A5019156794- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Inflammatory Myopathies and Dermatomyositis
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Soft tissue tumor case studies
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Chemotherapy-related skin toxicity
- Colorectal and Anal Carcinomas
- Cutaneous lymphoproliferative disorders research
- Polyomavirus and related diseases
- DNA Repair Mechanisms
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
Universidade de São Paulo
2012-2025
Universidade de Ribeirão Preto
2025
Clinics Hospital of Ribeirão Preto
2015-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2022
Sociedade Brasileira de Oncologia Clínica
2022
PURPOSE The global, phase 3, open-label, randomized TROPION-Breast01 study assessed the trophoblast cell surface antigen 2–directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) versus investigator's choice of chemotherapy (ICC) in hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–) breast cancer. METHODS Adult patients with inoperable/metastatic HR+/HER2‒ cancer, who had disease progression on endocrine therapy, for whom therapy was...
This study compared mirtazapine with megestrol in the management of cancer-related anorexia-cachexia syndrome patients advanced cancer. A randomized, double-blind, controlled clinical trial involving cancer and was performed. Participants received 30 mg/day or 320 for eight weeks. The primary endpoint effect on weight gain secondary endpoints were its appetite, muscle strength, physical performance, body composition, adverse events, medication adherence. Linear regression model mixed effects...
448 Background: T-DXd is a HER2-directed antibody-drug conjugate; 6.4 mg/kg monotherapy approved for patients with metastatic HER2+ GC/GEJA who have received prior trastuzumab-based regimen. Preliminary results from DG-03 Part 2 showed feasibility and promising antitumor activity 1L (arm D) or 5.4 F) FP pembrolizumab in esophageal adenocarcinoma/GC/GEJA. was associated higher than expected toxicity; alternatively, early safety data triplet combination manageable profile. We report updated...
INTRODUCTION: Multiple stages of carcinogenesis in colon cancer encompass subpopulations stem cells (CSC), responsible for tumor cell transformation, growth and proliferation. CD44 CD166 proteins are CSC markers associated with signaling, adhesion, migration, metastasis lymph ocytic response. The expression may be modulated by some factors, such as the KRAS gene mutation. OBJECTIVE: Correlate metastatic adenocarcinoma mutation status (wild-type/mutated) clinical pathological features...
Here, we describe the case of a patient diagnosed with locally advanced breast cancer 8 years ago. Her treatment course was neoadjuvant chemotherapy, followed by mastectomy and then adjuvant radiotherapy trastuzumab (TTZ). During use targeted therapy, an incidental pregnancy diagnosed. Four later, she developed bone cerebral metastases, since then, has received courses TTZ, capecitabine, lapatinib, intermittent control disease. 7-year-old son presents normal physical long-term neurological...
KRAS gene mutations play an important role in the carcinogenesis of colorectal tumors. However, studies that have assessed association between mutation status and disease characteristics report conflicting results. To assess (mutated or wild-type) its with clinical, epidemiological, histopathological features metastatic adenocarcinoma as well clinical outcomes.Cross-sectional descriptive study which data were collected from medical records 65 patients diagnosed at Clinical Oncology Service...
Abstract Polygenic risk scores (PRS) quantify the genetic of diseases based on alleles in genomic loci identified genome-wide association studies (GWAS). As individuals European ancestry are overrepresented GWAS, PRS performance may vary different ancestries. Brazil is largest and most populated country Latin America, with around 43% admixed individuals, data breast cancer for this population lacking. We aimed to evaluate a 313 SNPs generated Europeans Brazilian population. In case-control...
Collecting duct carcinoma (CDC) is a rare disease associated with high mortality rate. The present study describes the case of recipient kidney transplant metastatic allograft CDC whose treatment was successful. patient underwent nephrectomy, and chemotherapy gemcitabine cisplatin, while undergoing haemodialysis remained in remission after 6 years follow-up. There lack information about clinical management CDC; however, combination cisplatin remains as first-line therapy. challenge this...
Cancer-related fatigue is characterized by feelings of extreme tiredness, which do not improve with rest and negatively affects the physical psychosocial function patients, significantly reducing their quality life.The prevalence in cancer patients undergoing chemotherapy can be as high 90%.Colorectal one neoplasms highest incidence cancer-related fatigue, especially among individuals older than 65 years old.To perform a comparative assessment ofcancer-related colorectal during first four...
Bloom's syndrome is a rare disease that related to an increased risk of developing malignant neoplasm.The patient reported was followed up with several hospital staff when she diagnosed gastric cancer, but unfortunately, had already peritoneal implants in moment the surgery approach.It has been literature patients this present greater toxicity chemotherapeutic treatment, however due rarity disease, it not known exactly how adjustment these drugs should be performed and which better protocol...
We report a case of paraneoplastic dermatomyositis in patient with diagnosis neuroendocrine tumor an unknown primary site.A 49-year-old woman, hypertensive, was admitted to our hospital due mass detected by abdominal computed tomography, contact the liver and gallbladder, having compressive effect on inferior vena cava, measuring 10.4 x 7.3 7.8 cm.Pathological examination showed signet-ring cell neoplasm ki-67 proliferation index 60%, microscopic immunohistochemical findings indicated...
Obesity is a growing clinical condition around the world, considered risk factor for numerous diseases such as hypertension, myocardial infarction, diabetes, and cancer.Among neoplasms related to overweight, breast cancer stands out.Therefore, objective of this review elucidate impact obesity on most prevalent among women, either direct its onset or determinant survival.
e15190 Background: Gastric cancer is a common malignant disease with high mortality rate. Neoadjuvant treatment efficient, but not the first option for in all countries. Studies of neadjuvant chemotherapy gastric South American countries are lacking. The aim this retrospective analysis was to investigate use ECX (epirubicin, cisplatin, and capecitabine) regimen neoadjuvant therapy Brazilian population. Methods: 25 patients (median age, 61; range 36-78 years; 14 pts >60 years) locally...
650 Background: Neuroendocrine tumors are rare malignant neoplasms derived from endocrine cells and known for their heterogeneous behavior histopathological characteristics; however, largely associated with a favorable clinical outcome. Somatostatin analogues (SSA) were initially used to control the symptoms of secretory neuroendocrine tumors, later, they considered effective as first-line systemic treatment in unresectable or metastatic gastroenteropancreatic tract (NET-GEP). Randomized...
Os tumores neuroendócrinos primários de mama (TNPMs) são incomuns e não há consenso quanto a tratamento prognóstico. No presente trabalho, foram revisados os diagnósticos 1.184 pacientes com câncer atendidos no Hospital das Clínicas da Faculdade Medicina Ribeirão Preto Universidade São Paulo (HCFMRP/USP), identificando três casos que preenchiam critérios TNPM, segundo classificação estabelecida pela Organização Mundial Saúde (OMS) em 2003. Foram avaliados achados clinicopatológicos...
Introduction: Head and neck cancer (HNC) is a heterogeneous group of neoplasms that can have poor prognosis when diagnosed in advanced stages. The optimized treatment for locally unresectable lesions mainly based on radiotherapy associated with chemotherapy (cisplatin 100mg/m²), however, at the expense high toxicity index. Objective: Evaluate whether chemoradiotherapy (CRT) â goldstandard head effective study population. Methods: This retrospective aimed determining efficacy definitive...