A5100786359- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Phytochemistry and Bioactivity Studies
- Metabolomics and Mass Spectrometry Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Oral microbiology and periodontitis research
- Phytochemistry and Biological Activities
- Food Quality and Safety Studies
- Glycosylation and Glycoproteins Research
- Medicinal Plant Pharmacodynamics Research
- Genetic Associations and Epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
- Robotic Locomotion and Control
- Magnolia and Illicium research
- Biopolymer Synthesis and Applications
- Flavonoids in Medical Research
- Alzheimer's disease research and treatments
- Plant Physiology and Cultivation Studies
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Plant Gene Expression Analysis
- Bioactive natural compounds
Guang’anmen Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Nanjing University of Chinese Medicine
2018-2023
Northeast Forestry University
2023
First Affiliated Hospital of Zhengzhou University
2022
China Academy of Chinese Medical Sciences
2021
Shanghai Jiao Tong University
2019-2021
Ocean University of China
2016
Henan University of Traditional Chinese Medicine
2016
Carnegie Mellon University
2015
Background: Lacunar stroke accounts for a quarter of all strokes, but little is known about the underlying pathological mechanisms. Analysis serum metabolites may allow better understanding biological processes. Mendelian randomization (MR) can provide information on causality associations. Aims: To identify causal relationships between and lacunar stroke. Methods: We applied two-sample MR analysis to evaluate 486 The inverse-variance weighted (IVW) method was used estimate relationship...
As one of the major abiotic stresses, salinity stress may affect physiology and biochemical components Apocynum venetum L. To systematically evaluate quality Apocyni Veneti Folium (AVF) from perspective physiological wide variety bioactive response to various concentrations salt stress, this experiment was arranged on basis ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) technology multivariate statistical analysis. Physiological characteristics...
Ophiopogonis Radix, also known as Mai-dong in Chinese, was a commonly used traditional Chinese medicine (TCM) and functional health food. Two products of Radix are largely produced the Sichuan Zhejiang province, which called "Chuan maidong (CMD)" "Zhe (ZMD)" respectively. To distinguish evaluate quality CMD ZMD, an analytical method based on ultra-fast performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry (UFLC-QTRAP-MS/MS) established for...
Schisandrae Chinensis Fructus, also called wuweizi in China, was a widely used folk medicine Korea, and Russia. Due to the limited natural resources huge demand of wuweizi, people tend cultivate protect this species. However, quality wild cultivated herbs same species may change. Little attention has been paid comparing based on simultaneous determination its active components, such as lignans organic acids. An analytical method UFLC-QTRAP-MS/MS for 15 including 11 (schisandrin, gomisin D,...
Abstract Introduction Ginseng Flos (GF), the flower bud of Panax ginseng , is a worthy functional food with medicinal potential. A few studies have focused on comprehensive and systematic analysis its major bioactive constituents. Objective The aims are to develop methods ultra‐fast liquid chromatography coupled triple quadrupole‐time flight tandem mass spectrometry (UFLC‐Triple TOF‐MS/MS) quadrupole‐linear ion trap (UFLC‐QTRAP‐MS/MS) for qualitative quantitative saponins in GF. Methodology...
Licorice is one of the ancient and most frequently applied herbs for its diverse phytochemicals. At present, wild resources licorice have rapidly declined with increasing demand proportion cultivated products in market quickly growing. However, different level chemical composition between may result discrepancy quality pharmacological activity. Therefore, an ultra-fast liquid chromatography coupled triple quadrupole-time flight tandem mass spectrometry (UFLC-Triple TOF-MS/MS) method combined...
Preoperative assessment of tumor invasiveness is essential to avoid overtreatment for patients with small-sized ground-glass nodules (GGNs) 10 mm or less in diameter. However, it difficult determine the pathological state by computed tomography (CT) examination alone. Aberrant glycans has emerged as a tool identify novel potential disease biomarkers. In this study, we used lectin microarray-based strategy investigate whether glycosylation changes plasma immunoglobulin G (IgG) provide...
