A5066659525- Respiratory viral infections research
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Eosinophilic Esophagitis
- Parasitic Infections and Diagnostics
- Inflammasome and immune disorders
- Amoebic Infections and Treatments
- Probiotics and Fermented Foods
- Insects and Parasite Interactions
- Behavioral Health and Interventions
- Respiratory Support and Mechanisms
- Antimicrobial Peptides and Activities
- Vagus Nerve Stimulation Research
- interferon and immune responses
- Adenosine and Purinergic Signaling
- Food Allergy and Anaphylaxis Research
- Eosinophilic Disorders and Syndromes
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Peroxisome Proliferator-Activated Receptors
University of Michigan
2015-2024
Michigan United
2022-2024
Michigan Medicine
2023
Instituto Politécnico Nacional
2013-2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2013-2015
Many studies have linked severe RSV infection during early-life with an enhanced likelihood of developing childhood asthma, showing a greater susceptibility in boys. Our show that leads to differential long-term effects based upon the sex neonate; leaving male mice prone exacerbation secondary allergen exposure while overall protecting female mice. During initial viral infection, we observed better control correlative expression interferon-β was not Additionally, persistent immune...
Early-life respiratory virus infections have been correlated with enhanced development of childhood asthma. In particular, significant numbers syncytial (RSV)-hospitalized infants go on to develop lung disease. It has suggested that early-life viral may lead altered or repair negatively impacts function later in life. Our data demonstrate RSV infection modifies structure, leading decreased function. At 5 wk postneonatal infection, defects are observed baseline pulmonary test (PFT) parameters...
Development of the immune system can be influenced by diverse extrinsic and intrinsic factors that influence risk disease. Severe early life respiratory syncytial virus (RSV) infection is associated with persistent alterations. Previously, our group had shown adult mice orally supplemented Lactobacillus johnsonii exhibited decreased airway immunopathology following RSV infection. Here, we demonstrate offspring L. exhibit reduced mucus Th2 cell–mediated response to Maternal supplementation...
In the present studies, assessment of how viral exacerbation asthmatic responses with and without pulmonary steroid treatment alters microbiome in conjunction immune presents striking data. The overall findings identify that although allergic animals diminished severity respiratory syncytial virus (RSV)-induced airway function mucus hypersecretion, there were local increases IL-17 expression. Analysis lung gut suggested are differences RSV further altered by fluticasone (FLUT) treatment....
Severe disease following respiratory syncytial virus (RSV) infection has been linked to enhanced proinflammatory cytokine production that promotes a Th2-type immune environment. Epigenetic regulation in cells viral plays role the inflammatory response and may result from upregulation of key epigenetic modifiers. In this study, we show RSV-infected bone marrow-derived dendritic (BMDC) as well pulmonary (DC) mice upregulated expression
Abstract Background Respiratory syncytial virus (RSV) affects most infants early in life and is associated with increased asthma risk. The specific mechanism remains unknown. Objective To investigate the role of uric acid (UA) IL‐1β RSV immunopathology predisposition. Methods Tracheal aspirates from human without were collected analyzed for pro‐IL‐1β mRNA protein to establish a correlation disease. Neonatal mouse models employed, wherein mice infected at 6‐7 days 8 postinfection, 5 weeks or...
Lactobacillus johnsonii is a commensal bacterium that has been isolated from vaginal and gastrointestinal (GI) tracts of vertebrate hosts, including humans, rodents, swine, poultry. -based probiotic supplements are popular because the health advantages they offer. Species such as L. particularly interesting due to their potential health-promoting properties. Here, we reviewed research on specific strains have studied in context disease delved into underlying mechanisms aid preserving host...
Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk developing asthma later in life. Previously, our group has shown that RSV infection mice and promotes IL-1β production. Here, we characterized the role NLRP3-Inflammasome activation during adult neonates. We observed inhibition NLRP3 using small molecule inhibitor, MCC950, or genetically modified knockout (Nlrp3−/−) vivo led decreased lung immunopathology along...
Our studies have previously shown a role for persistent TSLP production in the lungs of mice after early-life respiratory syncytial virus (RSV) infection that leads to an altered immune phenotype, including accumulation "inflammatory" dendritic cells (DC). This study investigates driving systemic trained immunity DC RSV-infected mice. Bone marrow-derived DCs (BMDC) from at 4 wk postinfection showed enhanced expression costimulatory molecules and cytokines, Tslp, regulate cell function. The...
Abstract Background Entamoeba histolytica is an intestinal protozoan parasite that causes amoebiasis in humans, affecting up to 50 million people worldwide each year and causing 40,000 100,000 deaths annually. EhCP112 a cysteine proteinase of E. able disrupt cell monolayers digest extracellular matrix proteins, it secreted by trophozoites can be active wide range temperature pH. These characteristics have encouraged the use design production possible vaccines against amoebiasis, obtaining...
Allergic asthma is a chronic airway inflammatory response to different triggers like inhaled allergens. Excessive ATP in fluids from patients with considered an signal and important autocrine/paracrine modulator of physiology. Here, we investigated the deleterious effect increased extracellular (eATP) concentration on mucociliary clearance (MCC) effectiveness determined role releasing channels during inflammation ovalbumin (OVA)-sensitized mouse model. Our allergic model exhibited high...
SUMMARY Entamoeba histolytica is the protozoan parasite causative of human amoebiasis, disease responsible for 40 000–100 000 deaths annually. The cysteine proteinase-adhesin complex this (EhCPADH) a heterodimeric protein formed by protease (EhCP112) and an adhesin (EhADH) that plays important role in cytopathic mechanism parasite. coding genes EhCP112 EhADH are adjacent E. genome, suggesting their expression may be co-regulated, but hypothesis has not yet been confirmed. Here, we performed...
Abstract The pathogenesis of asthma has been partially linked to lung and gut microbiome. We utilized a steroid‐resistant chronic model cockroach antigen‐induced (CRA) with corticosteroid (fluticasone) treatment examine microbiome during disease. pathophysiology assessment demonstrated that mucus airway hyperresponsiveness were increased in the CRA no alteration fluticasone (Flut)‐treated group, demonstrating steroid resistance. Analysis mRNA from lungs showed decrease MUC5AC or Gob5...
Eosinophilic esophagitis (EoE) is a T helper (Th)2-mediated inflammatory disorder characterized endoscopically by eosinophilic infiltration leading to fibrosis of the esophagus. Stem cell factor (SCF), multifunctional cytokine, upregulated in several allergic diseases, including patients with EoE. Mast cells and eosinophils express c-kit, surface receptor for SCF, have been found play an important role Therefore, we investigated whether blocking SCF represents potential therapeutic approach...
Food allergy is a growing public health problem with ~15 million people affected in the United States. In allergic food disease, IgE on mast cells bind to ingested antigens leading activation and degranulation of cells. Stem cell factor (SCF) growth that required for peripheral tissue We targeted specific isoform SCF, larger 248 amino acid form, drives differentiation using monoclonal antibody model allergy. Ovalbumin sensitized intragastrically challenged mice were monitored symptoms...
This study investigates sex-associated systemic innate immune differences by examining bone marrow-derived dendritic cells (BMDCs). BMDC grown from 7-day-old mice show enhanced type-I interferon (IFN) signaling in female compared to male BMDC. Upon respiratory syncytial virus (RSV) infection of mice, a significantly altered phenotype at 4 weeks post-infection is observed sex-dependent manner. The alterations include heightened Ifnb/ interleukin (Il12a) and IFNAR1+ expression early-life...