A5075480785- Ocular Oncology and Treatments
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Cutaneous Melanoma Detection and Management
- Corneal Surgery and Treatments
- Neuroscience and Neural Engineering
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Infections and Treatments
- Immunotherapy and Immune Responses
- Photoreceptor and optogenetics research
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Nitric Oxide and Endothelin Effects
- Glioma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Multiple Myeloma Research and Treatments
- Optical Imaging and Spectroscopy Techniques
- Drug-Induced Ocular Toxicity
- Advanced Fluorescence Microscopy Techniques
- Ocular and Laser Science Research
Rigshospitalet
2016-2025
University of Copenhagen
2013-2025
Copenhagen University Hospital
2016-2025
Glostrup Hospital
2014-2024
Agostino Gemelli University Polyclinic
2018
Università Cattolica del Sacro Cuore
2018
Gentofte Hospital
2017
Herlev Hospital
2006
University of Iceland
2003
National University Hospital
1999
// Peter Johansson 1 , Lauren G. Aoude Karin Wadt 2 William J. Glasson 3 Sunil K. Warrier Alex W. Hewitt 4, 5 Jens Folke Kiilgaard 6 Steffen Heegaard 6, 7 Tim Isaacs Maria Franchina Christian Ingvar 8 Tersia Vermeulen 9 Kevin Whitehead 10 Christopher Schmidt Jane M. Palmer Judith Symmons Anne-Marie Gerdes Göran Jönsson Nicholas Hayward QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark The Terrace Eye...
von Hippel Lindau disease (vHL) is caused by a hereditary predisposition to multiple neoplasms, especially hemangioblastomas in the retina and CNS, renal cell carcinomas (RCC), pheochromocytomas, neuroendocrine pancreatic tumours (PNET) endolymphatic sac tumours. Evidence based approaches are needed ensure an optimal clinical care, while minimizing burden for patients their families. This guideline on evidence from international vHL literature extensive research of geno- phenotypic...
About half of patients with metastatic uveal melanoma present isolated liver metastasis, in whom the median survival is 6-12 months. The few systemic treatment options available only moderately prolong survival. Isolated hepatic perfusion (IHP) melphalan a regional option, but prospective efficacy and safety data are lacking.In this multicenter, randomized, open-label, phase III trial, previously untreated metastases from were randomly assigned to receive one-time IHP or best alternative...
Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate circadian clock, masking behavior, melatonin suppression, pupillary light reflex, and sleep/wake cycles. The different functions seem be associated subtypes cells. In rodents, subtype classification has function. primate human retina such so far, not been applied. present study using antibodies against N- C-terminal parts melanopsin,...
Inactivating germ line BRCA1-associated protein-1 (BAP1) mutations have recently been reported in families with uveal or cutaneous malignant melanoma (UMM, CMM), mesothelioma, and meningioma. Although apparently predisposing to a wide range of tumors, the exact tumor spectrum associated BAP1 has yet be established. Here, we report novel splice mutation, c.1708C>G (p.Leu570fs*40), multiple-case Danish UMM family other tumors. Whole-exome sequencing identified an apparent missense mutation...
Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% patients progress to metastatic disease. Therapeutic options for UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) 103 from all sites uveal tract (choroid, ciliary body, iris). While have low mutation burden (TMB), two subsets high TMB seen; one driven by germline MBD4 mutation, another ultraviolet...
Purpose: The American Joint Committee on Cancer (AJCC) staging system has been validated for use as a prognostic parameter in uveal melanoma (UM). We studied whether adding information regarding chromosome 3 and 8q status further enhances the value of this system. Methods: retrospectively cohort 522 patients who had treated UM two different centers between 1999 2015. mean follow-up time was 47.7 months. Cumulative incidence curves were generated regression analyses performed combinations...
Abstract Work in rodents has shown that cultured retinal progenitor cells (RPCs) integrate into the degenerating retina, thus suggesting a potential strategy for treatment of similar degenerative conditions humans. To demonstrate relevance rodent work to large animals, we derived from neural retina domestic pig and transplanted them laser-injured allorecipients. Prior grafting, immunocytochemical analysis showed porcine RPCs widely expressed cell adhesion molecule, as well markers consistent...
