We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis.We obtained mucosal biopsies (N = 236) collected from terminal ileum ascending sigmoid colons (median age 13 years) IBD (43 Crohn's disease [CD], 23 ulcerative colitis [UC]), 30 without (controls). Patients were recruited managed at a hospital in the United Kingdom 2013 through 2016. also later...

Background: Living at home following a diagnosis of dementia can be difficult for both the person living with (PwD) and their family caregivers (FCG). Active group music participation may provide an avenue emotional release, offer psychosocial support to stimulate meaningful interaction between loved ones dementia. Therapeutic interventions also have capacity facilitate reminiscence social engagement help manage challenging symptoms associated dementia, such as anxiety, apathy, agitation....

Pharmacological interventions to address behavioural and psychological symptoms of dementia (BPSD) can have undesirable side effects, therefore non-pharmacological approaches managing may be preferable. Past studies show that music therapy reduce BPSD, other explored how formal caregivers use in their caring roles. However, no randomised study has examined the effects on BPSD delivered by informal (CGs) home setting. Our project aims need for improved care training cohabiting family CGs...

Abstract Social learning theory has been widely implemented to understand cyber deviance. Nevertheless, the antecedent scholarship homogenously nested in perspective of offending specification, leaving versatility thesis unattained. The lack such studies may undermine capability comprehensively understanding social patterns online offending. Using a sample 3741 Chinese college students, this study estimated an array binary logistic regressions compare effects traditional and four types...

This study aimed to test the feasibility of implementing a group songwriting program with family caregivers people living dementia. Fourteen consented participate in either (n=8) or control condition (n=6). Participants completed baseline and 7-week measures depression (PHQ-9), perceptions their caregiving experience (PACQ), relationship care recipient (QCPR). A six-session was implemented across two sites, focusing on participants co-creating song about experiences. Participation retention...

Psychosocial interventions for people with dementia and their family caregivers together may sustain relationship quality social connection. No previous music therapy research has examined the effects of group therapeutic songwriting (TSW) attended by dementia/family caregiver dyads.This pre-post feasibility study aimed to examine acceptability a TSW intervention dyads test sensitivity following outcomes: Quality Caregiver-Patient Relationship (QCPR, primary); Cornell Scale Depression in...

Background: The requirement for critical care in even a modest fraction of SARS-CoV-2 infected individuals made ICU resources an important societal chokepoint during the recent pandemic. We developed simple regression-based point score 2020 based on objective forecasting occupancy Canadian province Ontario mean age cases, case numbers, and testing volume. Evolution pandemic (variants concern, vaccination) led us to re-assess re-calibrate our earlier work, with inclusion information...

In the UK, over 20% of patients leaving hospital after a stroke will be severely disabled. Despite this, limited clinical guidance is available to teams tasked with providing support for this complex population at home. Additionally, many areas across UK are not commissioned treat patient cohort, them no specialist on discharge.

Abstract Malignant pleural mesothelioma (MPM) is a rare but lethal cancer with high intratumor heterogeneity (ITH). A recent study in lung adenocarcinoma has developed clonal gene signature (ORACLE) from multiregional transcriptomic data and demonstrated prognostic values reproducibility. However, such strategy not been tested other types of ITH. We aimed to identify biomarkers multi-regional prognostically stratify MPM patients. generated RNA-seq dataset for 78 tumor samples obtained 26...

The clinical differentiation of progressive supranuclear palsy from P arkinson's disease can be challenging, due to overlapping features and a lack diagnostic markers. Abnormalities in cognitive function form part the spectrums these diseases distinctive profiles may helpful differentiating period. A comprehensive neuropsychological test battery was administered 12 patients with clinically diagnosed matched for age duration. Effect size ( C ohen's d ) calculated tests that were significantly...

High-quality clinical trials testing music therapy interventions have become more prevalent over the past decade. However, recent reviews of published reveal that reporting strategies used to ensure treatment fidelity is lacking. Treatment refers methodological strategies, put in place prior trial implementation, strengthen reliability and validity intervention delivery and, therefore, safeguard research quality. This paper outlines developed implemented during pilot phase a randomized...

