A5045546332- Chromosomal and Genetic Variations
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- Cancer Treatment and Pharmacology
- Cervical Cancer and HPV Research
- Genomics and Phylogenetic Studies
- Viral-associated cancers and disorders
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Xenotransplantation and immune response
- Immune cells in cancer
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pleistocene-Era Hominins and Archaeology
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Migration, Identity, and Health
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Migration, Health and Trauma
- Risk Perception and Management
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
Fondazione Poliambulanza Istituto Ospedaliero
2019-2022
Albert Einstein College of Medicine
2008-2014
Yeshiva University
2012
University of Brescia
2005-2009
Human endogenous retroviruses (HERVs) are transcribed in many cancers including prostate cancer. retrovirus K (HERV-K) of the HML2 subtype is most recently integrated and intact human genome, with viral genomes encoding full- or partial-length proteins. To assess transcripts HERV-K cancer cell lines identify specific elements genome that transcribed, reverse transcriptase-PCR (RT-PCR) cDNA sequencing were undertaken. Strand-specific RT-PCR, plasmid subcloning, detected presence HERV-K(HML2)...
Human endogenous retrovirus K (HERV-K) is the most intact in human genome. There are multiple full-length or near HERV-K proviruses it. To analyze which give rise to viral transcripts cancer cell lines and test whether ionizing radiation can alter levels of transcripts, RT-PCR studies were undertaken using lines. Primers from several positions genome used included pairs designed cross splice junctions RNAs. In absence radiation, detected prostate, cervical, head neck, breast cancers,...
Abstract Cervical carcinogenesis, the second leading cause of cancer death in women worldwide, is caused by multiple types human papillomaviruses (HPVs). To investigate a possible role for HPV cervical carcinoma that was HPV‐negative PCR testing, we performed DNA hybridization capture plus massively parallel sequencing. This detected subgenomic, URR‐E6‐E7‐E1 segment HPV70 DNA, type not generally associated with cancer, inserted an intron B‐cell lymphoma/leukemia 11B ( BCL11B ) gene genome....
5154 Background: Treatment of choice for patients (pts) with platinum-resistant ovarian cancer (OC) is to be defined. LD active in relapsed OC a response rate 25%. G has shown activity as second line chemotherapy. Our purpose was evaluate the and safety combination chemotherapy pts, previously treated at least one platinum containing regimens. Methods: Between Apr 2002 November 2004, 20 pts recurrence histologically proven epithelial entered study were 700 mg/m2 (30 min i.v.) on day 1,8 30...
TAM is a non-steroidal anti-estrogen used as adjuvant hormonal therapy in women with breast cancer. also has estrogenic activity on endometrium leading to increased risk of endometrial changes. These patients are usually screened transvaginal ultrasound. This study evaluates sonohysterography (SIS) detecting lesions undergoing TAM-therapy after abnormal ultrasound screening. Retrospective analysis 82 (mean age 61) undergone SIS from January 2000 December 2006. Postmenopausal were 82%. We...
Abstract Ionizing Radiation (IR) has been reported to increase the transcriptional activity of many viruses, including retroviruses. We hypothesized that IR could reactivate subsets Human Endogenous Retroviruses (HERVs), which are retroviruses integrated into human genome, remnants ancient retroviral infections, and HERV-derived peptides, final product HERVs transcription, will diversity antigen repertoire presented by irradiated cancer cells, thereby inducing anti-tumor immune responses....
16565 Background: A synthetic benzyl styryl sulfone (ON019010.Na) has been shown to have anti-tumor activity, alone and in combination with other chemotherapeutic agents as a Chk2 inhibitor anti-mitotic agent that induces selective G2/M arrest followed by apoptosis several cancer cell lines. It is now undergoing phase 1–2 clinical trials. Cisplatin the preferred primary chemotherapy for cervical malignancies. Studies were initiated test if ON01910.Na may be used on checkpoint-compromised...
Abstract Cervical carcinogenesis, the second leading cause of cancer death in women worldwide, is caused by multiple types human papillomaviruses (HPVs). To investigate a possible role for HPV cervical carcinoma that was HPV-negative PCR testing, we performed DNA hybridization capture plus massively parallel sequencing. This detected subgenomic, URR- E6-E7-E1 segment HPV70 DNA, type not generally associated with cancer, inserted an intron B-cell lymphoma/leukemia 11B ( BCL11B ) gene genome....