A5074904985- Acute Ischemic Stroke Management
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Exercise and Physiological Responses
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Sports Performance and Training
- Cancer, Hypoxia, and Metabolism
- Migraine and Headache Studies
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and exercise physiology
- Glaucoma and retinal disorders
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Bone health and osteoporosis research
- Cardiovascular Effects of Exercise
- Restless Legs Syndrome Research
- Trigeminal Neuralgia and Treatments
- Transcranial Magnetic Stimulation Studies
University of Pecs
2014-2025
Population Health Research Institute
2024
McMaster University
2024
Hungarian University of Sports Science
2015-2022
Wayne State University
2015-2019
Children's Hospital of Michigan
2015-2019
Detroit Medical Center
2018
Universität Ulm
2017-2018
The Barbara Ann Karmanos Cancer Institute
2015-2017
Semmelweis University
2010-2014
A sexual dimorphism has been reported for the adipo-myokine irisin at rest and in response to exercise. The effects of male female sex, adiposity, gonadectomy on secretion have not investigated before. objective this study was elucidate regulation as well PGC-1α/FNDC5 mRNA protein expression. We hypothesized that a lack sex hormones by ovariectomy reduces levels inhibits skeletal muscle expression PGC-1α FNDC5. Circulating measured vivo serum samples healthy obese men women acute irisin,...
To elucidate cell free DNA (cfDNA) clearance kinetics following an acute bout of high intensity exercise by measuring circulating DNase activity reduction (AR). Serum cfDNA concentration and DNase-AR were measured prior to post (immediately post, 7 30 min post) rowing until exhaustion. was significantly (P ≤ .001) elevated immediately (2.5-fold) (2.3-fold) with a return close baseline at (1.5-fold). The rise in accompanied concomitant, significant decrease serum from 15.1% 3.1% AR cessation...
Abstract There is a growing interest in exploring irisin response to acute exercise; however, the associations of exercise‐induced release with training status and exercise mode are not fully understood. This study was primarily designed evaluate these associations. Sixteen healthy adults (8 trained versus 8 untrained) underwent bout cycling at 80% maximal oxygen uptake (VO 2max ) for 50 min, blood drawn pre‐, 10‐, 180‐min post‐exercise. Another 17 performed 2 bouts graded (cycling running)...
Although glioblastomas are heterogeneous brain-infiltrating tumors, their treatment is mostly focused on the contrast-enhancing tumor mass. In this study, we combined conventional MRI, diffusion-weighted imaging (DWI), and amino acid PET to explore imaging-defined glioblastoma subregions evaluate potential prognostic value. Contrast-enhanced T1, T2/fluid attenuated inversion recovery (FLAIR) MR images, apparent diffusion coefficient (ADC) maps from DWI, alpha-[11C]-methyl-L-tryptophan...
Increased tryptophan metabolism via the kynurenine pathway (KP) is a key mechanism of tumoral immune suppression in gliomas. However, details meningiomas have not been elucidated. In this study, we evaluated vivo and compared it with gliomas using α-[(11)C]-methyl-L-tryptophan (AMT)-PET. We also explored expression patterns KP enzymes resected meningiomas.Forty-seven patients MRI-detected meningioma (n = 16) glioma 31) underwent presurgical AMT-PET scanning. Tumoral AMT uptake tracer kinetic...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Guilherme JL, Bosnyák E, Semenova EA, et al. The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake. Biology of Sport. 2021;38(3):465-474. doi:10.5114/biolsport.2021.101638. APA Guilherme, J. L., Bosnyák, E., Semenova, E. A., Szmodis, M., Griff, & Móra, Á. (2021). Sport, 38(3), 465-474....
Background: Sleep problems are among the most common non-motor symptoms of Parkinson's disease (PD).The PD Scale 2nd version (PDSS-2) improved original PDSS by adding more items on different aspects sleep problems, making it a robust tool to evaluate severity disturbances.However, previous studies deep brain stimulation (DBS) have not used PDSS-2.Objective: To determine if PDSS-2 could detect improvement reliably in after bilateral subthalamic nucleus DBS for PD.Methods: In this prospective...
It was previously reported that diabetes mellitus (DM) and admission hyperglycemia (aHG) were associated with poor clinical outcomes in patients acute ischemic stroke (AIS) who treated intravenous thrombolysis (IVT) or mechanical thrombectomy (MT). Our study aimed to assess the prognostic effect of DM aHG (≥7.8 mmol/L) on recanalization therapies (IVT MT). multicentric based data from prospective STAY ALIVE registry between November 2017 January 2020. We compared demographic data, parameters...
Background/Objectives: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Despite advances in interventions such as thrombolysis (TL) mechanical thrombectomy (MT), current treatment protocols remain largely standardized, focusing on general eligibility rather than individual patient characteristics. To address this gap, we introduce the Stroke-SCORE (Simplified Clinical Outcome Risk Evaluation), predictive tool designed to personalize AIS management by...
