A5035370202- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Paleontology Studies
- Animal Genetics and Reproduction
- Bat Biology and Ecology Studies
- Genetic and phenotypic traits in livestock
- Genomics and Chromatin Dynamics
- Primate Behavior and Ecology
- Animal Diversity and Health Studies
- Plant Virus Research Studies
- Environmental DNA in Biodiversity Studies
- Genomic variations and chromosomal abnormalities
- Gene expression and cancer classification
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Reproductive Biology
- Genetics, Bioinformatics, and Biomedical Research
- Microbial Community Ecology and Physiology
- Plant Genetic and Mutation Studies
- CRISPR and Genetic Engineering
- Genetic and Environmental Crop Studies
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
Siberian Branch of the Russian Academy of Sciences
2016-2025
Institute of Molecular and Cell Biology
2016-2025
Russian Academy of Sciences
2009-2023
Novosibirsk State University
2014-2020
International Atomic Energy Agency
2018
National Cancer Institute
2008-2014
Texas A&M University
2012
Oregon State University
2012
Veterinary Research Institute
2012
Institute of Chemical Biology and Fundamental Medicine
2011
To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis 48 species representing all orders Neoaves using phylogenomic methods created to handle data. We recovered highly resolved tree that confirms previously controversial sister or close relationships. identified first divergence in Neoaves, two groups named Passerea and Columbea, independent lineages diverse convergently evolved land water bird species. Among Passerea, infer common ancestor core...
Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, transform human genome. However, primate taxonomy is both complex controversial, with marginal unifying consensus evolutionary hierarchy extant species. Here we provide new sequence (∼8 Mb) from 186 representing 61 (∼90%) described genera, include outgroup species Dermoptera, Scandentia, Lagomorpha. The resultant phylogeny exceptionally robust illuminates events in...
Patterns of genetic and genomic variance are informative in inferring population history for human, model species endangered populations. Here the genome sequence wild-born African cheetahs reveals extreme depletion SNV incidence, density, SNVs coding genes, MHC class I II mitochondrial DNA SNVs. Cheetah genomes on average 95 % homozygous compared to outbred domestic cat (24.08 homozygous), Virunga Mountain Gorilla (78.12 %), inbred Abyssinian (62.63 Tasmanian devil, dog other mammalian...
Abstract Strains of red fox ( Vulpes vulpes ) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as Russian farm-fox experiment. Here we sequenced and assembled genome re-sequenced a subset foxes from tame, aggressive conventional farm-bred populations to identify genomic regions associated response selection for behaviour. Analysis genomes identified 103 either significantly decreased heterozygosity one three or...
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin a female woolly mammoth (†Mammuthus primigenius) died 52,000 years ago retained its architecture. We use PaleoHi-C map chromatin contacts assemble genome, yielding 28 chromosome-length scaffolds. Chromosome territories, compartments, loops, Barr bodies, inactive X chromosome (Xi) superdomains persist. The active...
The Afrotheria, a supraordinal grouping of mammals whose radiation is rooted in Africa, strongly supported by DNA sequence data but not their disparate anatomical features. We have used flow-sorted human, aardvark, and African elephant chromosome painting probes applied reciprocal schemes to representatives two the Afrotherian orders, Tubulidentata (aardvark) Proboscidea (elephants), an attempt shed additional light on evolutionary affinities this enigmatic group mammals. Although we yet...
The recent rise in speed and efficiency of new sequencing technologies have facilitated high-throughput sequencing, assembly analyses genomes, advancing ongoing efforts to analyze genetic sequences across major vertebrate groups.Standardized procedures acquiring high quality DNA RNA establishing cell lines from target species will facilitate these initiatives.We provide a legal methodological guide according four standards storing tissue for the Genome 10K Project similar initiatives as...
Most eukaryotic species represent stable karyotypes with a particular diploid number. B chromosomes are additional to standard and may vary in size, number morphology even between cells of the same individual. For many years it was generally believed that found some plant, animal fungi lacked active genes. Recently, molecular cytogenetic studies showed presence copies protein-coding genes on chromosomes. However, transcriptional activity these remained elusive. We studied Siberian roe deer...
Naked mole rat (NMR) is the long-lived and tumor-resistant rodent. NMRs possess multiple adaptations that may contribute to longevity cancer-resistance. However, whether have more efficient DNA repair not been directly tested. Here we compared base excision (BER) nucleotide (NER) systems in extracts from NMR mouse fibroblasts after UVC irradiation. Transcript levels of key enzymes demonstrated most cases higher inducibility vs cells. Ratios activities somewhat varied depending on...
Researchers have assembled thousands of eukaryotic genomes using Illumina reads, but traditional mate-pair libraries cannot span all repetitive elements, resulting in highly fragmented assemblies. However, both chromosome conformation capture techniques, such as Hi-C and Dovetail Genomics Chicago long-read sequencing, Pacific Biosciences Oxford Nanopore, help resolve regions therefore improve genome One important livestock species arid that does not a high-quality contiguous reference is the...
The role of chromosome rearrangements in driving evolution has been a long-standing question evolutionary biology. Here we focused on ruminants as model to assess how may have contributed the gene regulation. Using reconstructed ancestral karyotypes Cetartiodactyls, Ruminants, Pecorans, and Bovids, traced patterns gross changes. We found that lineage leading ruminant ancestor after split from other cetartiodactyls was characterized by mostly intrachromosomal changes, whereas pecoran...
Abstract The spotted hyena ( Crocuta crocuta ), one of the largest terrestrial predators native to sub-Saharan Africa, is well known for its matriarchal social system and large-sized group in which larger females dominate smaller males. Spotted hyenas are highly adaptable as they both actively hunt prey scavenge kills by other predators, possess an enhanced hypercarnivorous dentition that allows them crack open bones thereby feed on nearly all parts a carcass. Here, we present high-quality...
Chromosome homologies between the Japanese raccoon dog (<i>Nectereutes procyonoides viverrinus, </i>2n = 39 + 2–4 B chromosomes) and domestic (<i>Canis familiaris,</i> 2n 78) have been established by hybridizing a complete set of canine paint probes onto high-resolution G-banded chromosomes dog. Dog 1, 13, 19 each correspond to two chromosome segments, while remaining 35 autosomes single segment. In total, 38 autosome paints revealed 41 conserved segments in The use...
Chromosomal evolution in carnivores has been revisited extensively using cross-species chromosome painting. Painting probes derived from flow-sorted chromosomes of the domestic dog, which one most rearranged karyotypes mammals and highest dipoid number (2n=78) carnivores, are a powerful tool detecting both evolutionary intra- inter-chromosomal rearrangements. However, only few comparative maps have established between dog other non-Canidae species. Here, we extended painting with to seven...
Abstract The stone marten (Martes foina) is an important species for cytogenetic studies in the order Carnivora. ZooFISH probes created from its chromosomes provided a strong and clean signal chromosome painting experiments were valuable studying evolution of carnivoran genome architecture. research revealed that set similar to presumed ancestral karyotype Carnivora, which added additional value species. Using linked-read Hi-C sequencing, we generated chromosome-length assembly male (Gansu...
We have made a set of chromosome-specific painting probes for the American mink by degenerate oligonucleotide primed-PCR (DOP-PCR) amplification flow-sorted chromosomes. The were used to delimit homologous chromosomal segments among human, red fox, dog, cat and eight species family Mustelidae, including European mink, steppe forest polecats, least weasel, mountain Japanese sable, striped polecat, badger. Based on results chromosome G-banding, comparative maps between these been established....