A5058790135- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Biosimilars and Bioanalytical Methods
- Estrogen and related hormone effects
- Orthopedic Surgery and Rehabilitation
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Statistical Methods and Inference
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- Spine and Intervertebral Disc Pathology
- Machine Learning in Healthcare
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Elbow and Forearm Trauma Treatment
- Medical Malpractice and Liability Issues
- Menopause: Health Impacts and Treatments
- Advanced Causal Inference Techniques
- Sepsis Diagnosis and Treatment
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Cancer-related cognitive impairment studies
Kite (United States)
2024
University of Michigan
2016-2022
VA Center for Clinical Management Research
2020
Michigan Medicine
2020
VA Ann Arbor Healthcare System
2020
Morishita Jintan (Japan)
2020
FishBase Information and Research Group
2020
Green Cross International
2007
Dong-A University
2007
Oncolytic viruses (OVs) are selected or designed to eliminate malignancies by direct infection and lysis of cancer cells. In contrast this concept tumor viral infection, we observed that a significant portion the in vivo killing activity two OVs, vesicular stomatitis virus (VSV) vaccinia is caused indirect uninfected Shortly after administering oncolytic limited coincident with loss blood flow interior correlated induction apoptosis Transcript profiling tumors showed resulted dramatic...
A subset of patients with diffuse large B-cell lymphoma (DLBCL) treated CD19 chimeric antigen receptor (CAR) T-cell therapy have poor clinical outcomes. We report serum proteins associated severe immune-mediated toxicities and inferior responses in 146 DLBCL axicabtagene ciloleucel. develop a simple stratification based on pre-lymphodepletion C reactive protein (CRP) ferritin to classify into low-, intermediate-, high-risk groups. observe that the category were more likely grade ≥3 had...
<h3>Objective:</h3> To test efficacy and safety of atorvastatin in subjects with clinically isolated syndrome (CIS). <h3>Methods:</h3> Subjects CIS were enrolled a phase II, double-blind, placebo-controlled, 14-center randomized trial testing 80 mg on clinical brain MRI activity. Brain MRIs performed quarterly. The primary endpoint (PEP) was development ≥3 new T2 lesions, or one relapse within 12 months. meeting the PEP offered additional weekly interferon β-1a (IFNβ-1a). <h3>Results:</h3>...
Abstract BACKGROUND The risk for cardiovascular events increases within hours of near-roadway exposures. We aimed to determine the traffic-related air pollution (TRAP) and biological mechanisms involved if reducing particulate matter &lt;2.5 µm (PM2.5) inhalation is protective. METHODS Fifty healthy-adults underwent multiple 2-hour exposures (Tuesdays Fridays) in Ann Arbor during 2 separate weeks (randomized wear an N95 respirator 1 week). Monday both weeks, participants rested exam room...
Delayed autologous breast reconstruction is commonly recommended in patients requiring postmastectomy radiation. This study examines gross and histologic changes the skin of who have undergone radiation to help determine when radiation-induced begin stabilize. A prospective pilot was conducted on eight with invasive cancer required mastectomy radiotherapy. At time 2, 4, 6, 8, 12 months after completion radiotherapy, a punch biopsy taken from radiated each patient. Serial standardized...
The Wrist and Radius Injury Surgical Trial (WRIST) collaboration is the largest clinical trial ever conducted in hand surgery. We applied data from this study to examine relationship between functional outcomes patient satisfaction after treatment of distal radial fractures. Patients aged 60 years older with isolated fractures were enrolled at 24 health systems. Grip strength arc wrist motion measured treatment. Michigan Hand Outcomes Questionnaire was used measure satisfaction. Receiver...
Hormone receptor-positive (HR+) breast cancers express the estrogen (ERα) and/or progesterone (PgR) receptors. Inherited single nucleotide polymorphisms (SNPs) in ESR1, gene encoding ERα, have been reported to predict tamoxifen effectiveness. We hypothesized that these associations could be attributed altered tumor gene/protein expression of ESR1/ERα and SNPs PGR PGR/PgR expression. Formalin-fixed paraffin-embedded cancer specimens were analyzed for ESR1 transcript by reverse transcription...
Despite appropriate treatment, many patients who sustain distal radius fractures (DRFs) report persistent wrist pain. Chronic musculoskeletal pain is among the leading health problems in elderly population associated with significant personal and societal burden.To identify modifiable preoperative factors that are significantly developing chronic pain.This a secondary analysis of Wrist Radius Injury Surgical Trial (WRIST), randomized multicenter clinical trial 24 study sites United States,...
<h3>Importance</h3> Optimal treatment for traumatic finger amputation is unknown to date. <h3>Objective</h3> To use statistical learning methods estimate evidence-based assignment rules enhance long-term functional and patient-reported outcomes in patients after of fingers distal the metacarpophalangeal joint. <h3>Design, Setting, Participants</h3> This decision analytical model used data from a retrospective cohort study 338 consenting adult who underwent revision or replantation at 19...
Purpose: Fine particulate matter (PM 2.5 ) air pollution is a leading risk factor for cardiovascular disease. Even low levels common to millions of Americans pose health risks. However, no study has tested protective measures such as in-home portable cleaners (PACs) among at-risk cardiac patients. We conducted pilot phase the Cardiac Rehabilitation Air Filter Trial (CRAFT)—a randomized, double-blind, crossover outpatient rehabilitation patients at Michigan Medicine. Methods: During routine...
Background: Evidence-based practices in medicine are linked with a higher quality of care and lower health cost. For trigger finger, identifying patient factors associated nonadherence to evidence-based will aid physicians treatment decisions. The objectives were (1) determine nonadherence, (2) examine the success rates steroid injections, (3) evaluate economic consequences recommendations. Methods: authors used data from Clinformatics DataMart database 2010 2017 conduct population-based...
Abstract BACKGROUND Spine stereotactic body radiotherapy (sSBRT) is commonly limited to 1 or 2 vertebral levels given a paucity of efficacy and toxicity data when more than are treated. OBJECTIVE To prove our hypothesis that multilevel sSBRT could provide similar rates local control (LC) (primary endpoint) as single-level treatment using the same clinical target, planning organ-at-risk volumes. METHODS We analyzed consecutive cases treated from 2013 2017. Time-to-event outcomes for were...
<h3>Importance</h3> Stenosing tenosynovitis (trigger finger) affects approximately 2% of the population. Given prevalence trigger finger and rising health care costs, adherence to cost-effective evidence-based treatment algorithm will permit better outcomes allocation resources. <h3>Objectives</h3> To examine patterns for determine surgeon-level patient-level factors that influence treatment. <h3>Design, Setting, Participants</h3> This retrospective population-based cohort study examined...
Dynamic treatment regimes are a set of time-adaptive decision rules that can be used to personalize across multiple stages care. Grounded in causal inference methods, dynamic identify variables differentiate the effect and may tailor treatments individuals based on patient's own characteristics - thereby representing an important step toward personalized medicine. In this manuscript we introduce Penalized Spline-Involved Tree-based Learning, which seeks improve upon existing tree-based...
<p>Table S3 shows the Multivariable Cox Regression analysis of overall (A) and progression free survival (B) using CRP Ferritin risk categories</p>
<p>Figure S1 shows the serum markers associated with severe CRS and ICANS</p>
<p>Table S2 shows Multivariable analysis of grade >2 ICANS across the three risk groups.</p>
<p>Figure S3 shows that prophylactic steroids do not improve efficacy outcomes in high risk patients</p>
<p>Figure S2 shows the optimal CRP (A) and ferritin (B) cut offs for overall survival</p>