Background/Objectives: Cryptogenic stroke, a challenging subtype of acute ischemic stroke (AIS), is characterized by the absence an identifiable etiology despite thorough diagnostic assessment. The role pre-admission antiplatelet therapy (APT) in this population remains poorly understood, as current guidelines are primarily based on evidence from other subtypes. Therefore, study investigates impact APT functional outcomes pa-tients with cryptogenic stroke. Methods: A total 224 patients...
Background/Objectives: Embolic Stroke of Undetermined Source (ESUS) is a subtype ischemic stroke characterized by non-lacunar infarct in the absence clearly identifiable embolic source, despite comprehensive diagnostic evaluation. While ESUS patients are typically younger, have fewer cardiovascular comorbidities, and experience milder strokes than those with cardioembolic (CE), their long-term functional recovery remains underexplored. Methods: We retrospectively analyzed data from 317 (n =...
Background/Objectives: Oral anticoagulants (OACs) are commonly used for stroke prevention in patients with atrial fibrillation (AF), but their impact on long-term outcomes following acute ischemic (AIS) remains uncertain. This study evaluated whether prior anticoagulation influences functional and mortality AIS patients. Methods: A total of 914 admitted to the Department Neurology, University Pécs, an from January 2023 September 2024, were retrospectively reviewed. Patients categorized into...
Background: Cryptogenic stroke, a challenging subtype of acute ischemic stroke (AIS), is characterized by the absence an identifiable etiology despite thorough diagnostic assessment. The role pre-admission antiplatelet therapy (APT) in this population remains poorly understood, as current guidelines are primarily based on evidence from other subtypes. Therefore, study investigates impact APT functional outcomes patients with cryptogenic stroke. Methods: A total 224 admitted to University...
Background/Objectives: An embolic stroke of undetermined source (ESUS) is a subtype ischemic characterized by non-lacunar infarct in the absence clearly identifiable source, despite comprehensive diagnostic evaluation. While ESUS patients are typically younger, have fewer cardiovascular comorbidities, and experience milder strokes than those with cardioembolic (CEs), their functional recovery remains underexplored. Methods: We retrospectively analyzed data from 374 (n = 94 ESUS, n 280 CE)...
<title>Abstract</title> <bold>Background:</bold> The management of acute ischemic stroke (AIS) in anticoagulated patients presents a clinical challenge, as concerns about safety and efficacy often limit access to recanalization therapies. Despite the widespread use direct oral anticoagulants (DOACs) vitamin K antagonists (VKAs), their impact on functional recovery mortality following intravenous thrombolysis (IVT) mechanical thrombectomy (MT) remains uncertain. Therefore, this study...
<title>Abstract</title> Background Direct oral anticoagulants (DOACs) are now the guideline-recommended alternative to vitamin K antagonists (VKAs) for long-term anticoagulation. However, accurately assessing their impact on ischemic stroke outcomes remains challenging, primarily due uncertainty regarding anticoagulation status at time of hospital admission. This study addresses that gap by using point-of-care testing (POCT) confirm DOAC activity bedside, allowing a more accurate comparison...
Asymmetry is one of the unique and mysterious features Parkinson's disease (PD). Motor symptoms develop unilaterally either on left (LPD) or right side (RPD). Incongruent data are available whether onset has an impact cognition in PD. The objective this study to compare visuospatial performance RPD LPD patients. Seventy-one non-demented, non-depressive right-handed patients were categorized into RBD (n = 36) 35) groups. Rey-Osterrieth Complex Figure Test (ROCF) was evaluated by both Taylor's...
Several molecular glioma markers (including isocitrate dehydrogenase 1 [IDH1] mutation, amplification of the epidermal growth factor receptor [EGFR], and methylation O6-methylguanine-DNA methyltransferase [MGMT] promoter) have been associated with glioblastoma survival. In this study, we examined association between tumoral amino acid uptake, markers, overall survival in patients IDH1 wild-type (primary) glioblastoma.Twenty-one newly diagnosed glioblastomas underwent presurgical MRI PET...
Background/Aim Migraine is a risk factor for the formation of silent brain white matter lesions (WMLs) that are possibly ischemic in nature. Although dysfunction L-arginine/nitric oxide (NO) pathway has been associated with oxidative stress and endothelial migraine, its role WML development not specifically investigated. Thus, this prospective study aimed to measure serum concentrations NO substrate L-arginine, synthase inhibitor asymmetric dimethylarginine (ADMA), L-arginine transport...
Background Sudden cardiac death in competitive athletes is rare but it significantly more frequent than the normal population. The exact cause seldom established and mostly attributed to ventricular fibrillation. Myocardial hypertrophy slow heart rate, both characteristic changes top response physical conditioning, could be associated with increased propensity for arrhythmias. We investigated conventional ECG parameters temporal short-term beat-to-beat variability of repolarization (STVQT),...