A5048143305- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Radiation Therapy and Dosimetry
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Tryptophan and brain disorders
- Advanced Radiotherapy Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Ultrasound and Hyperthermia Applications
- Pharmaceutical Practices and Patient Outcomes
- Cell death mechanisms and regulation
- Antibiotic Use and Resistance
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
Kothiwal Dental College and Research Centre
2024-2025
Dr. D.Y. Patil Vidyapeeth, Pune
2025
Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
2025
Kowloon Hospital
2025
Maharashtra Institute of Medical Science and Research
2025
Government Medical College
2007-2024
Georgetown University
2018-2023
Georgetown University Medical Center
2018-2023
ACPM Dental College and Hospital
2023
Government Medical College and Hospital
2022-2023
Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing progression. Recruitment of these is regulated by integrins, a family adhesion receptors that includes integrin CD11b. Here we report that, unexpectedly, CD11b does not regulate myeloid cell recruitment tumors but instead controls polarization growth. activation promotes pro-inflammatory macrophage stimulating expression microRNA Let7a. In contrast, inhibition prevents...
Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects. Here, we studied potential therapeutic and effects of one combination: Ab OX40/vaccine. We different treatment sequencing this combination. report simultaneous addition anti-PD-1 negated OX40 Ab. Antigen-specific CD8+ T-cell infiltration into tumor was...
Radiation is a potent immune-modulator that elicits cell death upon tumor, stromal and angiogenic compartments of tumor microenvironment. Here, we test novel approach high-dose radiation delivery using three dimensional volume based lattice therapy (LRT) to understand the impact different irradiation in eliciting both local metastatic/distant control through modulation immune micro-environment. To study such effects LRT, tumors were implanted hind legs C57BL/6 mice Lewis lung carcinoma 1...
Abstract In the present study, ionizing radiation (IR)–induced bystander effects were investigated in two lung cancer cell lines. A549 cells found to be more resistant radiation-conditioned medium (RCM) obtained from when compared with H460 exposed RCM procured cells. Significant release of tumor necrosis factor-α (TNF-α) was observed after IR/RCM exposure, and survival reversed neutralizing antibody against TNF-α. cells, significant TNF-related apoptosis-inducing ligand (TRAIL), but not...
•Improvement of therapeutic ratio by novel unconventional radiotherapy approaches.•Immunomodulation using high-dose spatially fractionated radiotherapy.•Boosting radiation anti-tumor effects adding an immune-mediated cell killing.
Purpose: Two-dimensional (2D) high-dose GRID radiotherapy has shown effective tumor control in the clinical setting, and radiobiological data suggest potent bystander/abscopal effects with this technique. We present a new technical concept using modern radiation therapy instrumentation to advance traditional treatment three-dimensional (3D) LATTICE (LRT). Materials Methods: An array of focused volumes, essence lattice doses 3D, can be generated through techniques resulting highly...
In this study, the role of hyper-radiation sensitivity (HRS) in potentiating effects cisplatin by low-dose fractionated radiation (LDFRT) was evaluated four human non-small cell lung cancer lines. Presence HRS and enhancement ratio (CER) LDFRT/2 Gy assessed using colony-forming apoptotic assays. Cell-cycle disturbances were studied flow cytometry. Expression genes involved apoptosis real-time reverse transcriptase PCR arrays. H-157 cells showed a distinct region, followed UKY-29 A549 cells,...
To compare the rejection rates of non-small cell lung cancer (NSCLC) samples obtained by differing sampling methods for testing Sanger sequencing epidermal growth factor receptor (EGFR) mutations. assess association between unsatisfactory outcomes and quantity DNA extracted from cytological versus histological samples.Six hundred seventy NSCLC referred to our centre 2008 2010 were reviewed as a consequence sample rejection, presence EGFR mutations, methods, genotyping rate.Eighty rejected in...
Abstract The immunosuppressive tumor microenvironment (TME) does not allow generation and expansion of antitumor effector cells. One the potent factors present in TME is indoleamine-pyrrole 2,3-dioxygenase (IDO) enzyme, produced mainly by cancer cells suppressive immune myeloid origin. In fact, IDO+ myeloid-derived suppressor (MDSC) dendritic (DC) tend to be more than their IDO− counterparts. Hence, therapeutic approaches that would target TME, while sparing antigen-presenting functions...
Introduction: Dental anxiety is a prevalent issue among patients undergoing minor oral surgical procedures such as extractions, biopsies, and implant placement. This study aimed to evaluate the impact of alprazolam premedicative anxiolytic agent on vital parameters, including pulse rate (PR), systolic diastolic blood pressure (SBP DBP, respectively), respiratory (RR), oxygen saturation (SpO2), in surgeries. Materials methods: A quasi-experimental was conducted aged 18-45 years who required...
Abstract Oncogenic ras is known to inhibit cell death and growth inhibitory genes activate prosurvival genes. Proapoptotic gene PAR‐4, has been found be downregulated by oncogenic ras. Since pancreatic tumors harbor a high incidence of K‐ras point mutations, we hypothesized that might influence the function expression PAR‐4. PAR‐4 levels were analyzed in 4 established tumor lines, 10 normal tissues, 44 frozen tissues 25 paraffin‐embedded adenocarcinoma samples Real Time RT‐PCR, Western blot...
Patients admitted to cardiology department are mostly on polypharmacy. So drug-drug interactions and adverse effects of drugs quite common. Yet, there is a paucity data regarding drug reaction (ADR) monitoring in India. The present study an effort fill up these lacunae.A prospective, observational registering 966 indoor patients according predetermined inclusion exclusion criteria was conducted for one year. ADR profile noted by spontaneous reporting intensive monitoring. Naranjo probability...