A5032607464- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Black Holes and Theoretical Physics
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- Cosmology and Gravitation Theories
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- High-Energy Particle Collisions Research
- Immunotherapy and Immune Responses
- Physics of Superconductivity and Magnetism
- Atomic and Subatomic Physics Research
- Cancer Genomics and Diagnostics
- Biosimilars and Bioanalytical Methods
- Computational Physics and Python Applications
- Superconducting Materials and Applications
- Astrophysics and Cosmic Phenomena
- Particle Detector Development and Performance
- Algebraic structures and combinatorial models
- Quantum, superfluid, helium dynamics
- Particle Accelerators and Free-Electron Lasers
- Computational Drug Discovery Methods
- Cutaneous Melanoma Detection and Management
- Particle accelerators and beam dynamics
- melanin and skin pigmentation
University of California, San Francisco
2019-2024
Moffitt Cancer Center
2022-2024
UCSF Helen Diller Family Comprehensive Cancer Center
2020-2024
National Tsing Hua University
1997-2006
National Center for Theoretical Sciences
1998-2005
National Center for Theoretical Sciences, Physics Division
2004-2005
University of Illinois Chicago
1991-2003
Lawrence Berkeley National Laboratory
2002-2003
University of California, Berkeley
2002-2003
SLAC National Accelerator Laboratory
2000-2001
A new approach to left-right symmetric models is proposed, where the discrete-symmetry- and $\mathrm{SU}{(2)}_{R}$-breaking scales are decoupled from each other. This changes spectrum of physical Higgs bosons which leads different patterns for gauge hierarchies in $\mathrm{SU}{(2)}_{L}\ensuremath{\bigotimes} \mathrm{SU}{(2)}_{R}\ensuremath{\bigotimes} \mathrm{SU}{(4)}_{C}$ SO(10) models. Most interesting two symmetry-breaking chains with an intermediate $\mathrm{U}{(1)}_{R}$ symmetry. These...
We calculate a new type of two-loop contribution to the electric dipole moments electron and neutron in supersymmetric theories. The contributions are originated from potential $\mathrm{CP}$ violation trilinear couplings Higgs bosons scalar-top or scalar-bottom quarks. These did not receive stringent constraints directly. induced through mechanism analogous that due Barr Zee [Phys. Rev. Lett. 65, 21 (1990)]. find observable effects for sizable portion parameter space related third generation...
We propose a new approach to the left-right-symmetric models of weak interactions where parity-and ${\mathrm{SU}(2)}_{R}$-breaking scales are decoupled from each other. This changes spectrum Higgs bosons, which in turn affects evolution various gauge coupling constants with energy. has profound implications for mass hierarchies partial unification based on ${\mathrm{SU}(2)}_{L}\ifmmode\times\else\texttimes\fi{}{\mathrm{SU}(2)}_{R}\ifmmode\times\else\texttimes\fi{}{\mathrm{SU}(4)}_{C}$ and...
A new approach to SO(10) grand unification was recently proposed by three of the authors (D.C., R.N.M., and M.K.P.), where mass scale ${M}_{P}$ at which D-parity symmetry present in group breaks right-handed currents. In contrast with conventional treatment model, SU(2${)}_{\mathrm{L}}$\ifmmode\times\else\texttimes\fi{}SU(2${)}_{\mathrm{R}}$\ifmmode\times\else\texttimes\fi{}G [G is SU(4${)}_{\mathrm{C}}$ or...
We present an extension of the left-right-symmetric model by including extra singlet quarks and leptons, which leads to calculable ${\mathrm{W}}_{\mathrm{L}}$-${\mathrm{W}}_{\mathrm{R}}$ mixing ultralight Dirac mass for neutrino. For a ${\mathrm{W}}_{\mathrm{R}}$ in tera-electron-volt range, neutrino masses can be right range explain solar puzzle via Mikheyev-Smirnov-Wolfenstein oscillation amplification mechanism. Crucial our results is ``see-saw''-type mechanism smallness d-quark masses.
Abstract Cutaneous squamous cell carcinoma is a form of skin cancer originating from keratinocytes in the skin. It second most common type and responsible for an estimated 8000 deaths per year United States. Compared to other subtypes with similar incidences death tolls, our understanding somatic mutations driving cutaneous limited. The main challenge that these tumors have high mutation burdens, primarily consequence UV-radiation-induced DNA damage sunlight, making it difficult distinguish...
