A5063672783- Diet and metabolism studies
- Gut microbiota and health
- Nutritional Studies and Diet
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Parasitic Diseases Research and Treatment
- Cardiac Health and Mental Health
- Helicobacter pylori-related gastroenterology studies
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Barrier Structure and Function Studies
- Blood Pressure and Hypertension Studies
- Mesenchymal stem cell research
- Gastroesophageal reflux and treatments
- Blood disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Health Promotion and Cardiovascular Prevention
- Nutrition, Genetics, and Disease
- Pluripotent Stem Cells Research
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
Monash University
2020-2024
Baker Heart and Diabetes Institute
2024
Ministry of Health
2019-2024
Institute for Medical Research
2019-2024
Monash Institute of Medical Research
2013
Recent evidence supports a role for the gut microbiota in hypertension, but whether ambulatory blood pressure is associated with and their metabolites remains unclear. We characterized function of microbiota, receptors untreated human hypertensive participants Australian metropolitan regional areas. Ambulatory pressure, fecal microbiome predicted from 16S rRNA gene sequencing, plasma called short-chain fatty acid, expression were analyzed 70 otherwise healthy communities. Most normotensives...
Abstract Aims Animal models are regularly used to test the role of gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes angiotensin II hypertensive model. However, is influenced by internal and external experimental factors, which not considered study design. Once these factors accounted for, it unclear if signatures reproduceable. We aimed determine influence treatment on using a large diverse cohort mice quantify magnitude other contribute variations....
BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to production metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain acids activate host signaling responses via functionally redundant receptors GPR41 GPR43, are highly expressed immune cells. Whether how these protect against hypertension or mediate effects remains unknown. METHODS: Cardiovascular phenotype was assessed in untreated Ang II (angiotensin II)...
Abstract Fermentation of dietary fibre by the gut microbiota leads to production metabolites called short-chain fatty acids (SCFAs), which have emerged as potent regulators immune, metabolic, and tissue barrier functions. More recently, a high diet SCFA supplementation were shown lower blood pressure be cardio-protective. SCFAs activate host signalling responses via receptors GPR41 GPR43, redundancy in their pathways. Whether these play role hypertension or mediate cardio-protective effects...
Gut microbiome research has increased dramatically in the last decade, including renal health and disease. The field is moving from experiments showing mere association to causation using both forward reverse approaches, leveraging tools such as germ-free animals, treatment with antibiotics, fecal microbiota transplantations. However, we are still seeing a gap between discovery translation that needs be addressed, so patients can benefit microbiome-based therapies. In this guideline paper,...
Abstract Primary immunodeficiency diseases refer to inborn errors of immunity (IEI) that affect the normal development and function immune system. The phenotypical genetic heterogeneity IEI have made their diagnosis challenging. Hence, whole-exome sequencing (WES) was employed in this pilot study identify etiology 30 pediatric patients clinically diagnosed with IEI. potential causative variants identified by WES were validated using Sanger sequencing. Genetic attained 46.7% (14 30)...
Abstract High blood pressure (BP) is the most common cause of death globally, due to increasing risk cardiovascular diseases. Dietary fiber regulates BP through gut microbial production acidic metabolites known as short-chain fatty acids (SCFAs). The specific mechanisms how SCFAs regulate are still emerging. In a phenome-wide association study, we identified that proton-sensing G-protein-coupled receptor GPR65 gene associated with hypertension and its end-organ damage phenotypes. We...
Abstract We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load post-stroke brain and functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate activation nervous system after stroke promotes gut-derived enter brain, this process worsens motor function mice. Figure
Background/Objective: Dietary fibre lowers blood pressure (BP) via short-chain fatty acids, acidic metabolites released from fermentation by the bacteria in large intestine. This microenvironment may activate pH-sensing receptor GPR68, expressed primarily on immune cells, which play a crucial role BP regulation. Here, we aimed to investigate whether GPR68 confers cardioprotective effects of high-fibre diet hypertension regulating inflammatory responses. Methods: 6–8-week-old male wildtype...
Background: Gut microbial metabolites called short-chain fatty acids (SCFA) confer protective effects against cardiovascular disease and high blood pressure. Proposed mechanisms include anti-inflammatory signalling mediated by SCFA-sensing G-protein-coupled receptors (GPCR), particularly GPR41, GPR43, GPR109a, as suggested knockout mouse models. We aimed to determine if rare pathogenic variants (RPVs) affecting GPCR genes in humans increase the risk of hypertension (HTN) major adverse...
Abstract Introduction Animal models are regularly used to test the role of gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes angiotensin II hypertensive model. However, is influenced by internal and external factors not considered study design. Once these accounted for, it unclear if signatures reproduceable. We aimed determine influence treatment on using a large diverse cohort mice quantify magnitude which other contribute variations. Methods...
Abstract Recent evidence supports a role for the gut microbiota in hypertension, but whether ambulatory blood pressure (BP) is associated with and their metabolites remains unclear. We characterised function of microbiota, receptors untreated human hypertensive participants Australian metropolitan regional areas. Ambulatory BP, faecal microbiome predicted from 16S rRNA gene sequencing, plasma called short-chain fatty acid (SCFAs), expression were analysed 70 otherwise healthy communities....
Objective: Dietary fibre lowers blood pressure (BP) and risk of cardiovascular disease death via production acidic metabolites by the gut microbiota. The mechanisms involved, however, are still elusive. Here, we aimed to understand role intestinal pH proton-sensing receptor GPR65 in protection dietary fibre. Design method: Intestinal C57BL/6 (WT) mice was measured after a 7-day intervention with different levels impact on an inflammatory cytokine, TNFa, determined flow cytometry. We also...
High dietary fibre is fermented by the gut microbiota, resulting in release of metabolites called short-chain fatty acids (SCFAs). Both and SCFAs can reduce high blood pressure (BP) its associated cardio-renal complications. However, underlying mechanisms remain unclear. be detected metabolite-sensing receptors GPR41 GPR43, highly expressed immune cells such as macrophages. We hypothesised that attenuates hypertension modulating renal macrophage infiltration via GPR43. To test this, we...