A5006983127- melanin and skin pigmentation
- Forensic and Genetic Research
- Nutrition, Genetics, and Disease
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Digestive system and related health
- Linguistics and Cultural Studies
- RNA regulation and disease
- Eurasian Exchange Networks
- Indigenous Studies and Ecology
- Race, Genetics, and Society
- Diet, Metabolism, and Disease
- Regional Socio-Economic Development Trends
- Linguistics and language evolution
- Methane Hydrates and Related Phenomena
- Herpesvirus Infections and Treatments
- Historical and Archaeological Studies
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Helicobacter pylori-related gastroenterology studies
- Marine and environmental studies
- BRCA gene mutations in cancer
- T-cell and Retrovirus Studies
- Soviet and Russian History
Central Bank of the Russian Federation
2022-2024
Research Centre for Medical Genetics
2020-2024
Amur State University of Humanities and Pedagogy
2020
Vavilov Institute of General Genetics
2020
Kemerovo State Medical Academy
2020
Abstract Objectives The collection of genotype data was conducted as an essential part a pivotal research project with the goal examining genetic variability skin, hair, and iris color among Kazakh population. has practical application in field forensic DNA phenotyping (FDA). Due to limited size databases from Central Asia (Kazakhstan), it is practically impossible obtain individual identification result based on profiling short tandem repeats (STRs). However, pervasive use FDA necessitates...
Pusa sibirica, the Baikal seal, is only extant, exclusively freshwater, pinniped species. The pending issue is, how and when they reached their current habitat—the rift lake Baikal, more than three thousand kilometers away from Arctic Ocean. To explore demographic history genetic diversity of this species, we generated a de novo chromosome-length assembly, compared it with closely related marine Multiple whole genome alignment four species karyotypes showed high conservation chromosomal...
Abstract Background Predicting the eye and hair color from genotype became an established widely used tool in forensic genetics, as well studies of ancient human populations. However, accuracy this has been verified on West Central Europeans only, while populations border regions between Europe Asia (like Caucasus Ural) also carry light pigmentation phenotypes. Results We phenotyped 286 samples collected across North Eurasia, genotyped them by standard HIrisPlex-S markers found that...
ДЕМОГРАФИЧЕСКИЙ ПОРТРЕТ КОРЯКОВ СЕВЕРА КАМЧАТКИÌàòåðèàëû è ìåòîäû.Ïðîâåäåí àíàëèç äåìîãðàôè÷åñêîé ñòðóêòóðû ïîïóëÿöèè êîðÿêîâ íà ñòûêå àðåàëîâ êîðåííûõ ìàëî÷èñëåííûõ íàðîäîâ -êîðÿêîâ, ÷óê÷åé ýâåíîâ.Äåìîãðàôè÷åñêèå ïîêàçàòåëè (ïîë, âîçðàñò, ñîñòàâ ñåìüè, òèï áðàêîâ) äëÿ òðåõ ñåë Îëþòîðñêîãî ðàéîíà Êàì÷àòñêîãî êðàÿ ðàññ÷èòàíû îñíîâå êíèã ïîõîçÿéñòâåííîãî ó÷åòà íàñåëåíèÿ (íà 2018 ã
МОЗАИКА ГЕНОФОНДА ЭВЕНКОВ: ЗАБАЙКАЛЬСКИЙ И АМУРСКИЙ СЕГМЕНТЫ Ìàòåðèàëû è ìåòîäû. Ãåíîôîíä äâóõ ãðóïï âîñòî÷íûõ ýâåíêîâ -çàáàéêàëüñêèõ (N=50) àìóðñêèõ (N=81) -èçó÷åí ïî ïîäðîáíîé ïàíåëè 60 SNP ìàðêåðîâ Y-õðîìîñîìû. Àíàëèç ÷àñòîò âûÿâëåííûõ ãàïëîãðóïï ïðîâåäåí ìåòîäàìè ìíîãîìåðíîé ñòàòèñòèêè ãåíîãåîãðàôèè
Currently available genetic tools effectively distinguish between different continental origins. However, North Eurasia, which constitutes one-third of the world's largest continent, remains severely underrepresented. The dataset used in this study represents 266 populations from 12 Eurasian countries, including most ethnic diversity across Russia's vast territory. A total 1,883 samples were genotyped using Illumina Infinium Omni5Exome-4 v1.3 BeadChip. Three principal components computed for...
