A5047508214- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Obesity, Physical Activity, Diet
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Bee Products Chemical Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
Tufts University
2016-2025
Jilin Agricultural University
2025
Second Hospital of Shandong University
2023-2024
Agricultural Research Service
2016-2023
Jean Mayer Human Nutrition Research Center on Aging
2013-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Interface (United Kingdom)
2020
University of East Asia
2020
John Wiley & Sons (United States)
2020
United States Department of Agriculture
2008-2019
Abstract The Para rubber tree ( Hevea brasiliensis ) is an economically important tropical species that produces natural rubber, essential industrial raw material. Here we present a high-quality genome assembly of this (1.37 Gb, scaffold N50 = 1.28 Mb) covers 93.8% the (1.47 Gb) and harbours 43,792 predicted protein-coding genes. A striking expansion REF/SRPP (rubber elongation factor/small particle protein) gene family its divergence into several laticifer-specific isoforms seem crucial for...
Using the genome-wide association approach, we recently identified glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, sought to study of GCKR variants with metabolic phenotypes, including measures glucose homeostasis, evaluate samples non-European ancestry and fine- map across associated genomic interval.We performed studies 12 independent cohorts comprising >45,000 individuals representing...
Abstract In one of the longest-running experiments in biology, researchers at University Illinois have selected for altered composition maize kernel since 1896. Here we use an association study to infer genetic basis dramatic changes that occurred response selection oil concentration. The population was produced by a cross between high- and low-selection lines generation 70, followed 10 generations random mating derivation 500 selfing. These were genotyped 488 markers concentration evaluated...
Introduction. Previous studies identified genetic links between the TCF7L2 C/T variant rs7903146, type 2 diabetes (T2D), and obesity. We wished to deepen our understanding of how specific diets interact with this affect blood metabolites, an aspect not previously investigated. Hence, we conducted a controlled study where individuals different genotypes followed Mediterranean (Med) or low-fat (LF) diet for one week. Methods. Participants were recruited from Boston, MA (USA) area....
Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between and lipoprotein subclasses, remnant-like particles (RLPs), cardiovascular disease (CVD) risk less explored. We investigated of five single-nucleotide (SNPs; -1131T>C, -3A>G, 56C>G IVS3+ 476G>A, 1259T>C) subfractions CVD 1,129 men 1,262 women participating Framingham Heart Study. Except for SNP, other SNPs were significant linkage disequilibria,...
The association between quantitative genetic variation in bristle number and molecular at a candidate neurogenic locus, scabrous, was examined Drosophila melanogaster. Approximately 32 percent of the abdominal (21 for sternopleural number) among 47 second chromosomes from natural population correlated with DNA sequence polymorphisms this locus. Several polymorphic sites associated large phenotypic effects occurred intermediate frequency. Quantitative populations caused by alleles that have...
Singapore comprises three ethnic groups: Chinese (76.7%), Malays (14%), and Asian-Indians (7.9%). Overall, Singaporeans experience coronary heart disease rates similar to those found in the United States. However, there is a dramatic interethnic gradient, with having significantly higher risk than Malays. These differences are associated HDL cholesterol levels cannot be solely explained by environmental exposure, may driven genetic factors. The gene encoding apolipoprotein A-V (APOA5) has...
Abstract Background: Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis. Methods: We studied the association between a functional APOA2 promoter polymorphism (−265T>C) plasma lipids (fasting postprandial), anthropometric variables, food intake 514 men 564 women who participated Genetics of Lipid Lowering Drugs Diet Network (GOLDN) study. obtained fasting postprandial (after consuming high-fat meal) measures. measured lipoprotein...
Background— Apolipoprotein A5 gene ( APOA5 ) variation is associated with plasma triglycerides (TGs). However, little known about whether dietary fat modulates this association. Methods and Results— We investigated the interaction between in determining fasting TGs, remnant-like particle (RLP) concentrations, lipoprotein size 1001 men 1147 women who were Framingham Heart Study participants. Polymorphisms −1131T>C 56C>G, representing 2 independent haplotypes, analyzed. Significant...
Objective— Apolipoprotein A5 ( APOA5 ) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the locus could be responsible for some observed differences in response to fenofibrate therapy. Methods and Results— We examined association between tag SNPs (−1131T>C 56C>G) TG HDL-C postprandial lipid challenge 791 men women participating GOLDN study. After 3-week drug treatment, 56G carriers displayed significant decrease P =0.006), increase =0.002) levels...
Drosophila melanogaster has been considered a model organism for investigating human diseases and genetic pathways. Whether is an ideal nutrigenomics, especially FA metabolism, however, remains to be illustrated. The aim of this study was examine the metabolism C20 C22 PUFAs in Drosophila. Analysis composition revealed complete lack body tissue larvae, pupae, adult flies fed either base or supplemented diet abundant PUFA precursors linoleic acid α-linolenic acid. with >C20 could only found...
Gene variants within regulatory regions are thought to be major contributors of the variation complex traits/diseases. Genome wide association studies (GWAS), have identified scores genetic that appear contribute human disease risk. However, most these do not functional. Thus, significance may brought up by still unknown mechanisms or linkage disequilibrium (LD) with functional polymorphisms. In present study, focused on related binding microRNAs (miR), we utilized SNP data, including newly...