrene (3-MC) pretreatment. Pharmacokinetic data both AP TH significantly influenced by 3-MC Metabolic increased from 6.8 +/- 1.0...
The influence of aging on the metabolism antipyrine (AP) and hexobarbital enantiomers (R-HB S-HB) with without phenobarbital (PB) induction was investigated in a longitudinal study rats aged 6, 12, 24 30 months. metabolic clearances AP (Clm AP), R-HB R-HB) S-HB were used as indicators for P450 enzyme activities vivo. This also included assessment formation three metabolites, 3-hydroxymethylantipyrine (Cl-->HMA), 4-hydroxyantipyrine (Cl-->OHA) norantipyrine (Cl-->NORA). Aging appeared to have...
A bioequivalence study with three penicillin/dihydrostreptomycin fixed combination products for intramuscular administration was performed in dairy calves. In addition to plasma concentrations of penicillin and dihydrostreptomycin, creatine phosphokinase were determined during a period 72 h after the drug products. Considerable differences observed pharmacokinetics from Although extent absorption similar all products, one product showed significantly slower release site injection. Except AUC...
The influence of ageing and dietary restriction (DR) on the in vivo activities different P450 enzymes was studied longitudinally female BN/BiRij rats. For this purpose, antipyrine (AP) theophylline (TH) were used as substrates. metabolic clearances AP (CIm AP) TH TH) indicators for enzyme vivo. Therefore, we also included assessment formation three metabolites, i.e., 3-hydroxymethylantipyrine (CI-->HMA), 4-hydroxyantipyrine (CI-->OHA) norantipyrine (CI-->NORA). Ninety, 50 10% survival times...
Xamoterol has a phenolic hydroxyl group at which both sulphation and glucuronidation may occur. In the rat in vivo it is almost exclusively glucuronidated. bile glucuronide conjugate only metabolite of xamoterol. urine equal amounts unchanged xamoterol are present, together with small amount sulphate (approx. 1% dose). The t1/2 excretion was same as for urine. urinary longer than that its biliary excretion. isolated perfused liver also exclusive metabolic pathway. extraction ratio by approx....
The bioavailability of penicillin and dihydrostreptomycin from three penicillin/ aminoglycoside fixed combination products for intramuscular injection was investigated in a four‐way, randomized, crossover experiment rabbits. Attention is focused on bioequivalence based plasma concentration vs. time profiles to study whether the rabbit good model detect differences vivo delivery and/or after administration different products. In all products, present as suspension. Although extent absorption...