A subset of patients with diffuse large B-cell lymphoma (DLBCL) treated CD19 chimeric antigen receptor (CAR) T-cell therapy have poor clinical outcomes. We report serum proteins associated severe immune-mediated toxicities and inferior responses in 146 DLBCL axicabtagene ciloleucel. develop a simple stratification based on pre-lymphodepletion C reactive protein (CRP) ferritin to classify into low-, intermediate-, high-risk groups. observe that the category were more likely grade ≥3 had...
The two--loop mechanism of Bjorken and Weinberg is used to constrain flavor changing neutral Higgs bosons. We calculate the complete set diagrams for rare decay $\mu \rightarrow e + \gamma$ induced by such bosons, arbitrary top masses. analytic result limits on masses some recent models with specific ansatz about couplings. For example, in Cheng--Sher scenario multi-Higgs doublet models, all bosons possess ($f_i \leftrightarrow f_j)$ couplings proportional $\sqrt{m_i m_j}$. find that present...
We analyze the possibility of solving strong CP problem by imposing parity symmetry. Some simple realizations such a scheme are given and interesting phenomenological cosmological consequences discussed.
We show that in see-saw models of neutrino mass a la SUSY SO(10), the observed large mixing atmospheric neutrinos naturally leads to b-s transitions. If associated new CP phase turns out be large, this contributions can drastically affect violation some B decay channels yielding beta and gamma angles unitarity triangle. They even produce sizeable asymmetries modes which are not violating standard model context. Hence makes observations low energy effect potentially promising spite agreement...
We calculate the dominant contributions to muon $g\ensuremath{-}2$ at two-loop level due a generic pseudoscalar boson that may exist in any exotic Higgs sector most extensions of standard model. The leading effect comes from diagrams Barr-Zee type. A sufficiently light can give rise as large electroweak contribution which is measurable next round experiments. Through we here, anticipated improved data recent future on put best limit possible existence physics beyond
We investigate a simple model of neutrino mass based on $\mathrm{SU}(3{)}_{C}\ensuremath{\bigotimes}\mathrm{SU}(3{)}_{L}\ensuremath{\bigotimes}\mathrm{U}(1{)}_{X}$ gauge unification. The Yukawa coupling the has automatic lepton-number symmetry which is broken only by self-couplings Higgs boson. At tree level, spectrum contains three Dirac fermions, one massless and two degenerate in mass. two-loop neutrinos obtain Majorana masses correct tree-level result naturally gives rise to an inverted...
<title>Abstract</title> Chimeric antigen receptor (CAR) T cell therapies have revolutionized B malignancy treatment, but subsets of patients with large lymphoma (LBCL) experience primary resistance or relapse after CAR treatment. To uncover tumor microenvironment (TME)-induced mechanisms, we examined patients’ intratumoral immune infiltrates and observed that elevated levels immunoregulatory macrophages in pre-infusion biopsies are correlated poor clinical responses. cell-produced...
We investigate the possibility of detecting CP-odd angular correlations in various decay modes neutral Higgs boson including a ZZ pair, ${\mathit{W}}^{+}$${\mathit{W}}^{\mathrm{\ensuremath{-}}}$ or heavy quark pair. It is natural way to probe CP character once it identified. Final state interactions (i.e., absorptive amplitude) are not required such correlations. As an illustrative example we take fundamental source nonconservation be Yukawa couplings fermions. A similar correlation process...
We present an analysis of the discovery reach for supersymmetric particles at upgraded Tevatron collider, assuming that SUSY breaking results in universal soft parameters grand unification scale, and lightest particle is stable neutral. first a review literature, including issues unification, renormalization group evolution supersymmetry effect radiative corrections on effective low energy couplings masses theory. consider experimental bounds coming from direct searches those arising...
We calculate the complete set of two-loop diagrams in multi-Higgs-doublet model for electron electric dipole moment including both vertices $H\ensuremath{\gamma}\ensuremath{\gamma}$ and $\mathrm{HZ}\ensuremath{\gamma}$ induced by unphysical-charged-Higgs-boson $W$ contributions. These additional amplitudes modify result previously studied Barr Zee.
We study an important contribution to the electric dipole moment (EDM) of electron (or quarks) at two-loop level due $W$-EDM in recently proposed scenario split supersymmetry. This is independent Higgs mass, and it can enhance previous estimation (neutron) EDM by 20--$50%$ (40--$90%$). Our formula new its analytical form.
Spatial transcriptomic technologies, such as the Visium platform, measure gene expression in different regions of tissues. Here, we describe new software, STmut, to visualize somatic point mutations, allelic imbalance, and copy number alterations data. STmut is tested on fresh-frozen data, formalin-fixed paraffin-embedded (FFPE) tumors with without matching DNA sequencing Copy inferred all conditions, but chemistry FFPE platform does not permit analyses single nucleotide variants. Taken...