A5065042497- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Genetic Associations and Epidemiology
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Evolution and Genetic Dynamics
- Gene Regulatory Network Analysis
- Genomics and Rare Diseases
- Genetic diversity and population structure
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Zoonotic diseases and public health
- RNA and protein synthesis mechanisms
- HIV/AIDS Research and Interventions
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- Forensic and Genetic Research
- Nutrition, Genetics, and Disease
- Systemic Lupus Erythematosus Research
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- Epigenetics and DNA Methylation
Universitat Politècnica de Catalunya
2023-2024
Barcelona Supercomputing Center
2023-2024
St Petersburg University
2014-2021
Saint-Petersburg Research Institute of Phthisiopulmonology
2018
University of Glasgow
2018
Saint Petersburg Pasteur Institute
2018
Nova Southeastern University
2018
Tuberculosis (TB) poses a worldwide threat due to advancing multidrug-resistant strains and deadly co-infections with Human immunodeficiency virus. Today large amounts of Mycobacterium tuberculosis whole genome sequencing data are being assessed broadly yet there exists no comprehensive online resource that connects M. variants geographic origin, drug resistance or clinical outcome. Here we describe inclusive unifying Genome-wide Variation (GMTV) database, ( http://mtb.dobzhanskycenter.org )...
Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence association known mutations. We identify novel genome determinants related to bacterial virulence, pathogenicity, resistance.
A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human samples sequenced by St. Petersburg State University Peterhof Sequencing Center three commercial centers outside Russia. The sequence quality, efficiency DNA variant were compared with each other microarrays study subjects. We assessed SNPs, indels, copy number variation, the speed WGS throughput promised. Twenty separate QC analyses showed high similarities among quality called...
Panama remains free of zoonotic tuberculosis caused by Mycobacterium bovis. However, DNA fingerprinting 7 M. bovis isolates from a 2013 bovine outbreak indicated minimal homology with strains previously circulating in Panama. dispersion into highlights the need for enhanced genotype testing to track infections.
Background:As genome-wide sequence analyses for complex human disease determinants are expanding, it is increasingly necessary to develop strategies promote discovery and validation of potential disease-gene associations.
Mycobacterium tuberculosis is a highly studied pathogen due to public health importance. Despite this, problems like early drug resistance, diagnostics and treatment success prediction are still not fully resolved. Here, we analyze the incidence of point mutations widely used for resistance detection in laboratory practice conduct comparative analysis whole-genome sequence (WGS) clinical M. strains collected from patients with pulmonary (PTB) extra-pulmonary (XPTB) localization. A total 72...
Abstract Motivation Spatial Analysis of Functional Enrichment (SAFE) is a popular tool for biologists to investigate the functional organization biological networks via highly intuitive 2D maps. To create these maps, SAFE uses Spring embedding project given network into space in which nodes connected are near each other space. However, many scale-free, containing hub nodes. Because fails separate nodes, it provides uninformative embeddings that resemble ‘hairball’. In addition, only captures...
Significance The search for genetic variants associated with resistance or susceptibility to HIV/AIDS already yielded insights that allowed developing therapeutics contribute dramatic reduction in AIDS-related comorbidities. Unfortunately, nearly all studies focused on European-descent populations, even though most infections happen Africa. In this genome-wide association study we explored the background of several hundred individuals from Botswana associations HIV infection. We discovered...
Abstract Motivation Spatial Analysis of Functional Enrichment (SAFE) is a popular tool for biologists to investigate the functional organisation biological networks via highly intuitive 2D maps. To create these maps, SAFE uses Spring embedding project given network into space in which nodes connected are near each other space. However, many scale-free, containing hub nodes. Because fails separate nodes, it provides uninformative embeddings that resemble “hairball”. In addition, only captures...
Mycobacterium tuberculosisis a highly studied pathogen due to public health importance. Despite progress in M.tuberculosis genome diversity analysis, there remain insufficient data on analysis of strains associated with pulmonary vs. extrapulmonary TB (PTB or XPTB respectively) tissue localization. Here we conduct comparative whole-genome sequence (WGS) for clinical collected from patients PTB (n=72) and (n=73) We further analyze the incidence point mutations widely used drug resistance...