We report four previously undescribed families with germline BRCA1-associated protein-1 gene (BAP1) mutations and expand the clinical phenotype of this tumor syndrome. The spectrum in these is predominantly uveal malignant melanoma (UMM), cutaneous (CMM) mesothelioma, as reported for BAP1 mutations. However, mutation carriers from three new families, one family, developed basal cell carcinoma (BCC), thus suggesting inclusion BCC phenotypic This notion supported by finding loss protein...
Abstract Purpose To evaluate the EyeSi ™ simulator in regard to assessing competence cataract surgery. The primary objective was explore all metrics establish a proficiency‐based test with solid evidence. secondary whether skill assessment specific Methods We included 26 ophthalmic trainees (no surgery experience), 11 experienced surgeons (>4000 procedures) and five vitreoretinal surgeons. All subjects completed 13 different modules twice. Simulator were used for assessments. Results...
The melanocyte in the human uvea undergoes rare cases malignant transformation and becomes one of deadliest types melanomas humans. incidence varies between 3 12 per million people highest is found Denmark. uveal melanoma differs many aspects from skin, but lack UV induced mutations failure immunotherapies seems to be most prominent. genetic alterations have provided new tools management this patient group. We can today stratify patients according metastatic risk into a high‐risk group...
In Brief Purpose: To estimate the risk of developing rhegmatogenous retinal detachment (RRD) in fellow eye patients with RRD first and to identify potential factors. Methods: We used Danish National Patient Registry all surgeries performed for Denmark period from January 2000 July 2011. Results: 11,451 cases study period, 8,553 8,081 were identified as primary an annual incidence 13.7 per 100,000 citizens. There was a significant increase number during that mainly explained by cataract...
•Choroidal melanomas more than 3.0 mm in diameter are able to metastasize.•Observation beyond this size limit may alter survival.•Small fatal appear clinically similar reported small nonfatal ones. PurposeTo determine the at which choroidal can metastasize and report characteristics of (SFCM).DesignRetrospective case series.MethodsTen ocular oncology services submitted 45 patients with a melanoma 3 or less thickness 9 largest basal (LBD), when treated, who developed metastases.ResultsMedian...
Uveal melanoma (UM) is the most common intraocular malignancy in adults and shows a high rate of metastatic spread. As randomized clinical trials with immune checkpoint inhibitors (ICI) have not been performed patients UM, we analyzed real-world outcomes nationwide population-based study. Clinical data UM were extracted from Danish Metastatic Melanoma database, database containing unselected records diagnosed Denmark. Survival before (pre-ICI, n = 32) after (post-ICI, 94) approval first-line...
Objective: To investigate overall survival (OS) and health-related quality of life (HRQOL) first-line isolated hepatic perfusion (IHP) compared to best alternative care (BAC) for patients with uveal melanoma liver metastases. Summary Background Data: Approximately half develop metastatic disease, most commonly in the systemic treatment options are limited. Isolated is a locoregional therapy high response rates but unclear effect on (OS). Methods: In this phase III randomized controlled...
Abstract The prognostic value of metabolic tumor burden parameters obtained from 18 F-FDG PET/CT imaging was evaluated in this retrospective national multicenter study patients with metastatic posterior uveal melanoma (PUM) and compared to the largest diameter lesion (LDLM) American Joint Committee on Cancer (AJCC) staging system. Maximal Standard Uptake Value (SUV max ), Metabolic Tumor Volume (MTV), Total Lesion Glycolysis (TLG) were 106 patients. Higher values SUV ( p = 0.007, log-rank),...
Immune cells in primary uveal melanoma (PUM) have mostly been studied enucleated tissue, thereby precluding material from thinner, low-risk PUM tumors for research purposes. Here, we investigated the feasibility of using tumor tissue acquired by transvitreal retinochoroidal (TVRC) biopsies to study immune microenvironment and relation genetic risk class. Collected 41 patients were tested aberrations determine high-risk (n = 19), medium-risk 12), 9) digested flow cytometry analysis cell...