О. В. Хлынова
A5033741869- Healthcare Systems and Public Health
- Inflammatory Bowel Disease
- Human Health and Disease
- Cardiovascular Disease and Adiposity
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Microscopic Colitis
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Biomarkers in Disease Mechanisms
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- Rheumatoid Arthritis Research and Therapies
- Cardiac Health and Mental Health
- Cardiac Fibrosis and Remodeling
- Thermoregulation and physiological responses
- Endometriosis Research and Treatment
- Medical and Agricultural Research Studies
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders
- Diet and metabolism studies
Perm State Medical Academy
2016-2025
Ministry of Health of the Russian Federation
2020-2023
Perm State University
2021
Federal State Budgetary Institution "Federal Center For Cardiovascular Surgery" Ministry of Health of The Russian Federation
2021
Russian Academy of Sciences
2020
Perm Regional Oncology Center
2020
.
.
.
Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
.
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney (CKD) are two global public health problems that affect almost 30% up to ~10-15%, respectively, of the general adult population in many parts world. It is quite obvious NAFLD a “multisystem disease” associated not only with impaired function development hepatocellular carcinoma, but also an increasing risk developing cardiovascular diseases (the main cause death such patients), (CKD). However, mechanisms underlying this association...
The relevance of the problem . Late diagnosis gonarthritis (GA) based on radiological criteria determines a decrease in effectiveness chondroprotective drugs (CD). aim is to identify early changes hyaline cartilage knee joints and evaluate therapy at an stage disease. Materials methods 186 patients with high risk GA were examined. All signed informed consent. 119 took CD for two years, 67 did not receive therapy. control group consisted 31 healthy people without factors. Initially 2 years...
Objective. To assess the effect of coronavirus infection on development true arthritis in patients with post-COVID joint syndrome Materials and methods. Factors contributing to rheumatic disease confirmed were evaluated a prospective cohort study. General clinical immunological tests, including markers rheumatoid determined. Results. On basis results this study, it was found out that COVID-19 may act as trigger for autoimmune diseases. Conclusions. The study indicate role Preventive measures...
The Russian Cross-disciplinary Consensus on the diagnositic and treatment of spondyloarthritis (SpA) in inflammatory bowel diseases (IBD) was prepared initiative Loginov Moscow Clinical Scientific Center, using Delphic system. Its purpose to consolidate opinions experts most actual issues diagnosis concomitant immuno-inflammatory (SpA IBD). An interdisciplinary approach is provided by participation leading gastroenterologists rheumatologists. working group analyzed domestic foreign...
Aim . The clinical guidelines are intended to provide information support for making decisions by gastroenterologists, general practitioners and internists that will improve the quality of medical care patients with non-alcoholic fatty liver disease, taking into account latest data principles evidence-based medicine. Key points Clinical contain about current views on etiology, risk factors pathogenesis nonalcoholic peculiarities its course. Also given recommendations methods laboratory...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
It is known that iron deficiency a negative factor for the onset of pregnancy. aggravates its course, increasing risk preeclampsia, placental insufficiency, uterine inertia, premature birth, bleeding and hypogalactia. This condition increases unfavorable outcomes, anemia cognitive delay in child. Raising awareness women reproductive age clinical suspicion physicians regarding latent can facilitate timely visit doctor. At expert council "Relevant issues Russian Federation" held June 2020,...
At present, the problem of concomitant diseases still remains very important for medical science as well practice. Arterial hypertension is one most actual global healthcare problems, holding leading place among cardiovascular diseases. Acid-related diseases, including gastroesophageal reflux disease and duodenal ulcer are also widely-spread with tendency prevalence growth, having gastrointestinal The combination arterial acid-related a new state an organism regulation. Their synchronism not...
.
Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical course complications COVID-19 during hospitalization extracted from electronic health records using a...
BACKGROUND. There is enough evidence of the negative impact excess weight on formation and progression res piratory pathology. Given continuing SARS-CoV-2 pandemic, it relevant to determine relationship between body mass index (BMI) clinical features novel coronavirus infection (NCI). AIM. To study effect BMI course acute SARS-COV-2 post-covid period. MATERIALS AND METHODS. AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping...
Inflammatory bowel diseases (IBD) are one of the most complex and significant problems modern gastroenterology. The steady increase in morbidity, pathogenetic mechanisms development, presence severe extra-intestinal manifestations complications make this problem socially significant. article presents views on some aspects pathogenesis IBD. Currently, key links development progression IBD, as well associated cardiovascular state intestinal microbiota level endotoxemia. role trimethylamine...
Цель исследования: определить вклад анамнестических, клинико-лабораторных и инструментальных параметров в возникновение риска летального исхода у больных инфарктом миокарда (ИМ) молодого среднего возраста предложить модель стратификации этого для данной когорты пациентов.Дизайн: сплошное проспективное регистровое исследование
Aim. To study the prevalence of various C807T polymorphism variants ITGA2 gene and to analyze association this with platelet aggregation activity in hypertensive patients.
 
 Methods. 47 patients arterial hypertension treated at Clinical Cardiology Dispensary (Perm) were included study. Genotyping (rs 1126643) was carried out by method polymerase chain reaction subsequent identification single nucleotide polymorphic variant allele-specific reaction. Platelet investigated impedance...