The correlation between the risk of death from COVID-19 and patient's ethnogeographic origin has been previously detected. LZTFL1 gene was identified as a potential marker two times higher severe COVID-19. study aimed to assess spatial variation in SNP markers indigenous populations Russia world. Spatial polymorphic analyzed 28 metapopulations (97 ethnic groups) North Eurasia (n = 1980) 34 world's 3637) by bioinformatics, statistical cartographic methods. In Eurasia, major geographic...
The introduction of pharmacogenetic tests among the Russian population faces a fundamental limitation — pronounced genetic differences between populations. geography markers deoxyribonucleic acid (DNA) helps to remove these limitations. Aim . To reveal spatial variation gene pools indigenous European in terms DNA that are significant for pharmacotherapy cardiovascular diseases (CVDs) using biobank collections. Material and methods A total 3170 samples from 61 populations Biobank Northern...
ГЕНОФОНД ТРЕХ ВОСТОЧНЫХ РОДОВ ТУВИНЦЕВ ПО ДАННЫМ ПОЛИМОРФИЗМА Y ХРОМОСОМЫÌàòåðèàëû è ìåòîäû.Âïåðâûå èçó÷åí ãåíîôîíä òðåõ òóâèíñêèõ ðîäîâ êîë, îþí õåðòåê ïî øèðîêîé ïàíåëè SNP-ìàðêåðîâ Y-õðîìîñîìû.Íà îñíîâå ÷àñòîò ãàïëîãðóïï ïðîâåäåí ìíîãîìåðíûé ñòàòèñòè÷åñêèé àíàëèç, ïîñòðîåíû êàðòû ãåíåòè÷åñêèõ ðàññòîÿíèé, îòðàçèâøèå ïîëîaeåíèå â ãåîãðàôè÷åñêîì ïðîñòðàíñòâå Ñèáèðè Öåíòðàëüíîé Àçèè.Âûáîðêè áûëè ñôîðìèðîâàíû èç ìóae÷èí, íå ñâÿçàííûõ ðîäñòâåííûìè îòíîøåíèÿìè,
ВведениеÍà ñåâåðå Êàì÷àòñêîãî êðàÿ, ñîåäèíÿþùèì ïîëóîñòðîâ ñ ìàòåðèêîì, ïåðåñåêëèñü òðè ïîòîêà êîðåííîãî íàñåëåíèÿ ñåâåðî-âîñòî÷íîé îêîíå÷íîñòè Åâðàçèè: äðåâíåå íàñåëåíèå ×óêîòêè (÷óê÷è), Êàì÷àòêè (êîðÿêè) è î÷åíü ïîçäíèé (XIX âåêà) ïîòîê òóíãóñîâ (ýâåíû).Äåìîãðà-ôè÷åñêèå ïîðòðåòû íàðîäîâ, íûíå aeèâóùèõ íà ïåðåñå÷åíèè ýòèõ òðåõ ïîòîêîâ, ìîãóò ñëóaeèòü ïðèáëèçèòåëüíîé àíàëîãîâîé ìîäåëüþ âçàèìîäåéñòâèÿ ìåaeäó êîðåííûìè íàðîäàìè ñåâåðà Åâðàçèè â óñëîâèÿõ ðàñòóùåãî
Genetic contribution of pre-Slavic populations to gene pools modern Russia is increasingly relevant, along with genetic footprints the Golden Horde invasion. The novel genome-wide approaches enable advanced solutions in this field. study aimed at searching for interaction among Finnicspeaking, Slavic and Turkic-speaking Central Volga Region their reflection pharmacogenetic landscape. Modeling ancestral components by ADMIXTURE software mapping involved genotyping data 248 individual genomes...
Introduction. The question of whether the Alans left a genetic heritage in modern population North Caucasus, and if they did, which populations carry it their gene pool, is not only problem basic science, but also an acute issue public discussion. Population genetics can test hypothesis preserving contribution thousand-year history Alanian tribes to pools peoples Caucasus. Materials methods. genomes 207 individuals (on panel 4.5 million markers) were studied: Abkhazians, Adyghes, Balkarians,...
