A5015839480- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Tryptophan and brain disorders
- Bacteriophages and microbial interactions
- Oral and Maxillofacial Pathology
- Antibiotic Resistance in Bacteria
- Cancer, Stress, Anesthesia, and Immune Response
- Bacterial biofilms and quorum sensing
- Ferroptosis and cancer prognosis
- Escherichia coli research studies
- Dietary Effects on Health
- Histone Deacetylase Inhibitors Research
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Cancer Risks and Factors
Hormel (United States)
2022-2025
University of Minnesota
2022-2025
Shree Krishna Hospital
2023
Georgetown University
2020-2023
Georgetown University Medical Center
2020-2023
University of Minnesota Medical Center
2023
Augusta University Health
2017-2022
Max Healthcare
2018-2022
Chonnam National University
2013-2022
Central University of Rajasthan
2021
Vibrio vulnificus is a halophilic estuarine bacterium that causes fatal septicemia and necrotizing wound infections in humans. Virulent V. isolates produce catechol siderophore called vulnibactin, made up of one residue 2, 3-dihydroxybenzoic acid (2, 3-DHBA) two residues salicylic (SA). Vulnibactin biosynthetic genes (VV2_0828 to VV2_0844) are clustered at locus chromosome expression which significantly up-regulated vivo. In the present study, we decipher network focusing specifically on...
Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects. Here, we studied potential therapeutic and effects of one combination: Ab OX40/vaccine. We different treatment sequencing this combination. report simultaneous addition anti-PD-1 negated OX40 Ab. Antigen-specific CD8+ T-cell infiltration into tumor was...
To modulate T-cell function for cancer therapy, one challenge is to selectively attenuate regulatory but not conventional CD4+ subsets [regulatory T cell (Treg) and (Tconv)]. In this study, we show how a functional dichotomy in Class IA PI3K isoforms these two of cells can be exploited target Treg while leaving Tconv intact. Studies employing isoform-specific inhibitors PI3Kδ-deficient mouse strain revealed that PI3Kα PI3Kβ were functionally redundant with PI3Kδ Tconv. Conversely, was...
The in vitro efficacy of lytic bacteriophage as a therapeutic agent against Klebsiella pneumoniae biofilm, alone or combination with ciprofloxacin, was studied. pathogenic potential the resistant variants formed during treatment evaluated. A ciprofloxacin used for K. B5055 biofilm. and frequency variant formation were estimated after respective treatments. characterized their virulence potential. Bacteriophage able to eradicate biofilm effectively no significant difference observed its...
Bacteria have evolved multiple mechanisms, such as biofilm formation, to thwart antibiotic action. Yet antibiotics remain the drug of choice against clinical infections. It has been documented that young Klebsiella pneumoniae could be eradicated significantly by ciprofloxacin treatment alone. Since age is a decisive factor in determining outcome treatment, present study K. pneumoniae, grown for extended periods was treated with and/or depolymerase producing lytic bacteriophage (KPO1K2). The...
The aims of this study were to evaluate the efficacy preoperative denosumab in achieving prospectively decided intention therapy operable giant cell tumour bone (GCTB) patients, and document local recurrence-free survival (LRFS).A total 44 patients received denosumab: 22 facilitate curettage, 16 resection, six with intent converting resection curettage. There 26 male 18 female patients. mean age was 27 years (13 47).The number treatments five (2 7) per patient. In 42 (95%), helped achieve...
Abstract The immunosuppressive tumor microenvironment (TME) does not allow generation and expansion of antitumor effector cells. One the potent factors present in TME is indoleamine-pyrrole 2,3-dioxygenase (IDO) enzyme, produced mainly by cancer cells suppressive immune myeloid origin. In fact, IDO+ myeloid-derived suppressor (MDSC) dendritic (DC) tend to be more than their IDO− counterparts. Hence, therapeutic approaches that would target TME, while sparing antigen-presenting functions...
Cervical cancer is a high-incidence female most commonly caused by human papilloma virus (HPV) infection of the genital mucosa. Immunotherapy targeting HPV-derived tumor antigens (TAs) has been widely studied in animal models and patients. Because tract portal for entry HPV highly compartmentalized system, development topical vaginal immunotherapy an orthotopic model would provide ideal therapeutic. Thus, we examined whether flagellin, potent mucosal immunomodulator, could be used as...
