A5061694420- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Human Health and Disease
- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- Pediatric health and respiratory diseases
- HIV, TB, and STIs Epidemiology
- Acute Lymphoblastic Leukemia research
- Tuberculosis Research and Epidemiology
- Cytomegalovirus and herpesvirus research
- Respiratory and Cough-Related Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Endometriosis Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Reproductive System and Pregnancy
- Infective Endocarditis Diagnosis and Management
- Hematological disorders and diagnostics
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Congenital Heart Disease Studies
- Spondyloarthritis Studies and Treatments
- Herpesvirus Infections and Treatments
Samara State Medical University
2017-2025
Ministry of Health of the Russian Federation
2021-2022
Samara Regional Clinical Oncology Center
2022
Background . Timely diagnosis of systemic scleroderma (SS) can reduce the risk complications and disability in patients. However, correct is complicated by diversity disease clinical forms variants. Clinical case description SS a boy under 5 years old was considered as congenital skin hemiatrophy, thus he observed dermatologist (treatment without effect). Methotrexate prednisolone therapy administered at age after diagnosing SS. Subungual ulcers distal phalanges osteolysis appeared further...
Background. Rheumatoid arthritis (RA) is one of the most common and severe immune-inflammatory diseases in humans associated with a great medical socio-economic burden. RA can have significant impact on family planning fertility; women fewer children than expected, patients tend to take longer achieve desired pregnancy. Measuring anti-Müllerian hormone (AMH) levels important assessing ovarian reserve (OR). There are many studies OR, but no generally accepted tools available identify...
Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It still debatable whether early intensive treatment superior in terms earlier achievement remission. The aim this study was to evaluate effectiveness etanercept+methotrexate (ETA+MTX) combination therapy versus step-up MTX monotherapy with ETA added refractory disease. A multi-centre, double-blind, randomized active polyarticular JIA patients treated either ETA+MTX (n = 35) or placebo+MTX 33) for up 24...
The authors summarized publications on the risk to develop tuberculosis during treatment of rheumatic diseases with genetically engineered biologic drugs. article describes approaches optimization control activities in patients diseases: immunodiagnostics latent infection and prevention disease receiving biological
Objective: to study the features of clinical and epidemiological characteristics whooping cough in children Samara region. Materials methods : 389 cases pertussis region for 2015–2016 were analyzed. Results it is shown that spite 95–98% vaccination coverage, recent years there has been an increase incidence cough. Seasonality morbidity remains. Among observed, youngest not vaccinated against pertussis. The picture disease remains typical with classic course catarrhal spasmodic periods....
Introduction . Acute respiratory viral infections in children remain an urgent problem, not only because of the high incidence, but also a significant contribution to mortality structure young children. Approaches treatment acute are considered, taking into account possibility impact drugs on main links pathogenesis and prevention complications from perspective bioregulatory approach therapy complex drugs. The purpose study To present effectiveness clinical pathogenetic aspects disease....
The homotoxicology and antihomotoxic therapy are a relatively new branches in medicine involving an alternative approach to allopathic treatment. A holistic treating patient on the basis of principles implements practice provision “not treat disease, patient”. Unlike medicines, most drugs don’t have embryotoxic, teratogenic, mutagenic phetotoxic effects, cause drug addiction dependencies due content active substances plant, animal, mineral origin. This is widely applying them obstetric...
Introduction . The relevance of the problem rhinosinusitis in different ages is due to their high prevalence. article presents information with approaches treatment children, which allow preventing irreversible changes mucous membrane nasal cavity and paranasal sinuses. importance eliminating dysregulation biological networks underlying disease noted. Such capabilities are possessed by means bioregulatory medicine. Aim study : To carry out a comparative analysis effectiveness chronic...
Background. Destructive joint damages in juvenile arthritis inevitably lead to persistent disability adulthood. These consequences can be avoided by resorting early therapy of the disease. Objective . Our aim was assess dynamics destructive changes idiopathic (JIA) children, depending on a basic therapy. Methods We studied treatment results children with systemic-onset JIA active syndrome without systemic manifestations hospitalized regional clinical cardiological health center. activity...
Purpose of the study: to assess state nonspecific immunity in women with relapsing herpetic infection, planning pregnancy, period gestation, from infants and children first six months life, depending on method prophylaxis relapses infection intrauterine infection. Patients methods: under observation were 342 pregnant their children. Testing for presence HSV was performed using methods PCR ELISA. Women studied: interferon status, indicators phenotyping lymphocytes, levels tumor necrosis...
<h3>Background</h3> Remission is the major goal of treatment juvenile idiopathic arthritis(JIA). Advances in options allowed achievement remission to come into reach. Timing for initiating intensive a treat target approach early reach still debate. <h3>Objectives</h3> Multi-centre, double-blind, randomised study polyarticular JIA patients (pts) receiving either Etanercept+Methotrexate (cohort 1) or Placebo +Methotrexate 2) 24 weeks followed by week open label phase. Escape open-label ETN and...
Objectives - to improve a method of assessment for adaptive capacity children with tonsillitis in course acute infectious diseases, based on the parameters autonomic nervous system. Material and methods. The prospective study included clinical, anamnestic laboratory examination diseases concurrent syndrome. factors under underwent systematic multivariate analysis. Results. Heart rate variability was assessed following comparative statistical analysis acquired data. By mathematical modeling...
Aim to determine the prevalence of acute rheumatic fever (ARF) in children and chronic heart disease (HRHD) adults on example Samara region propose measures for early detection prevention valvular lesions. Material methods. The authors cite material their own research, indicating a significant etiology lesions that required surgical treatment 20162020 region. We retrospectively analyzed out-patients large polyclinic city. Results. study demonstrates low frequency Russian Federation along...