A5054719835- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic Syndromes and Imprinting
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Neurodevelopmental Disorders
- Cognitive Abilities and Testing
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Sleep and related disorders
- Homelessness and Social Issues
- Child Nutrition and Feeding Issues
- Sleep and Wakefulness Research
- Crime Patterns and Interventions
- Circadian rhythm and melatonin
- Health, Environment, Cognitive Aging
- Fetal and Pediatric Neurological Disorders
- Biomedical Ethics and Regulation
- Biotechnology and Related Fields
- Mental Health Research Topics
- Ferroptosis and cancer prognosis
- Fault Detection and Control Systems
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
Vrije Universiteit Amsterdam
2017-2024
Amsterdam Neuroscience
2017-2024
Amsterdam University Medical Centers
2019-2020
Genome-wide association studies (GWAS) of psychological traits are generally conducted on (dichotomized) sums items or symptoms (e.g., case-control status), and not the individual themselves. We conduct large-scale GWAS 12 neuroticism observe notable replicable variation in genetic signal between items. Within samples, correlations among range 0.38 0.91 (mean r
Neuroticism is an important risk factor for psychiatric traits including depression 1 , anxiety 2,3 and schizophrenia 4–6 . Previous genome-wide association studies 7–12 (GWAS) reported 16 genomic loci 10–12 Here we report the largest neuroticism GWAS meta-analysis to date (N=449,484), identify 136 independent significant (124 novel), implicating 599 genes. Extensive functional follow-up analyses show enrichment in several brain regions involvement of specific cell-types, dopaminergic...
Abstract Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC heritable and partially translates to the anatomic architecture of white matter, but genetic component structural connections RSNs (RSN-SC) their potential overlap with remain unknown. Here, we perform genome-wide association studies ( N discovery = 24,336; replication 3412) annotation on RSN-SC RSN-FC. We identify genes visual network-SC that are involved in axon guidance...
Abstract Insomnia is the second-most prevalent mental disorder, with no sufficient treatment available. Despite a substantial role of genetic factors, only handful genes have been implicated and insight into associated neurobiological pathways remains limited. Here, we use an unprecedented large association sample (N=1,331,010) to allow detection number variants gain biological functions, cell types tissues involved in insomnia complaints. We identify 202 genome-wide significant loci...
Abstract Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better understanding of modalities could inform us on the integration function, micro- and macrostructure. Here we show extensive genetic overlap at a locus gene level in UK Biobank ( N = 34,029) ABCD Study 8607). When jointly analysing phenotypes MRI genome-wide association study...
Abstract Cerebellar volume is highly heritable and associated with neurodevelopmental neurodegenerative disorders. Understanding the genetic architecture of cerebellar may improve our insight into these This study aims to investigate convergence associations in close detail. A genome-wide for was performed a discovery sample 27,486 individuals from UK Biobank, resulting 30 significant loci SNP heritability 39.82%. We pinpoint likely causal variants those that have effects on amino acid...
Intelligence is highly heritable 1 and a major determinant of human health well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to intelligence 3–7 , but much about its genetic underpinnings remains be discovered. Here, we present the largest association study date (N=279,930), identifying 206 (191 novel) implicating 1,041 genes (963 via positional mapping, expression quantitative trait locus (eQTL) chromatin interaction gene-based analysis. We find...
Abstract The phenotypic correlation between human intelligence and brain volume (BV) is considerable ( r ≈0.40), has been shown to be due shared genetic factors 1 . To further examine specific driving this correlation, we present genomic analyses of the overlap BV using genome-wide association study (GWAS) results. First, conducted largest GWAS meta-analysis date (N=54,407 individuals), followed by functional annotation gene-mapping. We identified 35 loci (27 novel), implicating 362 genes...
The widespread comorbidity among psychiatric disorders (PDs) demonstrated in epidemiological studies 1–5 is mirrored by non-zero, positive genetic correlations from large scale 6–10 . We employed several strategies to uncover pleiotropic SNPs, genes and biological pathways 7,8 underlying this covariance. First, we conducted cross-trait meta-analysis on 12 PDs identify SNPs. However, the majority of meta-analytic signal was driven only one or a few PDs, hampering interpretation joint...
Abstract The functional connectivity and dynamics of resting-state networks (RSN-FC) are vital for cognitive functioning. RSN-FC is heritable partially translates to the anatomical architecture white matter, but genetic component structural connections RSNs (RSN-SC) their potential overlap with remains unknown. Here we perform genome-wide association studies (N discovery =24,336; N replication =3,412) in silico annotation on RSN-SC RSN-FC. We identify first genes visual network-SC, that...
Mental health problems are highly prevalent in modern-day society. Despite several decades of intensive research aimed at identifying the underlying biological mechanisms, and potential drug targets, pharmacological treatments still have limited success. Since all traits least partially influenced by our genetic makeup, using information to increase understanding mechanisms mental might eventually benefit patients. Genome-wide association studies (GWAS) provide an exploratory way identify...
Abstract Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion MRI). A better understanding of modalities could inform us on the integration function, micro- and macrostructure. Here we show extensive genetic overlap at a locus gene level in UK Biobank (N=34,029) ABCD Study (N=8,607). When jointly analysing phenotypes MRI with Multivariate Omnibus Statistical Test (MOSTest), boost...