// Vivek Verma 1, 9, 10 , Young Kim 2 Min-Cheol Lee Jae-Tae 3 Sunghoon Cho 4 In-Kyu Park 5 Jung Joon Min 6 Je 7 Shee Eun 8 Haeng Rhee 9 1 Clinical Vaccine R&D Center, Chonnam National University Medical School, Gwangju, South Korea Department of Pathology, Nuclear Medicine, Kyungpook School Daegu, Mechanical Systems Engineering, University, Biomedical Science, Research Center for Cancer Immunotherapy, Hwasun Hospital, Hwasun, Pharmacology and Dental Therapeutics, Dentistry, Microbiology,...
Therapeutic cancer vaccines (TCVs) should induce robust tumor-specific T cell responses. To achieve this, TCVs incorporate epitopes and strong adjuvants. Here, we report an all-in-one adjuvanted vaccine platform that targets the intracellular compartment of dentritic cells subsequently induces effective cytotoxic We screened a novel peptide (DCpep6) specifically binds transmits into CD11c+ through in vivo phage biopanning. then engineered protein-based TCV (DEF) consisting DCpep6 (D),...
Anticancer immunotherapies, such as immune checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T cells, have improved outcomes for patients with a variety of malignancies. However, most either do not initially respond or exhibit durable responses due to primary adaptive/acquired resistance mechanisms the tumor microenvironment. These suppressive programs are myriad, different between ostensibly same cancer type, can harness multiple cell types reinforce their...
Purpose: Human papillomavirus (HPV) is a significant cause of cervical cancer-related deaths worldwide.Because HPV sexually transmitted mucosal pathogen, enhancement antigen-specific immune response likely serves good strategy for vaccination.However, vaccines generally do not induce strong enough responses.Previously we proved that bacterial flagellin, Vibrio vulnificus FlaB, responses by stimulating the Toll-like receptor 5. In this study, tested whether FlaB could serve as an effective...
Noroviruses (NoVs) are a major cause of childhood gastroenteritis and foodborne diseases worldwide. Lack appropriate animal models or cell-based culture systems makes the development evaluation NoV-specific vaccines daunting task. VP1 is capsid protein NoVs that acts as binding motif to human histo-blood group antigens (HBGAs) through its protruding 2 (P2) domain can serve protective antigen candidate for vaccine development. Recombinantly produced NoV specific P (Pd) was inoculated into...
Despite medical advancements, Escherichia coli-associated infections remain a major public health concern and although an abundant information about E. coli its antibiotic resistance mechanisms is available, no effective tool exists that integrates gene genomic data in context to drug resistance, thus raising need develop repository facilitates integration assimilation of factors governing coli.User-friendly Comprehensive Antibiotic Repository (u-CARE) manually curated catalogue 52...
Norovirus causes acute and debilitating gastroenteritis, characterized by vomiting diarrhea. We recently reported a recombinant GII. 4 P domain particle (Pd) vaccine adjuvanted with flagellin, Vibrio vulnificus FlaB, effectively promoting both humoral cell-mediated immune responses. In the previous study, we found that sublingual (SL) immunization induced higher fecal secretory IgA (SIgA) responses while intranasal (IN) route provided amplitude of cellular in systemic compartment....
Over 50% of women at a childbearing age in the United States are overweight or obese, and this can adversely affect their offspring. We studied if maternal obesity-inducing high fat diet (HFD) not only increases offspring’s mammary cancer risk but also impairs response to antiestrogen tamoxifen. Female rat offspring HFD control diet-fed dams, which estrogen receptor-positive (ER+) tumors were induced with carcinogen 7,12-dimethylbenz[a]anthracene (DMBA), exhibited similar initial responses...
Journal Article Hepatitis E virus‐based evaluation of a virion concentration method and detection enteric viruses in environmental samples by multiplex nested RT‐PCR Get access V. Verma, Verma National Institute Virology, Pashan, Pune, India Search for other works this author on: Oxford Academic Google Scholar V.A. Arankalle Vidya A. Arankalle, Scientist F, Head, Division, 130/1, Sus Road, 41021. E‐mail: varankalle@yahoo.com Applied Microbiology, Volume 108, Issue 5, 1 May 2010, Pages...