A5067007187- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Spaceflight effects on biology
- Acute Myocardial Infarction Research
- Acute Lymphoblastic Leukemia research
- Rabbits: Nutrition, Reproduction, Health
- Inflammasome and immune disorders
- Muscle metabolism and nutrition
- Glycosylation and Glycoproteins Research
- HIV/AIDS drug development and treatment
- Streptococcal Infections and Treatments
- Cardiac Imaging and Diagnostics
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Animal testing and alternatives
- Forensic and Genetic Research
Pirogov Russian National Research Medical University
2025
Kazan Federal University
2022
North-Western State Medical University named after I.I. Mechnikov
2019-2021
Omsk State Medical University
2018-2021
Omsk State Agrarian University
2021
St Petersburg University
2016
Institute of Cytology
2016
Technical University of Darmstadt
2012
Institute of Normal Physiology named after P.K. Anokhin
1984-2000
Academy of Medical Sciences
1997
A review of clinical studies indicates a high prevalence hypertension in pregnant women. Arterial women has negative impact on the course pregnancy and childbirth, as well health newborn. An analysis 150 SMADS information from EMIAS was carried out, according to which 30 with arterial were identified. SMAD profiles, office pressure measurements, body mass index (BMI), glucose levels analyzed. relationship age, presence concomitant diseases, duration pregnancy, outcome childbirth. The results...
Сarcinoembryonic antigen (CEA, CEACAM5, CD66) is a promoter of metastasis in epithelial cancers that widely used as prognostic clinical marker metastasis. The aim this study to identify the network genes are associated with CEA-induced colorectal cancer liver We compared genome-wide transcriptomic profiles CEA positive (MIP101 clone 8) and negative (MIP 101) cell lines different metastatic potential vivo. CEA-producing cells displayed quantitative changes level expression for 100...
The aim of this study was to compare the pyramidal neurons, their processes and synapses in stratum lucidum, radiatum lacunosum molecular layer field CA3 hippocampus brain white rats normal state after acute ischemia caused by a 20-minute occlusion common carotid arteries. Materials methods. In experiment, using histological methods (hematoxylin eosin, staining Nissle immunohistochemistry for p38, MAP-2) electron microscopy, neurons CA3, were studied. main group included animals reperfusion...
Aim : the aim of study was to investigate pleiotropic properties apoptotic enzyme caspase-3 and its associations with synaptic plasticity hippocampus albino rats in healthy animals after 20-min occlusion common carotid arteries. Material Methods . Total numerical density neurons, ultrastructure synapses, area immunohistochemically positive hippocampal terminals CA1 stratum radiatum lucidum CA3 were studied by methods optical microscopy (hematoxylin eosin stain), electron (uranyl acetate lead...
The purpose of the study was devoted to investigation nucleoli and related structures nucleus neurons in brain white rats normal after 20-minute occlusion common carotid arteries. Material methods. Structural types, tinctorial properties, number, shape, size distribution neuronal nuclei neocortex, hippocampus amygdala control (falsely operated animals, n=5) 1, 3, 7, 14 30 days (n=25) acute ischemia were studied by light (stained with hematoxilin eosin, according Nisl), electron (uranyl...
The aim of the study was to pyramidal neurons and astrocytes hippocampal CA 3 region in dynamics white rats after acute ischemia severe traumatic brain injury. Material methods. Acute simulated by 20-minute occlusion common carotid arteries (CCA), injury (TBI) a free-falling weight impact. Nissl staining, hematoxylin eosin immunohistochemical reactions for NSE, MAP-2, p38, GFAP were used study. proliferative activity cells assessed using Ki-67 response. carried out on thin (4 μm) serial...
The aimof research was to study morphofunctional signs of the sensorimotor "dark neurons" formation in cerebrum sexually mature white rats under normal conditions and 40 minutesafter common carotid arteries (CCA) occlusion. Material methods.Acute ischemia simulated Wistar by a 40-min CCA brain fixed immersion perfusion methods. A comparative morphometric assessment cyto-and gliocytoarchitectonics neocortex carried out (n = 6), 1 3 (n= 7 days 6) after Nissl staining, hematoxylin eosin...
The aim of the study is to evaluate neurons and synapses sensorimotor cortex, hippocampus amygdala brain white rats in normal state after 20-minute occlusion common carotid arteries. Material methods. Light microscopy, immunohistochemistry (synaptophysin or P38) morphometry were used total numerical density area sections synaptic terminals (n=5) 1, 3, 7, 14, 30 days (n=25) acute ischemia. Results. Within postischemic period, cortex layer III irreversible destruction have been 21.5% V 19.0%...
Purpose. The study is devoted to the of spatial organization white rats neocortex astrocytes in normal state and after 20-minute occlusion common carotid arteries (OCCA) from standpoint fractal formalism. Method research. Using histological (hematoxylin eosin staining, according Nisl), immunohistochemical (GFAP) methods morphometry, astrocyte bodies processes were studied on serial frontal sections sensorimotor cortex control (falsely operated animals, n = 15) 1, 3, 7, 14 30 days (n 25)...
Aim . To study the distribution and spatial organization of dentate gyrus (DG) astrocytes CA4 area hippocampus Wistar rats following 20-minute occlusion common carotid arteries (OCCA) compared to sham-operated control animals. Material methods Histological (Nissl staining with hematoxylin eosin), immunohistochemical (GFAP, MAP-2) morphometric were used. Astrocytes neurons in (sham-operated animals, n = 5) group, after 6 hours (n=5), 1 days 3 7 14 (n=5) 30 OCCA studied on thin (4 µm) serial...
The aim of the present study was to evaluate reactions autonomic neurones nodose ganglion vagus nerve, and stellate superior cervical ganglia in rabbits under emotional stress, correlate these with individual variations responses stressor. Emotional stress induced immobilized adult male Chinchilla by electrical stimulation ventromedial hypothalamus skin. During experiment (3 hours) arterial blood pressure (BP) recorded. Metabolic activities sympathetic were measured as contents biogenic...
The aim of the present investigation was to examine catecholamine content and activities synthesizing degrading enzymes in nodose ganglia rabbits with different patterns arterial blood pressure during exposure an acute emotional stressor. stress protocol involved immobilized adult male electrical stimulation ventromedial hypothalamus skin for 3 hours. Stress-resistant that had small fluctuations stressor significant reductions levels ofnorepinephrine (NE) ganglion hours exposure. In...
The aim of research was to study structural changes and give a morphometric characteristic the edemaswelling manifestations dentate gyrus (DG) hippocampal formation in sexually mature white rats after common carotid artery occlusion (OCCA) different duration ligation (LCCA) arteries. Material methods. Acute ischemia simulated adult Wistar by 20-, 30-, 40-min Histological (staining with hematoxylin-eosin, according Nissl), immunohistochemical (NSE, MAP-2, GFAP) techniques were used for...
Гипоксия является одним из ведущих патогенетических факторов формирования миокардиальной дисфункции в раннем посттравматическом периоде изолированного экспериментального ушиба сердца. Изменение активности соответствующих ферментов или изменения доступности определенных энергетических субстратов позволяет регулировать энергетический обмен условиях гипоксии. Современный подход к улучшению функции поврежденного миокарда – использование метаболических цитопротекторов. Триметазидин (25 мг/кг...