A5080751775- Metabolism and Genetic Disorders
- Spondyloarthritis Studies and Treatments
- Mitochondrial Function and Pathology
- Myofascial pain diagnosis and treatment
- Alcoholism and Thiamine Deficiency
- Microscopic Colitis
- Nutrition, Genetics, and Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone health and treatments
- Neurogenetic and Muscular Disorders Research
- Aluminum Alloy Microstructure Properties
- Human Health and Disease
- Inflammatory Bowel Disease
- Folate and B Vitamins Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects and Toxicity Studies
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Adrenal Hormones and Disorders
- Histiocytic Disorders and Treatments
- Therapeutic Uses of Natural Elements
- Aluminum Alloys Composites Properties
- Celiac Disease Research and Management
- Diet and metabolism studies
Russian Medical Academy of Continuous Professional Education
2020-2024
Ministry of Health of the Russian Federation
2020-2024
VA Nasonova Scientific Research Institute of Rheumatology
2020-2021
Samara Federal Research Scientific Center
2019
The Russian Cross-disciplinary Consensus on the diagnositic and treatment of spondyloarthritis (SpA) in inflammatory bowel diseases (IBD) was prepared initiative Loginov Moscow Clinical Scientific Center, using Delphic system. Its purpose to consolidate opinions experts most actual issues diagnosis concomitant immuno-inflammatory (SpA IBD). An interdisciplinary approach is provided by participation leading gastroenterologists rheumatologists. working group analyzed domestic foreign...
The paper reviews literature on locomotor apparatus injury in inflammatory bowel disease (IBD). It describes the types of joint and spinal column involvement ulcerative colitis (UC) Crohn’s (CD). ratio onset to activity IBD articular syndrome is estimated. most common type peripheral arthritis that involves mainly knee ankle joints associated with cases. Unlike arthritis, course axial spondyloarthritis manifesting as isolated sacroiliitis ankylosing spondylitis (AS) unrelated activity. There...
Chronic pain is the main manifestation of musculoskeletal diseases (MSDs), leading to deterioration quality life and loss ability work. The importance this problem determined by widespread prevalence MSDs, osteoarthritis (OA), acute chronic non-specific back (NBP), periarticular soft tissues lesions. Introduction effective methods treatment (MSP) into medical practice one fundamental tasks modern medicine. pathogenesis MSP includes mechanisms such as injury, inflammation, peripheral...
Erdheim–Chester disease (ECD) is a rare with poor prognosis. The first two cases were reported by Jakob Erdheim and William Chester in 1930. etiology incidence are unknown. One of the main components this disorder chronic uncontrollable inflammation. In 2016 ECD was classified as histiocytic neoplasm World Health Organization categorized “tumors histiocytes dendritic cells”. More than half patients testing positive for BRAF mutation. final diagnosis made on basis histological finding. There...
Abstact: Phenylketonuria is a hereditary disease associated with metabolic disorder of amino acids in the organism, prevalence which Russian Federation 1:10000.Currently, main treatment phenylketonuria diet therapy specialized health food (a mixture without phenylalanine).This research presents results comparison medicinal mixtures MDmil PKU line taken from first month life child compared to other producers, later periods.Efficiency analysis based on data provided by major regional genetics...
Purpose: Demonstrate the possible manifestations of SAPHO syndrome. Material and methods: 38-year-old woman with suspected syndrome were performed scintigraphy SPECT/CT for evaluate localization abundance process. Results: Osteosclerosis hyperostosis left clavicle, osteosclerosis L1 vertebra other, less pronounced changes, accompanied by active accumulation 99mTc-MDP, revealed. Conclusion: It is important to remember specific complex symptoms this nosological entity isolated onset individual...
The Gleeble-3800 unit was used to simulate physically the upsetting of cast and hot rolled semi-finished products from aluminum-lithium alloy V-1461 over temperature range 400-460°C strain rates 1-60 s -1 . Following texture analysis upset samples showed most typical preferred crystallographic orientations its formation features depending on temperature-strain rate schedules. recrystallization type at a 60 is distinctive feature samples’ behavior during deformation. In general, established...
Purpose: Is to demonstrate functional and structural changes in the musculoskeletal system of patient with ochronosis using bone scan hybrid imaging consisting single-photon emission computed tomography (SPECT) X-ray transmission (CT) (SPECT/CT).
 Material methods: A clinical case report ochronosis, examined SPECT/CT.
 Results: In this article we show a picture mineral metabolism disorder severe degenerative (a genetically determined disease), caused by metabolic disorders...
Background: Objectives: To assess the bone mineral density (BMD) of skeleton using Hologic Discovery A DXA, determine frequency low-energy skeletal fractures among adult patients with alkaptonuria (AKU), and identibjectivefy factors that affect occurrence fractures. Methods: AKU is a rare genetic disease (1 case per 250,000) which occur to severe damage spine large joints. Serious problem in this category decrease BMD. The study included 40 reliable diagnosis (23 men 17 women) aged from 33...
Background. Alkaptonuria is an orphan, autosomal recessive disease in which clinical symptoms debut adulthood and are characterized by progressive degenerative changes large joints (knee, hip, shoulder) the spine, often leading to need for joint replacement. Developing lead persistent disability.
 The purpose of this study was evaluate disability among adult patients with alkaptonuria.
 Materials methods. included 46 (31 m 67.4% 15 w 32.6%) a reliable diagnosis alkaptonuria at age...
Alkaptonuria is rare autosomal recessive multisystem disease, caused by mutations in the homogentisine oxidase gene, which leads to deposition of metabolites homogentisic acid organs and tissues (ochronosis). The purpose: study spectrum ophthalmic manifestations alkaptonuria Russian cohort patients different ages. Material methods. Ophthalmological examination 9 patients: 5 adults aged from 39 64 years 4 children 3 6 with confirmed diagnosis “alkaptonuria” was performed. Results. In all...
The aim of the study was to quality life patients with alkaptonuria. Material and methods. included 50 a reliable diagnosis alkaptonuria aged 18 78 years (mean age 58.2±10.8 years). Among them, men predominated (n=31; 62%), in most cases (98%) complaining pain joints and/or spine. For first time, articular syndrome debuted at 17 39 (average debut – 29.4±4.76 duration clinical manifestations disease before ranged from 7 47 23.35±8.17 74% had disability group. In cohort, body mass index (BMI)...
Alkaptonuria is a rare autosomal recessive disease. In these patients, melanin-like compounds as the final products of impaired metabolism homogentisic acid are deposited mainly in connective tissue, including cartilage tissue intervertebral discs. Similar to other degenerative spine diseases, lumbar segment often damaged. The authors report 67-year-old patient with alkaptonuria. Compression cauda equina by damaged masses discs and ligaments deposits ochronotic pigment described. Previously...