М. Ф. Осипенко
A5008706459- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Celiac Disease Research and Management
- Biosimilars and Bioanalytical Methods
- Diet, Metabolism, and Disease
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Veterinary medicine and infectious diseases
- Gut microbiota and health
- Pharmaceutical studies and practices
- Digestive system and related health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Human Health and Disease
- Intestinal Malrotation and Obstruction Disorders
- Alcohol Consumption and Health Effects
- Therapeutic Uses of Natural Elements
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
Novosibirsk State Medical University
2016-2025
Ministry of Health of the Russian Federation
2015-2023
Omsk State Medical University
2023
Institute of Cytology and Genetics
2021
Research Institute of Therapy and Preventive Medicine
2021
Vitebsk State Medical University
2017
The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing delineated structural and functional configurations metagenomes world populations. microbiota Russian population is particular interest to researchers, because Russia encompasses uniquely wide range environmental conditions ethnogeographical cohorts. Here we conduct shotgun metagenomic analysis samples from 96 healthy adult subjects, which reveals novel structures....
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CT-P13 subcutaneous (SC), an SC formulation of the intravenous (IV) infliximab biosimilar IV, creates a unique exposure profile. The LIBERTY studies aimed to demonstrate superiority vs placebo as maintenance therapy in patients with Crohn's disease (CD) and ulcerative colitis (UC).
Aim of publication. To present indications for antihelicobacter therapy, methods and sequence diagnostics eradication treatment Helicobacter pylori (H. pylori) infection to general practitioners. Key points. Chronic gastritis caused by H. infection, including that in «asymptomatic» patients can be considered an indication therapy both as etiological opportunistic screening gastric cancer prevention. Indications obligatory include stomach a duodenum peptic ulcer (PU), MALT-lymphoma, early...
Abstract Background CT-P13 subcutaneous (SC) infliximab formulation showed comparable efficacy and safety with intravenous (IV) in inflammatory bowel disease (IBD)1 rheumatoid arthritis2. This study aimed to demonstrate the superiority of SC over placebo as maintenance therapy after induction IV patient Crohn’s (CD). Methods Moderately severely active CD patients activity index (CDAI) score 220 450 simplified endoscopic for (SES-CD) ≥6 points ileal-colonic or ≥4 including ulcer from at least...
Background : Epidemiological studies performed in different countries have identified a number of trends that allow to predict the problems related prevalence inflammatory bowel diseases (IBD), their severity and healthcare resources utilization. Aim To present comparative results two large epidemiological IBD Russian Federation (RF), i.e. ESCApe ESCApe-2. Materials methods Two multicenter cross-sectional cohort with similar design were at three-year interval. The had common aim: identify...
Aim. The clinical guidelines are intended to supplement specialty decision-making for improved aid quality in patients with gastritis and duodenitis though acknowledging the latest evidence principles of evidencebased medicine. Key points. Gastritis is an inflammatory disease stomach mucosa, a separate definition acute chronic gastritis. Chronic cohort diseases uniting typical morphology persistent infiltration, impaired cellular renewal emergent intestinal metaplasia, atrophy epithelial...
The Russian Cross-disciplinary Consensus on the diagnositic and treatment of spondyloarthritis (SpA) in inflammatory bowel diseases (IBD) was prepared initiative Loginov Moscow Clinical Scientific Center, using Delphic system. Its purpose to consolidate opinions experts most actual issues diagnosis concomitant immuno-inflammatory (SpA IBD). An interdisciplinary approach is provided by participation leading gastroenterologists rheumatologists. working group analyzed domestic foreign...
To review the results of open observational study Makhaon on use a fixed combination glycyrrhizic acid (GA) and ursodeoxycholic (UDCA) (Phosphogliv Urso) for treatment abdominal pain, assessment contractile function gallbladder bile rheology in patients with stage I cholelithiasis. The included 330 subjects, 44.5% males 55.5% females. participants were 18-70 years old, mean age 43.8±0.6 years. In 2021-2022, treated 14 clinical centers 10 cities Russian Federation: Moscow, St. Petersburg,...
Aim : to present the results of an Expert Consensus on standardization indications for surgical treatment gastroesophageal reflux disease (GERD). Materials and methods . The issues GERD were discussed by 39 experts – leading gastroenterologists surgeons from 7 cities Russia, representing 17 institutions. list questions discussion was formed initiative group sent experts. reviewed recent literature, including existing clinical guidelines consensuses, assessed evidence base suggested...
Aim . The clinical guidelines are intended to provide information support for making decisions by gastroenterologists, general practitioners and internists that will improve the quality of medical care patients with non-alcoholic fatty liver disease, taking into account latest data principles evidence-based medicine. Key points Clinical contain about current views on etiology, risk factors pathogenesis nonalcoholic peculiarities its course. Also given recommendations methods laboratory...
