A5080371251- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Reliability and Agreement in Measurement
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics, Aging, and Longevity in Model Organisms
- Hemodynamic Monitoring and Therapy
- Systemic Lupus Erythematosus Research
- Cerebrospinal fluid and hydrocephalus
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- DNA Repair Mechanisms
- Meta-analysis and systematic reviews
- Genetic Syndromes and Imprinting
- Advanced Text Analysis Techniques
- Sex and Gender in Healthcare
University of Southern Denmark
2016-2025
Odense University Hospital
2015-2019
Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective this study to investigate effect selenium supplementation different doses on function, under conditions suboptimal dietary intake.The Danish PREvention Cancer by Intervention with SElenium pilot (DK-PRECISE) a randomized, double-blinded, placebo-controlled trial. A total 491 males females aged 60-74 years were randomized 100 μg (n=124), 200 (n=122), or 300 (n=119)...
Placement of a subdural drain reduces recurrence and death after evacuation chronic hematoma (CSDH), but little is known about optimal drainage duration. In the present national trial, authors investigated effect duration on death.
Long-term outcome in multiple sclerosis (MS) depends on early treatment. In patients with acute optic neuritis (ON), an inflammatory event, we investigated markers cerebrospinal fluid (CSF), which may predict a diagnosis of MS. Forty ON were recruited prospective population-based cohort median 29 months (range 19–41) follow-up. Paired CSF and serum samples taken within 14 days 2–38), prior to Prospectively, 16/40 by uniform algorithm diagnosed MS (MS-ON) 24 continued manifest isolated (ION)...
Manual assessment of muscle strength is often graded using the ordinal Medical Research Council (MRC) scale. The scale has a number inherent weaknesses, including poorly defined limits between grades '4' and '5' very large differences in span encompassed by each six grades. It not necessarily obvious how to convert manual test finding into an MRC grade. Several modifications which include intermediate have been suggested improve current study examines whether agreement improves variation...
Several studies have linked DNA methylation at individual CpG sites to aging and various diseases. Recent also identified single CpGs whose levels are associated with all-cause mortality. In this study, we perform an epigenome-wide study of the association between mortality in a population 435 monozygotic twin pairs from three Danish studies. The participants were aged 55–90 time blood sampling followed for up 20 years. We validated our results by comparison British Swedish cohort, as well...
A new Danish school policy with a requirement for 45 min physical activity daily during hours was introduced in 2014. The objective of this natural experiment to evaluate the effect nationwide on children and adolescents.Four historical studies completed between 2009 2012 comprised pre-policy study population. Post-policy data were collected 2017/18. All post-policy schools represented four studies. Age-groups seasons matched. In total, 4816 adolescents aged 6-17 included analyses (2346 2470...
OBJECTIVE Intraventricular hemorrhage (IVH) is a serious condition with high mortality rates and poor functional outcome in survivors. Treatment includes external ventricular drains (EVDs), which are associated several complications. This study reports the clinical complication rate patients primary IVH (pIVH) secondary treated EVDs. METHODS The authors conducted retrospective observational using Danish National Patient Registry. Patients EVDs for pIVH or between September 2012 August 2022...
This study investigates outcomes in patients undergoing surgery for chronic subdural hematoma comparing those receiving vs not antithrombotic therapy.
Competitive gene set analysis intends to assess whether a specific of genes is more associated with trait than the remaining genes. However, statistical models assumed date underly these methods do not enable clear cut formulation competitive null hypothesis. This major handicap interpretation results obtained from analysis.This work presents hierarchical model based on notion dependence measures, which overcomes this problem. The two levels naturally reflect modular structure many methods....
Objective: To investigate clinical outcomes in a real-world setting the complete population-based cohort of alemtuzumab-treated MS patients Denmark. Methods: Data were retrieved from The Danish Multiple Sclerosis Registry between 2009 and 2019. Demographic disease-specific patient parameters related to treatment history, efficacy, safety assessed at baseline during follow-up visits. Results: A total 209 (78% female) started with alemtuzumab study period 3.1 ± 1.4 years follow-up. After 2...
Copy number variants (CNVs) represent a significant source of genetic variation in the human genome and have been implicated numerous diseases complex traits. To date, only few studies investigated role CNVs lifespan. investigate impact on prospective mortality at extreme end life, where component lifespan appears most profound, we analyzed genomewide CNV data 603 Danish nonagenarians centenarians (mean age 96.9 years, range 90.0–102.5 years). Replication was performed 500 long-lived...
Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but respect to prevention, the ability predict onset MOH is clinically important. The aims were examine if personality characteristics, disability and physical activity level a group explore which extend these factors combined can MOH.The study was single-center prospective observational patients. At inclusion, all completed questionnaires evaluating 1) (NEO Five-Factor...
The Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed in 2011 to support transparent accurate reporting. These studies may be conducted with the primary aim of estimating reliability and/or agreement itself, but are more often than not part larger diagnostic accuracy studies, clinical trials, or epidemiological studies. As such, study design compromised terms practicability issues, preventing collection sufficient results. We presented an example from a...
Intelligence is highly heritable 1 and a major determinant of human health well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to intelligence 3–7 , but much about its genetic underpinnings remains be discovered. Here, we present the largest association study date (N=279,930), identifying 206 (191 novel) implicating 1,041 genes (963 via positional mapping, expression quantitative trait locus (eQTL) chromatin interaction gene-based analysis. We find...
Hand grip strength is a measure of muscular and used to study age-related loss physical capacity. In order explore the biological mechanisms that influence hand variation, an epigenome-wide association (EWAS) in 672 middle-aged elderly monozygotic twins (age 55–90 years) was performed, using both individual twin pair level analyses, latter controlling genetic variation. Moreover, as measurements performed over 8 years were available 73–90 at intake), longitudinal EWAS conducted for this...