A5085026301- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Retinal Development and Disorders
- Global Cancer Incidence and Screening
- Intraocular Surgery and Lenses
- Reconstructive Surgery and Microvascular Techniques
- Immunotherapy and Immune Responses
- Breast Implant and Reconstruction
- Retinal Diseases and Treatments
- Facial Rejuvenation and Surgery Techniques
- Traumatic Ocular and Foreign Body Injuries
- Breast Lesions and Carcinomas
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- CNS Lymphoma Diagnosis and Treatment
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
The University of Sydney
2015-2024
City Eye Centre
2015-2024
Royal Prince Alfred Hospital
2015-2024
Chris O’Brien Lifehouse
2018-2024
UNSW Sydney
2012
Royal Adelaide Hospital
2008-2010
The University of Adelaide
2008-2010
// Peter Johansson 1 , Lauren G. Aoude Karin Wadt 2 William J. Glasson 3 Sunil K. Warrier Alex W. Hewitt 4, 5 Jens Folke Kiilgaard 6 Steffen Heegaard 6, 7 Tim Isaacs Maria Franchina Christian Ingvar 8 Tersia Vermeulen 9 Kevin Whitehead 10 Christopher Schmidt Jane M. Palmer Judith Symmons Anne-Marie Gerdes Göran Jönsson Nicholas Hayward QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark The Terrace Eye...
Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% patients progress to metastatic disease. Therapeutic options for UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) 103 from all sites uveal tract (choroid, ciliary body, iris). While have low mutation burden (TMB), two subsets high TMB seen; one driven by germline MBD4 mutation, another ultraviolet...
<h3>Objective:</h3> To describe the ocular biometry and determinants of refractive error in an adult population Myanmar. <h3>Methods:</h3> A cross-sectional, population-based survey inhabitants 40 years age over from villages Meiktila District was performed; 2481 eligible participants were identified, 2076 participated study. Biometric components including axial length (AL), anterior chamber depth (ACD), vitreous (VCD), lens thickness (LT) corneal curvature (CC) measured. Lens opalescence...
Objective: To present the clinical features, management, and outcomes in a series of patients with orbital arteriovenous malformations (AVMs).Methods: Clinical records AVMs confirmed using angiography were reviewed as retrospective, noncomparative, interventional case series.Results: Eight (3 women 5 men) unilateral mean age 39 years (median, 36.5 years; range, 26-70 years) reviewed.Findings existed for an average 11.2 before diagnosis included periocular mass (7 patients, 88%); edema,...
Purpose: To determine if a circulating microRNA (miRNA) panel could be used to distinguish between uveal melanoma and nevi. Methods: We report on multicenter, cross-sectional study conducted June 2012 September 2015. The follow-up time was approximately 3 5 years. Blood drawn from participants presenting with nevus (n = 10), localized 50), or metastatic 5). Levels of 17 miRNAs were measured in blood samples using sensitive real-time PCR system. Results: A six (miR-16, miR-145, miR-146a,...
Immediate post-mastectomy breast reconstruction offers benefits; however, complications can compromise outcomes. Intraoperative indocyanine green fluorescence angiography (ICGFA) may mitigate perfusion-related (PRC); its interpretation remains subjective. Here, we examine and develop methods for ICGFA quantification, including machine learning (ML) algorithms complication prediction. video recordings of flap perfusion from a previous study patients undergoing nipple sparing mastectomy (NSM)...
Purpose: To determine the causes of visual impairment and blindness amongst children in schools for blind Myanmar; to identify avoidable blindness; provide spectacles, low vision aids, orientation mobility training ophthalmic treatment where indicated.
Purpose: To report a series of patients who developed late complications secondary to silicone implants used in orbital fracture repairs and review the literature. Design: Retrospective interventional case series. Methods: Analysis records following repair wall fractures with implants. Results: Over 5-year period, 4 were seen arising from implant. There 3 males 1 female whose ages ranged 41–73 years. The time interval between initial insertion implant development was 1.5, 6, 10, 20 noted...
Germline mutations of BRCA1 and BRCA2 predispose individuals to a high risk breast ovarian cancer, elevated other cancers, including those the pancreas prostate. mutation carriers may have increased uveal melanoma (UM) cutaneous (CM), but associations with these cancers in been mixed. Here, we further assessed whether UM CM are associated or by assessing presence, segregation reported/predicted pathogenicity rare germline (variant allele frequency < 0.01) families multiple members affected...
Traumatic rupture of the superior oblique tendon is a rare cause acquired Brown's syndrome. This report describes case traumatic tendon, distal to trochlea, after injury with plant hook. The ruptured was reapproximated. Postoperatively, asymptomatic syndrome developed, although residual function muscle retained. Full-thickness upper eyelid lacerations, especially those caused by hook, must be explored carefully exclude rupture. Careful reapproximation can result in function.
Pathogenic germline variants in protection of telomeres 1 ( POT1 ) result a tumour predisposition syndrome (POT1-TPDS), which includes cutaneous melanoma (CM), glioma, chronic lymphocytic leukaemia (CLL), colorectal cancer, thyroid cancer and sarcoma.1 Through whole-genome sequencing (WGS) 20 Australian individuals affected with both CM uveal (UM), our study identified two truncating . Functional analyses assessing telomere length indicated longer variant carriers, compared healthy...
To investigate the efficacy of intravitreal bevacizumab for treatment neovascular age-related macular degeneration (AMD) using an as required dosing regimen.A retrospective study 210 patients (231 eyes) with choroidal neovascularization resulting from neovasacular AMD. Patients were treated 1.25 mg at a vitreoretinal practice in Adelaide, South Australia. followed up 2-4 weeks and then 1-month intervals; repeat injections offered event recurrence. Recurrence was defined either decrease...
Purpose: To determine the rate of ocular surface squamous neoplasia in all pterygium specimens a 2-year period at single tertiary hospital metropolitan Brisbane. Secondary outcomes measured included percentage tissue samples undergoing histological analysis and clinical suspicion dysplastic change. Method: Retrospective chart review was undertaken for surgery performed between January 2009 October 2010 Princess Alexandra Hospital The neoplasia, number sent histopathology analysis, changes...
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Background and purpose: Gold standard sentinel lymph node (SLN) mapping for breast cancer involves technetium-99m (99mTc) but has drawbacks. Indocyanine green (ICG) fluorescence allows real-time visualisation of lymphatics nodes, routine use is not established. This study compares equivalency ICG to 99mTc. Methods: Prospective non-inferiority trial early patients undergoing SLN biopsy with 99mTc (2021-2023). Number SLNs identified, including metastatic rate failed mapping, were compared....