Abstract Background and Aims In the LIBERTY Phase 3 studies in Crohn’s disease (CD) or ulcerative colitis (UC), maintenance CT-P13 subcutaneous (SC) 120 mg was more effective than placebo after 1 year. Here we report 2-year data from open-label extensions. Methods Two randomized, placebo-controlled, double-blind evaluated efficacy safety of SC moderate-to-severe CD UC. Responders to intravenous induction were randomized at Week (W) 10 biweekly, until W54. From W22, dose adjustment 240...
Aim : bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure diagnostics eradication therapy Н . pylori infection. Key points Chronic gastritis caused by infection, including asymptomatic persons, may be considered as an indication Н. etiological opportunistic screening gastric cancer prevention. Indications, obligatory include peptic ulcer, MALT lymphoma, early (EGC) with endoscopic resection. H. primary 13 C-urea breath test, stool antigen...
Background. Recently, there has been an increase in the prevalence of gastroesophageal reflux disease (GERD) Northern Europe, North America and East Asia. However data on GERD Russian population are very limited. Aim. To determine among Russia, clinical spectrum symptoms, main drugs used for treatment, rate their administration. Materials methods. The study was conducted from November 2015 to January 2017 8 cities Russia. A survey patients over age 18 years old visiting outpatient medical...
Aim . Current clinical recommendations are intended to supply gastroenterologists, physicians and general practitioners with modern methods for the diagnosis treatment of constipation. Key points Constipation is defined as primary (functional) secondary form, latter comprising a manifestation another illness. The causes constipation diagnosed colonoscopy, especially in patients aged over 50 having “anxiety symptoms” hereditary colorectal oncological predisposition. Indications may also...
Aim: to present modern methods of diagnosis and treatment chronic pancreatitis for gastroenterologists, general practitioners physicians. Chronic (CP) is a long-term inflammatory disease the pancreas, manifested by irreversible morphological changes in parenchyma pancreatic ducts, which cause pain and/or persistent impairment function. Current concept on etiology CP reflected TIGAR-O classification. The criteria establishing include typical attacks abdominal clinical laboratory signs...
1Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov State University of Medicine Dentistry, Ministry Health Russia, 3Kazan Medical University, Kazan; 4Kazan (Volga) Federal 5Far Eastern Khabarovsk; 6Morozov City Children’s Hospital, 7I.I. Mechnikov North-Western Saint Petersburg; 8Siberian Tomsk; 9M.F. Vladimirsky Regional Institute, 10Maimonides Classical Academy, 11V.I. Razumovsky Saratov Saratov; 12I.M. Sechenov First 13S.M. Kirov Military...
Efficacy and safety of new subcutaneous (SC) formulation CT-P13 (CT-P13 SC) up to Week 30 were comparable with intravenous (IV) in both patients Crohn's disease1 (CD) rheumatoid arthritis.2 The aim this study was report pharmacokinetics (PK), efficacy overall SC CD throughout the 1-year treatment period. Patients moderate-to-severe (CDAI score 220–450) administered IV 5 mg/kg at Weeks 0 2, randomised into four cohorts 6. Cohort 1 received every 8 weeks Cohorts 2–4 120 mg, 180 240 mg,,...
An analysis of the most important changes and provisions Maastricht VI consensus published in August 2022 is presented. 41 experts from 29 countries took part creation consensus. Recommendations have been developed five areas: (1) indications for treatment clinical associations Helicobacter pylori (H. pylori) infection, (2) diagnosis, (3) treatment, (4) prevention gastric cancer, (5) H. microbiota -intestinal tract (GIT), taking into account level evidence strength recommendations. Emphasis...
1Moscow Clinical Research-and-Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov State University of Medicine and Dentistry, Ministry Health Russia, 3Children’s Research 4I.I. Mechnikov North-Western Medical University, Saint Petersburg; 5M.F. Vladimirsky Regional Institute, 6Russian Academy Postgraduate Education, 7Novosibirsk Novosibirsk; 8Russian Children’s Hospital, 9Department Pediatrics, Russian 10I.P. Pavlov First Petersburg 11Acad. Yu.E. Veltishchev Institute...
Background: CT-P13 is a biosimilar of innovator infliximab (INX) and has been approved for all indications by the European Medicines Agency in 2013 Food Drug Administration 2016. Methods: This study was randomised, double-blind, parallel-group, phase III conducted patients with moderate to severe CD. The primary objective compare efficacy between INX terms Crohn's Disease Activity Index (CDAI)-70 response rates at Week 6. CDAI-70 CDAI-100 were defined as reductions from baseline CDAI score...
To assess the clinical practice of diagnosis and treatment in patients with Helicobacter pylori infection to compare this international guidelines European Registry on management infection, Hp-EuReg protocol), a multicenter prospective observational study initiated by Microbiota Study Group. MATERIALs AND METHODS: The data 813 infected H. entered register Russian centers 2013-2015 were analyzed.The most common methods for primary are histology (40.3%), rapid urease test (35.7%), serology...