A5027557326- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Advanced biosensing and bioanalysis techniques
- Cutaneous Melanoma Detection and Management
- Retinal Development and Disorders
- Nasolacrimal Duct Obstruction Treatments
- Corneal Surgery and Treatments
- Cell Image Analysis Techniques
- Advanced Biosensing Techniques and Applications
- Ocular Disorders and Treatments
- Genomics and Rare Diseases
- Retinal Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer and Skin Lesions
- Nanoplatforms for cancer theranostics
City Eye Centre
2019-2024
Royal Children's Hospital
2024
Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% patients progress to metastatic disease. Therapeutic options for UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) 103 from all sites uveal tract (choroid, ciliary body, iris). While have low mutation burden (TMB), two subsets high TMB seen; one driven by germline MBD4 mutation, another ultraviolet...
Purpose: To determine if a circulating microRNA (miRNA) panel could be used to distinguish between uveal melanoma and nevi. Methods: We report on multicenter, cross-sectional study conducted June 2012 September 2015. The follow-up time was approximately 3 5 years. Blood drawn from participants presenting with nevus (n = 10), localized 50), or metastatic 5). Levels of 17 miRNAs were measured in blood samples using sensitive real-time PCR system. Results: A six (miR-16, miR-145, miR-146a,...
To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.
Ectopic lacrimal glands are rare, particularly intraocularly. We present the case of an infant who presented with a fleshy, vascular intraocular lesion and subsequently developed secondary glaucoma. The patient underwent primary enucleation, which was preferred over diagnostic biopsy due to likelihood malignancy poor visual prognosis. Histology confirmed gland choristoma. This highlights challenges in clinical diagnosis lesions, potentially aggressive nature benign tumours such as choristomas.
e13534 Background: Germline mutations in the BRCA1-associated protein (BAP1) gene are linked to a large spectrum of cancers, defined as BAP1 tumour predisposition syndrome (BAP1-TPDS). The cancers usually occurring kindreds with BAP1-TPDS uveal melanoma, mesothelioma, cutaneous renal cell carcinoma, cholangiocarcinoma and meningioma. A 2017 review identified only 87 probands worldwide germline mutations. Methods: To better understand frequency BAP1-TPDS, we took systematic sequencing...