A5100694618- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Circular RNAs in diseases
- bioluminescence and chemiluminescence research
- Ear Surgery and Otitis Media
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Noise Effects and Management
- Plant Molecular Biology Research
- Hydrogen's biological and therapeutic effects
- Antenna Design and Analysis
- Advanced biosensing and bioanalysis techniques
- Speech and Audio Processing
- Plant responses to water stress
- Immune Response and Inflammation
- Aluminum toxicity and tolerance in plants and animals
- Fibroblast Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
XinHua Hospital
2018-2024
Shanghai Jiao Tong University
2009-2023
Shanghai First People's Hospital
2011-2014
Shanghai Sixth People's Hospital
2009-2013
University at Buffalo, State University of New York
2011
Conclusions: Mouse cochleae are highly resistant to systemicallyadministered cisplatin. However, cochlear lesions can be produced effectively in mice when cisplatin is applied locally through the round window niche or tympanum. Objective: To explore optimal approach for creating cisplatin-induced mice. Materials and methods: Cisplatin was administered adult C57BL/6J via four approaches: (1) transtympanic injection, (2) (3) intraperitoneal injection (i.p.) at 4 mg/kg/day consecutive days, (4)...
Age-related hearing loss (ARHL) is the most prevalent sensory disorder in elderly. Currently, no treatment can effectively prevent or reverse ARHL. Aging auditory organs are often accompanied by exacerbated oxidative stress and metabolic deterioration. Here, we report effect of deuterated oxygen (D2O), also known as "heavy water", mouse models Supplementing normal diet with 10% D2O from 4 to 9 weeks age lowered thresholds at selected frequencies treated mice compared untreated control group....
Cisplatin belongs to platinum-based drugs and is widely used in cancer chemotherapy. Ototoxicity one of the major dose limiting side-effects cisplatin. For toxicity occur cisplatin must first be transported from bloodstream into cochlear cells. Three copper transporters are considered pathways for regulating uptake translocation cells: Ctr1, ATP7A ATP7B. Our recent study with organotypic cultures shows that hair cells can destroyed by at low concentrations 10μm 100μn. However, high doses...
Cochlear ribbon synapses play a pivotal role in the prompt and precise acoustic signal transmission from inner hair cells (IHCs) to spiral ganglion neurons, while noise aging can damage synapses, resulting sensorineural hearing loss.Recently, we described reduced fibroblast growth factor 22 (FGF22) augmented myocyte enhancer 2D (MEF2D) an ototoxicity mouse model with impaired synapses.Here, investigated mechanisms that underlie FGF22/MEF2D-regulated impairment of synapses.We generated...
Autophagy and apoptosis have a complex interplay in the early embryo development. The development of spiral ganglion neurons (SGNs) addition to Corti’s organ mammalian cochlea remains crucial first two-week postnatal period. To investigate roles autophagy SGNs, light microscopy was used observe morphological changes SGNs. number SGNs decreased from P1 P7 plateaued P10 P14. Immunohistochemistry results revealed positive expression cleaved-caspase3, bcl-2, microtubule-associated protein chain...
The acceptable noise level (ANL) was defined by subtracting the background (BNL) from most comfortable listening (MCL) (ANL = MCL − BNL). This study compared ANL obtained through different methods in 20 Chinese subjects with normal hearing. tested Mandarin speech materials using a loudspeaker or earphones, each subject himself audiologist. presentation and response modes were as follows: (1) self-adjusted levels audiometer controls (LS method); (2) signaling audiologist to adjust (LA (3)...