A5016958906- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Multiple and Secondary Primary Cancers
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Abdominal vascular conditions and treatments
- Aortic Thrombus and Embolism
- Vascular anomalies and interventions
- Surgical Simulation and Training
- Nutrition and Health in Aging
- Power System Optimization and Stability
- Innovations in Medical Education
- Cardiovascular Syncope and Autonomic Disorders
- Magnetic Properties and Applications
- Advanced MRI Techniques and Applications
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
University Medical Center Utrecht
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Utrecht University
2017-2024
St. Antonius Ziekenhuis
2024
Moscow Clinical Scientific Center
2018
JDSU (United States)
2018
Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) the primary tumor upon histopathological evaluation resection specimen. The aim this study is to develop model that predicts probability pCR nCRT in cancer, based on diffusion-weighted magnetic resonance imaging (DW-MRI), dynamic contrast-enhanced (DCE-MRI) and 18F-fluorodeoxyglucose positron emission tomography with computed (18F-FDG...
Formulae display:?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax order to improve their display. Uncheck the box turn off. This feature requires Javascript. Click on a formula zoom.
Purpose: To investigate the impact of paratracheal lymphadenectomy on survival in patients undergoing an esophagectomy for cancer. The secondary objective was to assess effect short-term outcomes. Methods: Between 2011-2017, with esophageal or gastroesophageal junction carcinoma treated elective transthoracic two-field were included from Dutch Upper Gastro-intestinal Cancer Audit registry. After 1:1 propensity score matching and without within histologic subgroups, outcomes overall compared...
This study was conducted in order to determine the optimal timing of diffusion-weighted magnetic resonance imaging (DW-MRI) for prediction pathologic complete response (pCR) neoadjuvant chemoradiotherapy (nCRT) esophageal cancer.
Anastomotic leakage (AL) after esophagectomy is the most impactful complication esophagectomy. Ischemic conditioning (ISCON) of stomach >14 days prior to might reduce incidence AL. The current trial was conducted prospectively investigate safety and feasibility laparoscopic ISCON in selected patients. This international multicenter included patients with esophageal cancer at high risk for AL major calcifications thoracic aorta or a stenosis celiac trunk. Patients underwent by occlusion left...
Occult metastases are detected in 10-15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult with potentially resectable Model development was performed within the Dutch Pancreatic Cancer Audit, including all operated cancer (January 2013-December 2017). Multivariable logistic regression analysis based on Akaike Information Criteria intraoperative pathologically proven as outcome. The cohort from University...
New-onset atrial fibrillation (AF) is frequently observed following esophagectomy and may predict other complications. The aim of the current study was to determine association between, possible predictive value of, new-onset AF infectious complications esophagectomy. Consecutive patients who underwent elective with curative intent for esophageal cancer between 2004 2016 in University Medical Center Utrecht were included from a prospective database. date diagnosis analysis retrospectively...
Background: Neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer causes tumor regression during treatment. Tumor can induce changes in the thoracic anatomy, with smaller target volumes and displacement of organs at risk (OARs) surrounding as a result. Adaptation radiotherapy treatment plan according to volumetric might reduce radiation dose OARs, while maintaining adequate coverage. Data on magnitude its impact anatomy is scarce. The aim this study was assess primary nCRT based weekly...
Abstract Background The role of 18 F-fluorodeoxyglucose positron emission tomography with computed (FDG-PET/CT) and staging laparoscopy (SL) has increased in the preoperative gastric cancer. Dutch national guidelines have recommended use FDG-PET/CT SL for patients locally advanced tumors since July 2016. Objective aim this study was to evaluate implementation Netherlands. Methods Between 2011 2018, all who underwent surgery cancer were included from Upper GI Cancer Audit. evaluated before...
Abstract Background Anastomotic leakage is the most important surgical complication following esophagectomy. A major cause of ischemia gastric tube that used for reconstruction gastrointestinal tract. Generalized cardiovascular disease, expressed by calcifications aorta and celiac axis stenosis on a pre-operative CT scan, associated with an increased risk anastomotic leakage. Laparoscopic ischemic conditioning (ISCON) aims to redistribute blood flow increase perfusion at site occluding left...
Purpose: To explore whether a higher neoadjuvant radiation dose increases the probability of pathological complete response (pCR) or major (pMR) in oesophageal cancer patients.Material and methods: Between 2000 2017, 1048 patients from four institutions were stratified according to prescribed doses 36.0 Gy (13.3%), 40.0 (7.4%), 41.4 (20.1%), 45.0 (25.5%) 50.4 (33.7%) 1.8–2.0 fractions. Endpoints pCR (tumour regression grade (TRG) 1) pMR (TRG 1 + 2). Multivariable binary 2 vs. TRG > 2)...
To noninvasively quantify variation in intra-fraction motion of esophageal tumors over the course neoadjuvant chemoradiotherapy (nCRT) using 2D cine-magnetic resonance imaging (MRI) series. Patients treated with nCRT for cancer underwent six MRI scans. Scans were acquired prior to start nCRT, followed by weekly scans during nCRT. Cine-MRI series coronal and sagittal plane (≈1.6 Hz). be able a longer time period, second cine-MRI was performed after 10 min. Tumor assessed cranio-caudal (CC),...
The perceived burden of diagnostic tests by patients during the assessment esophageal cancer warrants attention with current increase in repeated imaging for purposes disease monitoring and after treatment. purpose this prospective study was to evaluate experienced associated MRI positron emission tomography integrated CT (PET/CT) examinations neoadjuvant treatment from perspective patient.In 27 receiving chemoradiotherapy (nCRT) PET/CT were performed before nCRT, nCRT surgery. evaluated a...
PurposeThis study aimed to assess the smallest clinical target volume (CTV) planned (PTV) margins for esophageal cancer radiotherapy using daily online registration bony anatomy that yield full dosimetric coverage over course of treatment.Methods29 patients underwent six T2-weighted MRI scans at weekly intervals. An bone-match image-guided treatment five fractions was simulated each patient. Multiple conformal plans with increasing around CTV were created Then, dose warped obtain an...