Introduction. The Y-gene pool of the southern Tuvan tribal groups – Soyan and Choodu was first studied their comparative analysis with representatives Kyrgys (south-east Tuva) Oorzhak (west carried out. Purpose study: to determine genetic status within landscape population Southern Siberia. Materials methods. sample (total N=150) included samples from (N=42), (N=29), (N=46) (N=33) groups. genotyping panel 60 SNP-markers Y-chromosome, characteristic populations Northern Eurasia. Results. In...
Background: Eastern Finnic populations, including Karelians, Veps, Votes, Ingrians, and Ingrian Finns, are a significant component of the history which have developed over ~3 kya. Yet, these groups remain understudied from genetic point view. Methods: In this work, we explore gene pools Karelians (Northern, Tver, Ludic, Livvi), Finns using Y-chromosome markers (N = 357) genome-wide autosomes 67) in comparison with selected Russians populations area 763). The data analyzed statistical,...
Introduction. Trehalose or mushroom sugar has been increasingly used in the food industry past decades. To be absorbed human intestine, trehalose needs to broken down by an enzyme known as trehalase. Today, it is that G→A substitution rs2276064 locus of TREH gene results reduced activity this enzyme. The aim study was analyze frequency (rs2276064) alleles and genotypes populations South Siberia, Kazakhstan, Central Asia Mongolia differ contribution ancestral East Eurasian (Mongoloid)...
The gene pool of the East Caucasus, encompassing modern-day Azerbaijan and Dagestan populations, was studied alongside adjacent populations using 83 Y-chromosome SNP markers. analysis genetic distances among 18 (N = 2216) representing Nakh-Dagestani, Altaic, Indo-European language families revealed presence three components (Steppe, Iranian, Dagestani) that emerged in different historical periods. Steppe component occurs only Karanogais, indicating a recent medieval migration Turkic-speaking...
Significant differences between the gene pools of Russian peoples require development ethno- regional adapted pharmacogenetic tests and identification priority regions for their implementation. Aim. To develop a genogeographic technology to identify selection effects using example biomarkers that are significant pharmacotherapy patients with cardiovascular diseases (CVD), population biobank Pharmacogenetics Populations Russia Adjacent Countries database. Material methods . Deoxyribonucleic...
The peculiarity of the Russian North gene pool has long become scientific fact, but yet to receive informative explanation. Genetic drift cannot be only contributing factor in striking genetic differences between not northern populations and southern ones, among individual as well. Studying pools previously underrepresented literature may help understand this phenomenon. work aimed perform a subtotal study Arkhangelsk Oblast Pomors (Onega Coast, Summer western fragment Winter Coast; n = 130)...
ВведениеÃåíîôîíä ëþáîãî íàðîäà ÿâëÿåò ñîáîé ñëîaeíûé êîâåð
Финансирование.Исследование выполнено в рамках исследовательской темы «Антропология евразийских популяций» (АААА-А19-119013090163-2) НИИ и Музея антропологии МГУ (медико-антропологический анализ) Государственного задания для ФГБНУ «МГНЦ» (геногеографический анализ).Проведение биоинформатического определения частот аллелей большинстве популяций поддер
Eastern Caucasus is home to more than 30 peoples speaking Caucasian, Iranian and Turkic languages. Fusion of multiple migration flows together with the complex population structure make it difficult analyze its gene pool: this most poorly studied one among all regions Caucasus. The study aimed identify main patterns autosomal pool variation in region. A total 356 genomes 29 ethnic groups were using large panels SNP markers: 243 22 113 7 living adjacent regions. bioinformatics analysis...
Genetic testing of each patient aimed at detecting the pharmacogenetic marker carrier state is challenging for healthcare system. However, knowledge about frequencies pharmacogenetically important genes enables making decisions treatment based on patient’s ethnicity. The CYP2C19 cytochrome gene involved in biotransformation a broad spectrum drugs one most important. study was to determine major variants and patterns their spatial variability population Russia. database Pharmacogenetics...