A5080304993- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Multiple Sclerosis Research Studies
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nitric Oxide and Endothelin Effects
- Platelet Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Dermatological and COVID-19 studies
- Connective tissue disorders research
- Atrial Fibrillation Management and Outcomes
- Animal Virus Infections Studies
University of Pecs
2016-2025
Hinchingbrooke Health Care NHS Trust
2021
Uzsoki Hospital
2021
University Teaching Hospital
2021
University of Szeged
2013
Background Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between CNS autoimmunity. Methods gliadin, tissue transglutaminase (t TG ), intrinsic factor ( IF parietal cells PC ) S accharomyces cerevisiae ASCA were screened sera of 45 patients with AQP 4‐seropositive neuromyelitis optica NMO spectrum diseases / ‐ SD 17 4‐seronegative , 85 clinically definite multiple sclerosis MS 48...
Objective Here, we applied a multi-omics approach (i) to examine molecular pathways related de- and remyelination in multiple sclerosis (MS) lesions; (ii) translate these findings the CSF proteome order identify molecules that are differentially expressed among MS subtypes. Methods To relate genes lesions remyelination, compared transcriptome of cuprizone (CPZ)-induced remyelination. Protein products overlapping orthologous were measured within by quantitative proteomics, parallel reaction...
Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline severity of fatigue anti-SARS-CoV-2 antibodies. Methods: were assessed in a total 101 subjects using Chalder scale (CFQ-11) visual analogue scale. Using bimodal scoring system generated CFQ-11, score ≥4 was severe fatigue. Serum spike (anti-S-Ig)...
A number of data indicate that the lectin pathway complement activation contributes to pathophysiology ischemic stroke. The may be triggered by binding mannose-binding (MBL), ficolin-2 or ficolin-3 different ligands. Although several papers demonstrated significance MBL in stroke, role ficolins has not been examined. Sera were obtained within 12 hours after onset stroke (admission samples) and 3-4 days later (follow-up from 65 patients. control group comprised 100 healthy individuals 135...
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause mortality. Clinical criteria AECOPD are subjective. Biomarkers for may aid in the initiation early treatment. Increased production asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, rise ADMA results shift L-arginine breakdown, contributing airway obstruction. We aimed compare serum levels ADMA, SDMA patients with without AECOPD.
The effect of post-vaccination adverse events on immunogenicity is unknown. We aimed to explore relationship between reactions and antibody levels during 6-month follow-up.Blood was serially drawn from healthcare workers after the second dose BNT162b2 mRNA vaccine (Day 12, 30, 60, 90, 120, 150, 180) anti-SARS-CoV-2 spike IgG (S-IgG) were measured. Following each dose, volunteers completed a questionnaire regarding (symptomatic vs. asymptomatic groups).A total 395 subjects received vaccine....
Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition complicated by delayed cerebral ischemia (DCI), where inflammation plays key role. Although altered gut permeability noted in other conditions, its significance aSAH remains unclear. Fatty acid-binding protein (FABP-I), lipopolysaccharide-binding (LBP), and soluble CD-14 (sCD-14) are established markers of barrier dysfunction. This study investigates marker changes early late phases. The included 177 patients 100 controls....
Background: Subarachnoid hemorrhage is a serious condition caused by ruptured intracranial aneurysms, resulting in severe disability mainly young adults. Cerebral vasospasm one of the most common complication subarachnoid hemorrhage; thus, active prevention key to improve prognosis. The glycosylation proteins critical quality attribute which reportedly altered patients diagnosed with acute ischemic stroke. In this study, we examined N-glycosylation profile serum glycoproteins without...
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a disease associated with high mortality, caused by the rupture of cerebral aneurysm. Decision-support scoring systems used for managing unruptured aneurysms (UIAs) include only radiological parameters related to size and configuration aneurysm, without incorporating blood-based markers. Our aim identify serum marker that shows correlation aneurysm in patients ruptured aneurysms. Methods: Arterial blood samples were collected from who...