Abstract In this study, a fingerprint-activity relationship between chemical fingerprints and hepatoprotective activity was established to evaluate the quality of salt-treated Apocyni Veneti Folium (AVF). Characteristic AVF samples exposed different concentrations salt were generated by ultrafast liquid chromatography tandem triple time-of-flight mass/mass spectrometry (UFLC-Triple TOF-MS/MS), similarity analysis performed based on common characteristic peaks hierarchical clustering (HCA)....
Panacis Japonici Rhizoma (PJR) contains various kinds of saponins, which possesses extensive pharmacological activities, but studies comprehensive analysis its saponins were limited. Thus, ultra-fast liquid chromatography coupled with triple quadrupole-time flight tandem mass spectrometry (UFLC-Triple TOF-MS/MS) and quadrupole-linear ion trap (UFLC-QTRAP-MS/MS) methods established for the qualitative quantitative in PJR, separately. Fifty three PJR identified by UFLC-Triple TOF-MS/MS method,...
Magnoliae Officinalis Cortex (MOC) is a commonly used traditional Chinese herbal medicine, which always preliminarily processed by “sweating”. To explore the effects of primary processing on chemical constituents in MOC and potential markers for differentiating samples “sweating” “non sweating”, method proposed based ultra fast liquid chromatography-triple quadrupole-time flight mass spectrometry (UFLC-Triple TOF MS/MS) gas quadrupole (GC-MS/MS) coupled with multivariate statistical...
A method, for determination of saponins, amino acids and nucleosides in Panacis Japonici Rhizoma ultra fast liquid chromatography with triple quadrupole linear ion trap mass spectrometry (UFLC-QTRAP-MS/MS), was established to investigate the effect different processing methods on target components Rhizoma. The chromatographic separation performed a XBridgeC₁₈(4.6 mm×100 mm, 3.5 μm) at 30 °C gradient elution 0.1% formic acid solution-0.1% acetonitrile, flow rate 0.8 mL·min⁻¹, using...
An analytical method based on UFLC-QTRAP-MS/MS was established for simultaneous determination of thirty-three components including steroidal saponins, homoisoflavonoids, amino acids and nucleosides in Ophiopogonis Radix. Thirty-three target commercial medicinal materials Maidong were comparative analysis. Synergi™ Hydro-RP 100 column (2.0 mm × 100 mm, 2.5 μm) used with 0.1% formic acid solution-0.1% acetonitrile gradient elution at a flow rate 0.4 mL·min⁻¹. In addition, multiple reaction...
An analytical method based on UFLC-QTRAP-MS/MS was developed for simultaneous determination of fifteen components including eleven lignans (schizantherin B, schisandrol schizandrin C, γ-schisandrin, deoxyschizandrin, schisantherin, schisandrin, schisanhenol, gomisin D, J, and angeloylgomisin H) organic acids (S)-malic acid, D(-)-tartaric protocatechuic quinic acid) in Schisandrae Chinensis Fructus. Samples from different product specifications were evaluated analyzed. The chromatographic...
Traditional yeast fermentation process is becoming a big bottleneck recently in Chinese liquor industry, because of the low efficiency and high cost human labor with little automation. An intelligent automatic system based on novel designed structure, specialized robot wireless multi-sensor data acquisition system, has been introduced this paper. Standardized parts are used mechanical to achieve convenient production. control for decision-makers monitor factory status command movement...
The F-box gene family is abundant in plants and crucial for plant growth development. However, two questions prevail: Which genes are involved regulating biological processes? How do these regulate such In this study, we characterized the identified 240 birch (Betula platyphylla Suk.) via HMMER analysis. According to C-terminal conserved domains, members were divided into 10 subfamilies. Through phylogenetic analysis, proteins clustered eight evolutionary branches. Synteny analyses suggested...