A5067638486- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Biotin and Related Studies
- Click Chemistry and Applications
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Posttraumatic Stress Disorder Research
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Vitamin D Research Studies
- Asthma and respiratory diseases
- Peroxisome Proliferator-Activated Receptors
- Resilience and Mental Health
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Cancer-related molecular mechanisms research
- Alcoholism and Thiamine Deficiency
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Myasthenia Gravis and Thymoma
- Olfactory and Sensory Function Studies
- Nuclear Receptors and Signaling
Yale University
2014-2020
VA Connecticut Healthcare System
2014-2020
Malden Public Schools
2015
Hudson Institute
2015
John Wiley & Sons (United States)
2015
Connecticut Health Foundation
2014
UConn Health
2007-2010
University of Connecticut
2002-2008
Henry Ford Hospital
2007
Hacettepe University
2007
Posttraumatic stress disorder (PTSD) is a prevalent, serious public health concern, particularly in the military. The identification of genetic risk factors for PTSD may provide important insights into biological foundation vulnerability and comorbidity.To discover loci associated with lifetime 2 cohorts from Army Study to Assess Risk Resilience Servicemembers (Army STARRS).Two coordinated genome-wide association studies mental US military contributed participants. New Soldier (NSS) included...
The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. Because microRNAs (miRNAs) have major roles in regulating gene expression, we speculated that they participate directing highly regulated spatiotemporally expressed genetic network during implantation. Here, show two miRNAs, mmu-miR-101a mmu-miR-199a*, are mouse uterus coincident with expression of cyclooxygenase-2, a critical for More interestingly, our...
We examined associations between haplotypes of the serotonin 1B receptor gene and individual differences in anger hostility. Data were analyzed from a study 361 university students (47% male). Participants genotyped at five polymorphisms HTR1B (rs11568817, rs130058, rs6296, rs6297, rs13212041), including promoter 3'UTR with opposite functional effects on expression. reported their emotional states across 30 consecutive days for up to 4 years. Haplotype pairs constructed statistically...
Abstract Introduction Characterizing flavors are widely available in e-cigarettes and motivate initiation continued use. Flavors may enhance appeal facilitate development of addiction to tobacco products through modulation products’ reinforcing or aversive actions. Palatable (eg, fruit) increase primary properties. Menthol’s cooling anesthetic effects by counteracting nicotine’s effects. Genetics provide a method for modeling individual differences sensitivity A common polymorphism,...
Biotinidase deficiency is an inherited metabolic disorder characterized by neurological and cutaneous symptoms. Fortunately, it can be treated the symptoms prevented oral administration of vitamin biotin. Using dried blood-soaked filter paper cards, biotinidase activity was determined in sera 225,136 newborns Brazil. Mutation analysis performed on DNA from 21 babies with low serum confirmed that 3 had profound (less than 10% mean normal activity), 10 partial (10 to 30% 1 homozygous for...
Recent deep-sequencing efforts have identified many novel non-conserved small RNAs that are expressed at low levels in certain mammalian cells. Whether these important for physiology is debatable, therefore we explored the function of one such RNA, human miR-1271. This RNA similar sequence to miR-96, a highly conserved microRNA when mutated causes hearing loss humans and mice. Although miR-1271 miR-96 sequences differ slightly, our vitro assays indicate they an identical regulatory activity....
Functional variants that contribute to genomewide association study (GWAS) signals are difficult identify. MicroRNAs could some of these gene–trait relationships. We compiled a set GWAS trait gene SNPs were predicted affect microRNA regulation mRNA. Trait associations tested in sample 6725 European‐American (EA) and African‐American (AA) subjects interviewed using the polydiagnostic SSADDA diagnose major psychiatric disorders. A miR‐330‐3p target site SNP (rs41305272) mitogen‐activated...
Small RNAs modulate gene expression by forming a ribonucleoprotein complex with Argonaute proteins and directing them to specific complementary sites in target nucleic acids. However, the interactions required for recruitment of acid are poorly understood. In present manuscript we have investigated this question using let-7a, Argonaute2 fully mRNA target. Importantly, found that recombinant is sufficient direct let-7a guided cleavage mRNA. Thus model system has allowed us investigate...
Abstract Alcohol use contributes to numerous diseases and injuries. The nervous system is affected by alcohol in diverse ways, though the molecular mechanisms of these effects are not clearly understood. Using human-induced pluripotent stem cells (iPSCs), we developed a neural cell culture model identify alcohol’s effects. iPSCs were generated from fibroblasts differentiated into forebrain cultures that treated with 50 mM or sham conditions (same media lacking alcohol) for 7 days. We...