The wellbeing of people living with dementia and their family caregivers may be impacted by stigma, changing roles, limited access to meaningful opportunities as a dyad. Group therapeutic songwriting (TSW) qualitative interviews have been utilized in music therapy research promote the voices participating separate groups but not together dyads.This study aimed explore how ten dementia/family caregiver dyads experienced 6-week group TSW program. Dyads participated homogenous involving 2-4 who...

Neurological trauma is associated with significant damage to people's pre-injury self-concept. Therapeutic songwriting has been linked changes in self-concept and improved psychological well-being.This study analyzed the lyrics of songs composed by inpatients neurological injuries who participated a targeted program. The aim this was understand which subdomains were most frequently expressed songs.An independent, deductive content analysis 36 12 adults spinal cord injury or brain (11 males,...

Objective: To determine the size of effects and feasibility (recruitment retention rates) a therapeutic songwriting protocol for in-patients community-dwelling people with acquired brain injury or spinal cord injury. Design: Randomized controlled trial intervention care-as-usual control groups, in mixed measures design assessed at three time points. Participants: A total 47 participants (3 injury, 20 community 12 injury: 23 1208 days post injury). Interventions: The group received 12-session...

To examine direct cost to patients associated with oral oncolytics for the management of multiple myeloma (MM) both before and after financial assistance, assess effect on adherence.In this retrospective study, pharmacy claims were analyzed those a diagnosis MM who received thalidomide, lenalidomide, or pomalidomide from large specialty in US between January 1, 2011, December 31, 2013. Average patients, per prescription, was assistance. Adherence assessed through an analysis medication...

Play has well-established physical and mental benefits for people of all ages. Urban spaces, such as parks, provide important public arenas in which to play. But what extent do planners or planning scholarship focus on facilitating play? Our systematic literature review 3,800 articles nineteen academic journals returned 126 related We found that the play is an emerging discourse overwhelmingly focused children design urban spaces predominantly English-speaking nations. The study identifies...

The resources involved in delivering a clinical trial residential aged care facilities (RACFs) are significant and the success of is dependent upon adequate planning, including appropriate timelines for each component study required budget. This paper describes process resource assessment during recruitment, collection outcome measures intervention delivery, presents learnings considerations conducting trials RACFs with people living dementia.Data were collected across 24 clusters 12 over 18...

Acquired brain injury (ABI) presents a significant threat to sense of self and necessitates complex process psychosocial adjustment. Self-concept changes remain understudied in the early stages inpatient rehabilitation. The aim current study was examine self-concept, distress, wellbeing functional skills for five inpatients undertaking music therapy intervention within subacute rehabilitation centre Victoria, Australia. Participants completed six-week, 12-session therapeutic songwriting...

Abstract Background Despite growing support for the benefits of music interventions in dementia care, perspectives people with dementia, their families and carers are often missing from research. This study explored multiple first‐person experiences group delivered within a large cluster randomised controlled trial examining effectiveness therapy (GMT) recreational choir singing (RCS) living residential‐aged care (RAC) settings. Methods Focus individual interviews residents ( n = 4), family...

Abstract Objectives 1) To describe the demographic and clinical characteristics of residents with dementia depressive symptoms in Australian private residential aged care (RAC) context; 2) to investigate association between neuropsychiatric symptoms, depression quality life their interactions severity. Methods This study examined baseline data from arm Music Interventions for Dementia Depression ELderly (MIDDEL) study, a multinational, cluster‐randomised controlled trial. Demographic...

Recurrent painful ophthalmoplegic neuropathy (RPON), previously known as migraine, is a disorder typically characterized by recurrent episodes of unilateral headache concurrent with ipsilateral ocular cranial nerve paresis which primarily affects children. Diagnosis mostly one exclusion, based on clinical symptoms, supplemented imaging for enhanced or distorted oculomotor nerves. We present case RPON in 24-year-old adult female unique features left pupillary dilation spreading to bilateral...

Abstract We explored blockchain’s applications in nursing informatics, highlighting its potential to improve patient care and data management. compared analyzed eight studies focusing on blockchain Electronic Health Records (EHR) management, optimization, research facilitation. Although most of these are the proposal stage, technical features show promise enhancing practices supporting informatics researchers with integration technologies.