A5102946372- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Drug Transport and Resistance Mechanisms
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Diabetes and associated disorders
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tumors and Oncological Cases
- Blood disorders and treatments
- Cancer therapeutics and mechanisms
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
Maasstad Ziekenhuis
2018-2025
Erasmus MC Cancer Institute
2015
Erasmus MC
2005-2014
Erasmus University Rotterdam
2003
To the Editor: Chronic lymphocytic leukemia (CLL) is most common in Western world, with a median age at diagnosis of 72 years. An estimated 2% patients are females childbearing age. CLL cases during pregnancy rare and associated many complications. Although implications management have been discussed previously, issues related to noninvasive prenatal testing (NIPT) often overlooked [1]. Various chromosomal changes CLL, deletion long arm chromosome 13 position q14 (deletion 13q14) being...
A 61-year-old man, with no significant medical history, presented a six-month history of fatigue, pruritus, night sweats, and weight loss. Physical examination revealed erythroderma generalized lymphadenopathy. Laboratory tests showed prominent eosinophilia (white blood cell count 10.6 × 109/L, eosinophils 2.9 109/L). There was lymphocytosis (lymphocyte 1.1 Lactate dehydrogenase (LDH) elevated at 469 U/L. peripheral smear (top left top right, May–Grünwald–Giemsa [MGG], ×100 objective)...
Preclinical data suggests that protein and calorie restriction (PCR) might improve treatment tolerability without impairing antitumor efficacy. Therefore, we have studied the influence of PCR on irinotecan pharmacokinetics toxicity. In this crossover trial, patients with liver metastases solid tumors were included randomized to preceded by 5 days (~ 30% caloric ~ 70% restriction) during first cycle a second normal diet or vice versa. Pharmacokinetic blood sampling biopsies both healthy...
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation thrive because constitutive activation the STAT3 ERK pathway. Notably, in 40% patients, is due to activating mutations, whereas 60% this unknown. As miRNAs are amongst most potent regulators health disease, we hypothesized that aberrant miRNA expression could contribute dysregulation these pathways. sequencing leukemia cases aged-matched healthy control TEMRA revealed overexpression miR-181a. Furthermore,...
A 70-year-old woman with a history of successfully resected pancreatic cancer 10 years ago presented dyspnea and fever. Laboratory tests showed leukocytosis (white cell count 20.8 × 109/L) elevated C-reactive protein (87 mg/L) normal hemoglobin concentration (Hb) (137 g/L) platelet (242 109/L). Computed tomography identified hepatic abscess. The abscess was drained ceftriaxone-metronidazole administered intravenously. Sixteen hours after presentation, the patient's condition deteriorated, Hb...
Patients with MYC rearranged (MYC-R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated and yields similar complete metabolic remission rates as more intensive chemotherapy regimens literature. In parallel this interventional trial, prospective observational screening cohort (HOVON-900) was open which identified all newly diagnosed MYC-R DLBCL...
Acquired haemophilia A after alemtuzumab therapyTreatment with leads to a prolonged depletion of T-and B cells, natural killer dendritic cells and monocytes. 1Alemtuzumab therapy is associated secondary auto-immune disorders, including thyroid disease, immune throm
A 61-year-old woman was referred because of bone pain and unilateral proptosis the left eye (Figure 1A) with diplopia but without vision loss. Elevation, adduction abduction were impaired. The plica thickened a distention palpable above eye. Fundoscopy showed no papilledema or vascular abnormalities. Computed tomography imaging large intraorbital mass 1B) extensive lytic skeletal lesions. Peripheral blood (PB) examination hypercalcaemia, anaemia, thrombocytopenia leukocytosis (28.8 × 109/L)....