A5028706319- Folate and B Vitamins Research
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Amino Acid Enzymes and Metabolism
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Gut microbiota and health
- Pharmacological Effects and Toxicity Studies
- Alcoholism and Thiamine Deficiency
- Health, psychology, and well-being
- Peroxisome Proliferator-Activated Receptors
- Bioinformatics and Genomic Networks
- Child Nutrition and Feeding Issues
- Biochemical and Molecular Research
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Human Health and Disease
- Epigenetics and DNA Methylation
- Neurological and metabolic disorders
- Patient Satisfaction in Healthcare
- Computational Drug Discovery Methods
- Nerve injury and regeneration
Privolzhsky Research Medical University
2016-2024
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2021-2023
Ministry of Health of the Russian Federation
2020-2023
Research Medical Center
2022-2023
Abstract We provide an overview of the recent achievements in psychiatric genetics research Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, pharmacogenetic studies, with emphasis on genome-wide association studies. The genetic backgrounds mental illnesses polyethnic multicultural population are still understudied. Furthermore, genetic, genomic, data from not adequately represented international scientific literature, currently...
At least 50% of factors predisposing to alcohol dependence (AD) are genetic and women affected with this disorder present more psychiatric comorbidities, probably indicating different involved. We aimed run a genome-wide association study (GWAS) followed by bioinformatic functional annotation associated genomic regions in patients AD eight related clinical measures. A significant rs220677 (p-value = 1.33 × 10−8 calculated the Yates-corrected χ2 test under assumption dominant inheritance) was...
Currently, oxidative stress as part of the pathogenesis schizophrenia attracts much attention. In this regard, it becomes relevant to assess level redox imbalance in patients with schizophrenia, its impact on existing symptoms and possibility treatment. The antioxidant N-acetylcysteine is one potential drugs that affects stress.To study possibilities use schizophrenia.The included 20 diagnosed paranoid disease duration less than 3 years, randomly assigned main group (taking at a dose 2000 mg...
A wide range of studies have demonstrated that hyperhomocysteinemia is associated with the risk schizophrenia, but currently available assumptions about direct involvement homocysteine (Hcy) in pathogenesis schizophrenia are hypothetical. It possible vivo Hcy only a marker folate metabolism disturbances (which involved methylation processes) and not pathogenetic factor per se. Only one study has been conducted which associations oxidative stress (oxidative damage to protein lipids) found, it...
The search for new approaches to the mental disordersclassification is one of priority tasks in modern psychiatry. Current evaluate disorders isolation, ignoring fact that they are a multisystem pathology affects not only functions, but also wide range somatic manifestations. However, there more and reason consider as diseases. This approach interest explaining high comorbidity disorders, studying pathophysiological mechanisms determine risks course strategy can be basis fundamentally...
The aim of the investigation is to study carriage alleles folate cycle mTHFR677C>T polymorphism and assess cognitive function dynamics in course augmented antipsychotic therapy schizophrenic patients carrying defective mTHFR677T allele.Materials Methods.129 with schizophrenia underwent molecular diagnosing 677C>T mTHFR metabolism gene using PCR method allele-specific primers following on-line detection.of them 18 T allele received by folates.The were tested a standard battery tests before...
The first part of the literature review on role intestinal microbiota dysbiosis in pathogenesis autism spectrum disorders (ASD) includes recent data published features quantitative and qualitative composition patients with autism. It was shown that an excessive presence Clostridium detected ASD, evidence presented showing possible participation these bacteria development symptoms. Contradictory research results increase a number other pathogenic and, conversely, decrease necessary to...
To compare the severity of psychopathological symptoms and characteristics personal social functioning in patients with schizophrenia, carriers different alleles MTHFR677C>T polymorphism.One hundred fifty diagnosed schizophrenia were genotyped for polymorphism, some them examined using psychometric scales tests (PANSS, SANS, PSP, CDSS, a battery cognitive etc).Patients MTHFR677T variant had greater negative regardless instruments used study, disorder whole measured PANSS General subscale,...
To assess the dynamics of cognitive functions in patients with schizophrenia during intake various forms folate as an add-on to antipsychotic therapy.Using a battery tests, authors evaluated 3 groups who received folic acid (n=25), metafolin (n=25) 4 weeks and control group (n=25). Genetic variants polymorphism metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR. Only carriers minor T allele included study.The improvement certain was noted...
The purpose of this article is to highlight current ideas available in the world literature about high-risk state for psychosis as a promising diagnostic stage identification risk groups development schizophrenia near future, well allocate and characterize tools screening highrisk psychosis. Identification timely correction factors relevant method reducing incidence improving prognosis disease. As result data analysis with summary results original researches, systematic reviews meta-analyses...
BACKGROUND:Recentlyasignificant part of schizophrenia studies have been focused on the role cytokines, especially interleukin-6 (IL-6). Some authors suggestedapathogenetic for IL-6 in and concluded that therapy centers suppressing activity may prove beneficial certain categories patients with disorder. However, many questions about whether changes levels are primary, related to symptoms or caused by therapy, concomitant metabolic disorders, smoking other secondary factors remain...
The second part of the literature review on role intestinal microbiota disturbances in pathogenesis autism spectrum disorders (ASD) is devoted to analysis published possible mechanisms underlying impact dysbiosis function central nervous system and symptoms ASD vice versa, effect microbiota. hypotheses slow inflammation, hyperserotoninemia, production toxic metabolites microbiota, impaired wall permeability, synthesis amino acids, vitamins other biologically active substances that are...
Currently, a growing amount of data is emerging on the role various environmental factors (nutrients, gut microbiota, etc.) formation depression. The impact these can be effective not only in treatment major depressive disorder, but also its early prevention. Therefore, more detailed study depression lead both to better understanding etiology and pathogenesis disorder optimization approaches treatment. aim review was assess potential number associated with nutritional aspects characteristics...
To evaluate the association of serum folate levels with schizophrenia and its clinical characteristics in patients from a Russian sample.Ninety-three 60 healthy volunteers were examined. Determination was performed by chemiluminescent immunoassay on microparticles (Architect, Abbott Lab SA). Symptoms assessed Positive Negative Syndrome Scale, Calgary Schizophrenia Depression Snight-Hamilton Anhedonia Brief Assessment Cognition Schizophrenia, Personal Social Performance Scale for Therapy...