A5103200773- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Cancer survivorship and care
- Gynecological conditions and treatments
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Palliative Care and End-of-Life Issues
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Diversity and Career in Medicine
- Cancer Risks and Factors
- Intraperitoneal and Appendiceal Malignancies
- Reproductive tract infections research
- Microtubule and mitosis dynamics
- Childhood Cancer Survivors' Quality of Life
Northwell Health
2018-2025
Long Island Jewish Medical Center
2020-2024
Feinstein Institute for Medical Research
2021-2024
Cold Spring Harbor Laboratory
2023-2024
Jewish Hospital
2024
North Shore Diabetes and Endocrine Associates
2024
Albert Einstein College of Medicine
2011-2023
Hofstra University
2017-2023
Women's Health Research Institute
1995-2023
Gynecologic Oncology Group
1994-2023
PURPOSE Based on the results of our phase I study that demonstrated antitumor activity taxol in a previously treated patient with ovarian cancer, II was conducted to evaluate efficacy patients metastatic cancer and further toxicity this group patients. PATIENTS AND METHODS Thirty-four received (180 250 mg/m2) as 24-hour continuous infusion. A premedication regimen used reduce likelihood an acute hypersensitivity reaction. RESULTS Six 30 assessable complete responses (one patient) or partial...
Abstract A case control design has been used to investigate risk factors associated with the development of cervical squamous intraepithelial lesions (SIL) in a population urban women which non‐affluent minority groups were heavily represented. Eighty‐five histologically confirmed SIL compared group 70 cytologically normal women. HPV infection was determined using both Southern blot hybridization and polymerase chain reaction (PCR) amplification specific for types 16, 18, 33. When detect...
In Brief OBJECTIVE: Obesity is an established risk factor for development of endometrial cancer. We hypothesized that obesity might also be associated with earlier age at cancer diagnosis, because mechanisms drive the obesity–endometrial association accelerate tumorigenesis. METHODS: A retrospective chart review was conducted all cases diagnosed from 1999 to 2009 a large medical center in New York City. The body mass index (BMI) comorbidities, stage, grade, and radiation treatment examined...
Abstract Background To date there have been no comprehensive, comparative assessments of the environmental impact surgical modalities. Our study seeks to quantify and compare total greenhouse gas emissions, or 'carbon footprint', attributable three Methods A review 150 staging procedures, employing laparotomy (LAP), conventional laparoscopy (LSC) robotically‐assisted (RA‐LSC), was performed. The solid waste generated (kg) energy consumed (kWh) during each case were quantified converted into...
This study was undertaken to examine the role of insulin-like growth factor (IGF) signaling pathway in response ovarian cancer cells Taxol and evaluate significance this human epithelial tumors.The effect treatment on AKT activation A2780 carcinoma evaluated using antibodies specific for phospho-AKT. To drug-resistant phenotype, we developed a Taxol-resistant cell line, HEY-T30, derived from HEY cells. IGF2 expression measured by real-time PCR. A type 1 IGF receptor (IGF1R) inhibitor,...
Objective We assessed whether famotidine improved inflammation and symptomatic recovery in outpatients with mild to moderate COVID-19. Design Randomised, double-blind, placebo-controlled, fully remote, phase 2 clinical trial ( NCT04724720 ) enrolling unvaccinated adult confirmed COVID-19 between January 2021 April from two US centres. Patients self-administered 80 mg (n=28) or placebo (n=27) orally three times a day for 14 consecutive days. Endpoints were time (primary) rate of (secondary)...
Endometrial cancer is the most common gynecologic malignancy in United States and one of few malignancies that had an increasing incidence mortality rate over last 10 years. Current research models fail to recapitulate actual characteristics tumor are necessary for proper understanding treatment this heterogenous disease. Patient-derived organoids provide a durable versatile culture system can capture patient-specific such as mutational profile response therapy primary tumor. Here we...
Vaginal, perineal, and pelvic floor reconstruction is being performed with increasing frequency in conjunction radical surgery. Although the vertical rectus abdominis myocutaneous flap ideally suited to such procedures, little information exists regarding risks or complications associated it.A chart review of all patients who underwent this procedure at two institutions was performed, results were compared existing series. Surviving asked describe their satisfaction sexual function.Between...
To evaluate the safety and survival in women treated with adjuvant pelvic radiation "sandwiched" between six cycles of paclitaxel carboplatin chemotherapy completely resected UPSC.Surgically staged UPSC (FIGO stage 1-4) no visible residual disease were enrolled. Treatment involved (175 mg/m(2)) (AUC=6.0-7.5) every 21 days for 3 doses, followed by therapy (RT), an additional (AUC=5-6). Survival analysis, using Kaplan-Meier methods, was performed on patients who completed at least RT.A total...
Uterine carcinosarcoma (CS) is a rare uterine tumor with an extremely poor prognosis. In the adjuvant setting, efficacy has been shown radiotherapy (RT), systemic chemotherapy, or both. This first report describing and toxicity of ifosfamide plus cisplatin "sandwiched" RT in patients surgically staged completely resected carcinosarcoma.Women CS no gross residual disease were initially administered (1.2 g/m(2)/day×5 days) (20 mg/m(2)/day×5 every 3 weeks for cycles followed by pelvic external...
To evaluate the association of 3 hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) use and concordant polypharmacy with disease-specific survival from endometrial cancer.A retrospective cohort study was conducted 985 cancer cases treated January 1999 through December 2009 at a single institution. Disease-specific estimated by Kaplan-Meier analyses. Cox proportional hazards model used to factors associated survival. All statistical tests were two-sided performed using Stata.At...
Abstract Purpose: Uterine carcinosarcoma is a rare aggressive malignancy frequently presenting at advanced stage of disease with extrauterine metastases. Median survival less than 2 years due to high relapse rates after surgery and poor response chemotherapy or radiotherapy. The goal this study was identify novel therapeutic targets. Experimental Design: We applied RNA-seq analysis prospectively collected uterine tumor samples from patients undergoing primary surgical resection for...