A5045305308- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- Urological Disorders and Treatments
- MRI in cancer diagnosis
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Urologic and reproductive health conditions
- Connective Tissue Growth Factor Research
- Cytokine Signaling Pathways and Interactions
- Pelvic floor disorders treatments
- Infectious Diseases and Mycology
- Dermatologic Treatments and Research
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- Pressure Ulcer Prevention and Management
- Anorectal Disease Treatments and Outcomes
- Organ Donation and Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Asthma and respiratory diseases
- Urinary Tract Infections Management
Tarzana Treatment Centers
2024
Cedars-Sinai Medical Center
2012-2017
Vanderbilt University
2007-2009
Vanderbilt University Medical Center
2004-2008
Monroe Carell Jr. Children's Hospital
2005-2007
Abstract Transforming growth factor–β (TGF-β) isoforms are factors that function physiologically to regulate development, cellular proliferation, and immune responses. The role of TGF-β signaling in mammary tumorigenesis is complex, as has been reported both a tumor suppressor promoter. To elucidate the gland tumorigenesis, metastasis, gene encoding type II receptor, Tgfbr2, was conditionally deleted epithelium (Tgfbr2MGKO). Loss Tgfbr2 results lobular-alveolar hyperplasia developing...
Abstract Mechanisms of androgen dependence the prostate are critical to understanding cancer progression independence associated with disease mortality. Transient elevation transforming growth factor-β (TGF-β) occurs after ablation. To determine role TGF-β on response ablation, conditional type II receptor knockout mouse models epithelia (Tgfbr2NKX3.1KO) and stromal fibroblasts (Tgfbr2fspKO) were used. After castration, prostates Tgfbr2NKX3.1KO mice had apoptosis levels similar those...
No AccessJournal of UrologyBasic Science1 Oct 2008Temporal-Spatial Protein Expression in Bladder Tissue Derived From Embryonic Stem Cells John C. Thomas, Siam Oottamasathien, H. Makari, Lindsay Honea, Ali-Reza Sharif-Afshar, Yongqing Wang, Cyrus Adams, Marcia L. Wills, Neil A. Bhowmick, Mark W. Brock, Simon Hayward, Robert J. Matusik, and Pope ThomasJohn Thomas Department Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee Division Pediatric Urology, Monroe Carell...
Purpose To improve spatial resolution and image quality of diffusion‐weighted (DW) MRI in detecting low‐risk prostate cancer (lrPC) patients undergoing active surveillance protocol (AS‐PC), we propose the application a diffusion‐prepared balanced steady‐state free precession (bSSFP) technique capable multishot acquisition. Methods Diffusion‐prepared bSSFP was compared with single‐shot DW echo planar imaging (SS‐DW‐EPI) at two prescribed resolutions (2.1 × 2.1 3.5mm 3 , 0.9 3.5 mm ) nine...
Rapid bladder growth associated, partial urethral obstruction and embryonic development entail stromal-epithelial interactions involving signaling by the cytokine transforming factor-beta (TGF-beta). However, to our knowledge role of TGF-beta in stromal hyperplasia hypertrophy is not understood.In an effort understand specific stroma a fibroblast conditional knockout mouse type II receptor gene, Tgfbr2(/spko), was generated using Cre-lox methodology. Bladders from 18, 7 8-week-old mice were...
ObjectivesHigh-resolution prostate imaging may allow for detection of subtle changes in tumor size, decrease the reliance on biopsies, and help define boundaries during ablation. This pilot clinical trial evaluates a novel high-resolution MRI small, biopsy-proven tumors.MethodsOur team developed software that can be loaded any modern to generate high resolution diffusion-weighted sequences (HR-DWI), which were compared standard sequence (S-DWI) prospective active surveillance patients....
We examined the role of transforming growth factor-beta in urothelial and bladder development. Transforming signaling was attenuated compartment subsequent effects were a tissue recombination model.Urothelium cultured from adult rat bladders transfected with control vector C7Delta or mutant DNIIR (dominant negative receptor II). Grafts created by recombining urothelium plus embryonic day 18 mesenchyma placed beneath renal capsule athymic mouse hosts. harvested at 21 42 days. Final tissues...
The purpose of this study was to determine the impact resident teaching on outcomes mid-urethral sling surgery.A retrospective review female patients who underwent an outpatient transobturator (TOT) synthetic procedure with and without concomitant prolapse repair by two surgeons (JA, KE) in a tertiary pelvic medicine practice performed. Total time (TPT = from incision closure including placement any procedure), estimated blood loss (EBL), postoperative complications urinary retention, mesh...
To describe our initial experience with a novel modification of the Mitrofanoff conduit technique utilizing Yang-Monti ileovesicostomy and serosa lined extramural tunnel T-pouch to create continent catheterizable stoma in patients prior enterocystoplasty.A 14 cm segment bowel was harvested, distal 4 divided reconfigured technique. The remaining folded into U secured serosal basting stitch. Half tube is laid trough U-shaped secured. Next, incised along anti-mesenteric border for length tube....
You have accessJournal of UrologyImaging/Radiology: Uroradiology II1 Apr 2016PD06-08 PROSPECTIVE TRIAL TO EVALUATE A HIGH RESOLUTION DIFFUSION-WEIGHTED MRI IN PROSTATE CANCER PATIENTS Ali Reza Sharif-Afshar, Christopher Nguyen, Tom Feng, Lucas Payor, Zhaoyang Fan, Rola Saouaf, Debiao Li, and Hyung Kim Sharif-AfsharAli Sharif-Afshar More articles by this author , NguyenChristopher Nguyen FengTom Feng PayorLucas Payor FanZhaoyang Fan SaouafRola Saouaf LiDebiao Li KimHyung View All Author...
You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation, Surgery (II)1 Apr 20132315 TRENDS IN BODY MASS INDEX AFTER DONOR NEPHRECTOMY Christopher Dru, Mehran Movassaghi, Steven Koopman, Ali Reza Sharif Afshar, Lauren Wood, and Gerhard Fuchs DruChristopher Dru Los Angeles, CA More articles by this author , MovassaghiMehran Movassaghi KoopmanSteven Koopman AfsharAli Afshar WoodLauren Wood FuchsGerhard View All Author...
<div>Abstract<p>Mechanisms of androgen dependence the prostate are critical to understanding cancer progression independence associated with disease mortality. Transient elevation transforming growth factor-β (TGF-β) occurs after ablation. To determine role TGF-β on response ablation, conditional type II receptor knockout mouse models epithelia (Tgfbr2<sup>NKX3.1KO</sup>) and stromal fibroblasts (Tgfbr2<sup>fspKO</sup>) were used. After castration,...
Supplementary Figure 1 from Effect of Conditional Knockout the Type II <i>TGF-β</i> Receptor Gene in Mammary Epithelia on Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation Metastasis