<i>Background:</i> Functional alterations of innate lymphocytes, which can mount rapid immune responses and shape subsequent T cell reactions, were examined in the acute phase ischemic stroke. <i>Methods:</i> Frequencies, intracellular perforin interferon-γ (IFN-γ) expression Vδ2 cells, CD3+ CD56+ natural killer (NKT)-like NK cells peripheral blood 20 healthy controls 28 patients within 6 h onset stroke after 72 by flow cytometry. Cytokine production isolated NKT-like...
Background/Aim Migraine is a risk factor for the formation of silent brain white matter lesions (WMLs) that are possibly ischemic in nature. Although dysfunction L-arginine/nitric oxide (NO) pathway has been associated with oxidative stress and endothelial migraine, its role WML development not specifically investigated. Thus, this prospective study aimed to measure serum concentrations NO substrate L-arginine, synthase inhibitor asymmetric dimethylarginine (ADMA), L-arginine transport...
We compared cost-effectiveness of anesthesia maintained with sevoflurane or propofol and without additional monitoring, in the clinical setting ear-nose-throat surgery. One hundred twenty adult patients were randomized to four groups. In groups SEVO SEVO+ was sevoflurane, group bispectral index (BIS) train-of-four (TOF) monitoring. PROP PROP+ propofol, BIS TOF Total cost per hour greater [€ 19.95(8.53) vs. 12.15(5.32), p < 0.001], (€ 22.11(8.08) 13.23(4.23), 0.001]. Time extubation shorter...
Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested role an unsatisfactory immune response and impaired viral clearance in pathogenesis long syndrome. We focused on potential associations between post-vaccination changes antibody titers severity symptoms factors influencing state remission observed patients with vaccination.The serum anti-SARS-CoV-2 spike (S-Ig) nucleocapsid (NC-Ig)...
Background: Neuromyelitis optica (NMO)–systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies. Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part polyclonal B cell activation, and if T contribute. Methods: In 19 samples six patients who developed NMO SLE, we examined correlation AQP4-IgG1 IgM with (i) anti-MOG IgG IgM, (ii) anti-nuclear, anti-nucleosome anti-dsDNA antibodies, (iii) cytokines chemokines in...
Growth differentiation factor 15 (GDF-15), neutrophil gelatinase-associated lipocalin (NGAL), and ADAMTS13 have previously been implicated in the pathophysiological processes of SAH. In present study, we aim to examine their role early period SAH relationship primary secondary outcomes. Serum samples were collected at five time periods after (at 24 h (D1), 72 (D3), 120 (D5), 168 (D7) 216 (D9), post-admission) and) measured by using MILLIPLEX Map Human Cardiovascular Disease (CVD) Magnetic...
The purpose of this study was to determine the relationship between high-sensitive C-reactive protein (hsCRP) and leukocyte antisedimentation rate (LAR) as a specific test detect early activation leukocytes providing first line defence
Objectives Teriflunomide 14 mg is a once-daily oral disease-modifying treatment for relapsing-remitting multiple sclerosis. We examined adverse event (AE) profile and efficacy in real life. Materials methods In this observational cohort study, we retrospectively 1521 blood samples data of 102 patients followed up to 28 months. Results The number female starting teriflunomide peaked the fifth decade, 10 years later compared male (P<.001), reflecting pregnancy concerns. Seventy-six percentages...
The prognosis for patients with aneurysmal subarachnoid hemorrhage (aSAH) is heavily influenced by the development of delayed cerebral ischemia (DCI), but adequate and effective therapy DCI to this day has not been resolved. Multiplex serum biomarker studies may help understand pathophysiological processes underlying DCI. Samples were collected from aSAH at two time points: (1) 24 h (Day 1) (2) 5−7 days after ictus. Serum concentrations eotaxin, FGF-2, FLT-3L, CX3CL1, Il-1b, IL-4, IP-10,...