A5012389167- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Fibroblast Growth Factor Research
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
University of California, San Diego
2018-2020
Comprehensive Cancer Center Vienna
2015-2018
Medical University of Vienna
2017
Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing progression. Recruitment of these is regulated by integrins, a family adhesion receptors that includes integrin CD11b. Here we report that, unexpectedly, CD11b does not regulate myeloid cell recruitment tumors but instead controls polarization growth. activation promotes pro-inflammatory macrophage stimulating expression microRNA Let7a. In contrast, inhibition prevents...
Inhibitors of the epidermal growth factor receptor (EGFR) are first-line therapy for patients with metastatic colorectal tumors without RAS mutations. However, EGFR inhibitors ineffective in these patients, and tumor level does not associate response to therapy. We screened human EGFR-positive myeloid cells investigated their association patient outcome. also performed studies mice evaluate how expression contributes development colitis-associated cancer Apc
The interferon‐inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex‐specific functions colitis and colitis‐associated colorectal cancer (CRC) using mice with specific deletion intestinal epithelial cells (STAT1 ∆IEC ). Male but not female were more resistant to DSS‐induced than sex‐matched flox/flox controls displayed reduced intraepithelial infiltration of CD8 + TCRαβ granzyme B T cells. Moreover, DSS treatment failed induce expression...
Myeloid cells lacking STAT3 promote antitumor responses of NK and T but it is unknown if this crosstalk affects development autochthonous tumors. We deleted in murine myeloid (STAT3Δm) examined the effect on colorectal cancers (CRCs). Formation Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed STAT3Δm mice. Gene expression profiling showed strong activation stroma CRCs. Moreover, host mice were better able to control growth transplanted MC38 tumor which are known be...
Abstract Tumor-associated macrophages (TAM) are highly expressed within the tumor microenvironment of a wide range cancers, where they exert protumor phenotype by promoting cell growth and suppressing antitumor immune function. Here, we show that TAM accumulation in human mouse tumors correlates with expression integrin αvβ3, known driver epithelial cancer progression drug resistance. A monoclonal antibody targeting αvβ3 (LM609) exploited coenrichment TAMs to not only eradicate aggressive...
<p>Enlarged images showing immunohistochemistry for integrin beta3 and macrophage markers multiple tumor types.</p>
<p>Figure shows tumor growth and integrin avb3 expression for HCC827 lung tumors with in vivo acquired resistance to erlotinib.</p>
<p>Figure shows tumor growth and integrin avb3 expression for HCC827 lung tumors with in vivo acquired resistance to erlotinib.</p>
<div>Abstract<p>Tumor-associated macrophages (TAM) are highly expressed within the tumor microenvironment of a wide range cancers, where they exert protumor phenotype by promoting cell growth and suppressing antitumor immune function. Here, we show that TAM accumulation in human mouse tumors correlates with expression integrin αvβ3, known driver epithelial cancer progression drug resistance. A monoclonal antibody targeting αvβ3 (LM609) exploited coenrichment TAMs to not only...
<p>Table of correlation coefficients for ITGB3 and immune cell types across multiple cancers, expression the TCGA pan-cancer dataset</p>
<p>Table of correlation coefficients for ITGB3 and immune cell types across multiple cancers, expression the TCGA pan-cancer dataset</p>
<div>Abstract<p>Tumor-associated macrophages (TAM) are highly expressed within the tumor microenvironment of a wide range cancers, where they exert protumor phenotype by promoting cell growth and suppressing antitumor immune function. Here, we show that TAM accumulation in human mouse tumors correlates with expression integrin αvβ3, known driver epithelial cancer progression drug resistance. A monoclonal antibody targeting αvβ3 (LM609) exploited coenrichment TAMs to not only...
<p>Enlarged images showing immunohistochemistry for integrin beta3 and macrophage markers multiple tumor types.</p>
<p>Supplementary data, including additional antibody-mediated killing assays and confirmation of integrin avb3 expression by flow cytometry.</p>
<p>Gene expression marker sets, including immune cell markers used for Figure 1</p>
<p>Supplementary methods, including CRISPR sequences and antibodies</p>
<p>Supplementary data, including additional antibody-mediated killing assays and confirmation of integrin avb3 expression by flow cytometry.</p>
<p>Gene expression marker sets, including immune cell markers used for Figure 1</p>
<p>Supplementary methods, including CRISPR sequences and antibodies</p>
Abstract Macrophages play a key role in promoting tumor growth and resistance to therapy. Here we show that tissue-resident as well bone marrow-derived macrophages critical roles growth. Tissue-resident were recently shown originate the yolk sac or fetal liver during embryogenesis; these cells self-maintain post-natal tissues independent of hematopoietic stem cells. rapidly accumulate tumors where they are CD11b+Gr1-F4/80hiCX3CR1hiCCR2-Ki67+ independently trafficking receptors. In contrast,...
We previously reported that macrophage PI3-kinase γ (PI3Kγ) controls a critical switch between immune stimulation and suppression during inflammation cancer. PI3Kγ inhibition repolarizes tumor-associated macrophages, leading to downregulation of suppressive factors such as Arginase IL10 upregulation IL12 other pro-inflammatory cytokines. This results in recruitment activation intratumoral CD8+ T cells, well induction immunological memory (Kaneda et al 2016). In the present study, we...
Abstract We previously reported that macrophage PI3-kinase γ (PI3Kγ) controls a critical switch between immune stimulation and suppression during inflammation cancer. PI3Kγ inhibition repolarizes tumor-associated macrophages, leading to downregulation of suppressive factors such as Arginase IL10 upregulation IL12 other pro-inflammatory cytokines. This results in recruitment activation intratumoral CD8+ T cells, well induction immunological memory (Kaneda et al 2016). In the present study, we...
Abstract Macrophages play a key role in promoting tumor growth and resistance to therapy. Here we show that Tissue Resident (TRM) as well Bone Marrow-Derived (BMDM) critical but unique roles growth. TRM were recently shown originate the yolk sac or fetal liver during embryogenesis; these cells self-maintain post-natal tissues independent of hematopoietic stem cells. We found BMDM are CD11b+Gr1+F4/80loCX3CR1loCCR2+and recruited tumors CCR2-dependent manner. In contrast,...