A5039108786- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Esophageal Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Sulfur Compounds in Biology
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Phytoestrogen effects and research
- Luminescence Properties of Advanced Materials
- Sesame and Sesamin Research
- Neuropeptides and Animal Physiology
Radboud University Medical Center
2019-2023
Radboud University Nijmegen
2018-2023
Maastricht University
2017-2021
Brigham and Women's Hospital
2021
Alfred University
2021
Jeroen Bosch Ziekenhuis
2019
University Medical Center
2019
Purpose: Current treatment options for muscle-invasive bladder cancer (MIBC) are associated with substantial morbidity. Local release of doxorubicin (DOX) from phosphatidyldiglycerol-based thermosensitive liposomes (DPPG 2 -TSL-DOX) potentiated by hyperthermia (HT) in the wall may result sparing without toxicity systemic chemotherapy. We investigated whether this approach, compared to conventional DOX application, increases concentrations while limiting essential organs. Materials and...
Neoadjuvant chemotherapy and radical cystectomy (RC) are underutilized standards of care for the treatment muscle-invasive bladder cancer (MIBC) due to high patient burden from systemic toxicities postoperative complications, respectively. TAR-200 is a novel intravesical drug delivery system developed release gemcitabine into urine continuously, resulting in distribution stromal layers bladder. The primary aim TAR-200-101 study was evaluate safety patients with MIBC prior RC...
Background: The recurrence rate of non-muscle invasive bladder cancer (NMIBC) is high, despite intravesical treatments. Importantly, patients are frequently unfit or unwilling to undergo a recommended radical cystectomy when standard treatments fail, due the substantial risk morbidity and mortality. For these patients, radiofrequency-induced hyperthermia combined with chemotherapy (RF-CHT) has shown promising results. We aim determine treatment outcomes assess effect (ablative) dose....
Abstract Background Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral therapies that delay recurrence or progression. We recently demonstrated in mice, metformin accumulates unchanged urine. Urothelial cells exposed concentrations ~ 240-fold higher than serum. This was treatment mouse models. Methods describe protocol a multi-centre,...
Abnormal ion channel expression distinguishes several types of carcinoma. Here, we explore the relationship between voltage-gated sodium channels (VGSC) and epithelial ovarian cancer (EOC). We find that EOC cell lines express most VGSC, but at lower levels than fallopian tube secretory cells (the origin for EOC) or control fibroblasts. Among patient tumor samples, SCN8A was associated with improved overall survival (OS) (median 111 vs. 52 months; HR 2.04 95% CI: 1.21-3.44; p = 0.007), while...
Purpose Recommended treatments for muscle-invasive bladder cancer (MIBC) come with considerable morbidity. Hyperthermia (HT) triggered drug release from phosphatidylglycerol-based thermosensitive liposomes (DPPG2-TSL) might prevent surgical removal and toxicity systemic chemotherapy. We aimed to assess the efficacy of DPPG2-TSL HT in a syngeneic orthotopic rat urothelial carcinoma model.Methods A total 191 female Fischer F344 rats were used. Bladder tumors initiated by inoculation AY-27...
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You have accessJournal of UrologyBladder Cancer: Non-invasive III (PD63)1 Sep 2021PD63-02 THE THERMAL DOSE DURING RADIOFREQUENCY-INDUCED HYPERTHERMIA COMBINED WITH INTRAVESICAL CHEMOTHERAPY APPEARS TO HAVE NO SIGNIFICANT EFFECT ON NON-MUSCLE INVASIVE BLADDER CANCER OUTCOME Iris Brummelhuis, Johannes Crezee, and Alfred Witjes BrummelhuisIris Brummelhuis More articles by this author , CrezeeJohannes Crezee WitjesAlfred View All Author...
You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology I (PD37)1 Sep 2021PD37-08 PHOSPHATIDYLDIGLYCEROL-BASED THERMOSENSITIVE LIPOSOMES SHOW SUPERIOR THERAPEUTIC EFFICACY AGAINST MUSCLE-INVASIVE BLADDER CANCER IN VIVO Iris Brummelhuis, Michiel Simons, Lars Lindner, Simone Kort, Sytse de Jong, Martin Hossann, Alfred Witjes, and Egbert Oosterwijk BrummelhuisIris Brummelhuis More articles by this author , SimonsMichiel Simons LindnerLars Lindner KortSimone Kort...