A5055858623- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Genomics and Rare Diseases
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Connective tissue disorders research
- Image Processing and 3D Reconstruction
- Genetic Associations and Epidemiology
- Human Health and Disease
- Electrolyte and hormonal disorders
- Vascular anomalies and interventions
- Animal Genetics and Reproduction
- Pediatric Urology and Nephrology Studies
- Forensic and Genetic Research
- Nutrition, Genetics, and Disease
- Ion Transport and Channel Regulation
- Evolutionary Algorithms and Applications
- Nerve injury and regeneration
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Effects of Exercise
Peter the Great St. Petersburg Polytechnic University
2021-2025
St Petersburg University
2014-2023
Astrakhan State Medical University
2021-2023
Research Centre for Medical Genetics
2022
Abstract The stone marten (Martes foina) is an important species for cytogenetic studies in the order Carnivora. ZooFISH probes created from its chromosomes provided a strong and clean signal chromosome painting experiments were valuable studying evolution of carnivoran genome architecture. research revealed that set similar to presumed ancestral karyotype Carnivora, which added additional value species. Using linked-read Hi-C sequencing, we generated chromosome-length assembly male (Gansu...
Background: Domestic cats enjoy an extensive veterinary medical surveillance which has described nearly 250 genetic diseases analogous to human disorders.Feline infectious agents offer powerful natural models of deadly diseases, include feline immunodeficiency virus, sarcoma virus and leukemia virus.A rich literature disease pathogenesis the demonstration a highly conserved ancestral mammal genome organization make cat annotation informative resource that facilitates multifaceted research...
Pusa sibirica, the Baikal seal, is only extant, exclusively freshwater, pinniped species. The pending issue is, how and when they reached their current habitat—the rift lake Baikal, more than three thousand kilometers away from Arctic Ocean. To explore demographic history genetic diversity of this species, we generated a de novo chromosome-length assembly, compared it with closely related marine Multiple whole genome alignment four species karyotypes showed high conservation chromosomal...
At least 50% of factors predisposing to alcohol dependence (AD) are genetic and women affected with this disorder present more psychiatric comorbidities, probably indicating different involved. We aimed run a genome-wide association study (GWAS) followed by bioinformatic functional annotation associated genomic regions in patients AD eight related clinical measures. A significant rs220677 (p-value = 1.33 × 10−8 calculated the Yates-corrected χ2 test under assumption dominant inheritance) was...
Sub-Saharan Africans infected with HIV-1C make up the largest AIDS patient population in world and exhibit large heterogeneity disease progression before initiating antiretroviral therapy. To identify host variants associated HIV progression, we performed genome-wide association studies on a total of 556 treatment-naive HIV-infected individuals Botswana. We characterized pattern using novel functional principal component analysis, which can better capture longitudinal CD4 viral load (VL)...
Abstract SWaveform, a newly created open genome-wide resource for read depth signal in the vicinity of structural variant (SV) breakpoints, aims to boost development computational tools and algorithms discovery genomic rearrangement events from sequencing data. SVs are dominant force shaping genomes substantially contributing genetic diversity. Still, there challenges reliable efficient genotyping whole genome data, thus delaying translation into clinical applications wasting valuable...
A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human samples sequenced by St. Petersburg State University Peterhof Sequencing Center three commercial centers outside Russia. The sequence quality, efficiency DNA variant were compared with each other microarrays study subjects. We assessed SNPs, indels, copy number variation, the speed WGS throughput promised. Twenty separate QC analyses showed high similarities among quality called...
Background:As genome-wide sequence analyses for complex human disease determinants are expanding, it is increasingly necessary to develop strategies promote discovery and validation of potential disease-gene associations.
Abstract The Puma lineage within the family Felidae consists of 3 species that last shared a common ancestor around 4.9 million years ago. Whole-genome sequences 2 from were previously reported: cheetah (Acinonyx jubatus) and mountain lion (Puma concolor). present report describes whole-genome assembly remaining species, jaguarundi yagouaroundi). We sequenced genome male with 10X Genomics linked reads assembled sequence. contains series scaffolds reach length chromosome arms is similar in...
Significance The search for genetic variants associated with resistance or susceptibility to HIV/AIDS already yielded insights that allowed developing therapeutics contribute dramatic reduction in AIDS-related comorbidities. Unfortunately, nearly all studies focused on European-descent populations, even though most infections happen Africa. In this genome-wide association study we explored the background of several hundred individuals from Botswana associations HIV infection. We discovered...
This paper describes a case report of renocardiac syndrome in child with non-inherited connective tissue disease (CTD). The importance CTD is accounted for by its high occurrence (up to 80%) and controversial interpretation phenotypic visceral signs. In children, combined diseases more commonly develop under the effects similar pathogenic factors or one impacts development another one. It was demonstrated that five organ systems are affected 20% children three 40% CTD. most common conditions...
CHaraCteristiCs oF sinus BradYCardia in YounG atHletes witH ComorBiditiesa b s t r a C -36 young athletes with bradycardia accompanied by comorbid conditions (vegetative symptoms and visceral manifestations of heart dysplasia) underwent an assessment creatine kinase-MB levels their blood serum the condition spectral components rate variability (HRV).It has been discovered that is more dependent on vegetative high sport loads than connective tissue dysplasia (CTD).However clinical features...
This literature review covers the pathophysiological features of water and sodium exchange in newborns. The main mechanisms regulating fluid electrolyte balance newborns are poorly studied. volume composition extracellular provided by functional activity kidneys under control neuroendocrine system. antidiuretic hormone plays role regulation excretion kidneys. intracellular depends on passive transport with participation aquaporins. Lability metabolism may be accompanied hyponatremia. For...
Abstract Summary We present pygenomics, a Python package for working with genomic intervals and bioinformatic data files. The implements interval operations, provides both API CLI, supports reading writing in widely used formats, including BAM, BED, GFF3, VCF. source code of pygenomics is provided in-source documentation type annotations adheres to the functional programming paradigm. These features facilitate seamless integration routines into scripts pipelines. implemented pure using its...