A5002156538- Prenatal Screening and Diagnostics
- Plant Molecular Biology Research
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Plant Disease Resistance and Genetics
- Plant Pathogens and Resistance
- Plant Pathogens and Fungal Diseases
- Plant and animal studies
- Biochemical effects in animals
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Plant Stress Responses and Tolerance
- Receptor Mechanisms and Signaling
- BRCA gene mutations in cancer
- Fern and Epiphyte Biology
- Plant nutrient uptake and metabolism
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Plant biochemistry and biosynthesis
- Chemical Synthesis and Analysis
- Plant Physiology and Cultivation Studies
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Parvovirus B19 Infection Studies
- Plant Diversity and Evolution
InnoGenomics (United States)
2024
Moscow Institute of Physics and Technology
2017-2022
Engelhardt Institute of Molecular Biology
2012-2017
Lomonosov Moscow State University
2002-2017
Scientific Center of Children's Health
2015-2016
Pirogov Russian National Research Medical University
2015-2016
Russian Children's Clinical Hospital
2016
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2013
Russian Academy of Sciences
2012-2013
Federal Medical-Biological Agency
2012
The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing delineated structural and functional configurations metagenomes world populations. microbiota Russian population is particular interest to researchers, because Russia encompasses uniquely wide range environmental conditions ethnogeographical cohorts. Here we conduct shotgun metagenomic analysis samples from 96 healthy adult subjects, which reveals novel structures....
Cultivated flax (Linum usitatissimum L.) is widely used for production of textile, food, chemical and pharmaceutical products. However, various stresses decrease production. Search genes, which are involved in stress response, necessary breeding adaptive cultivars. Imbalanced concentration nutrient elements soil yields also results heritable changes some lines. The appearance Linum Insertion Sequence 1 (LIS-1) the most studied modification. LIS-1 function still unclear. High-throughput...
Cultivated flax (Linum usitatissimum L.) is an important plant valuable for industry. Some lines can undergo heritable phenotypic and genotypic changes (LIS-1 insertion being the most common) in response to nutrient stress are called plastic lines. Offspring of lines, which stably inherit changes, genotrophs. MicroRNAs (miRNAs) involved a crucial regulatory mechanism gene expression. They have previously been assumed take part can, therefore, participate genotroph formation. In present...
Amaryllidaceae is a large family with more than 1,600 species, belonging to 75 genera. The largest genus— Allium —is vast, comprising about thousand species. species (as well as other members of the ) are widespread and diversified, they adapted wide range habitats from shady forests open like meadows, steppes, deserts. genes present in chloroplast genomes (plastomes) play fundamental roles for photosynthetic plants. Plastome traits could thus be associated geophysical abiotic...
Acid soils limit agricultural production worldwide. Major reason of crop losses in acid is the toxicity aluminum (Al). In present work, we investigated expression alterations microRNAs flax ( Linum usitatissimum L.) plants under Al stress. Flax seedlings resistant (TMP1919 and G1071/4_k) sensitive (Lira G1071/4_o) to cultivars lines were exposed AlCl 3 solution for 4 24 hours. Twelve small RNA libraries constructed sequenced using Illumina platform. total, 97 from 18 conserved families...
SSAP method was used to study the genetic diversity of 22 Linum species from sections Linum, Adenolinum, Dasylinum, Stellerolinum, and 46 flax cultivars. All studied varieties were distinguished using for retrotransposons FL9 FL11. Thus, validity demonstrated marking, identification accessions in genebank collections, control during propagation varieties. Polymorphism Fl1a, Fl1b, Cassandra insertions very low varieties, but these successfully investigation species. Species clusterization...
Genetic data plays an increasingly important role in modern medicine. Decrease the cost of sequencing with subsequent increase imputation accuracy, and accumulation large amounts high-quality genetic enable creation polygenic risk scores (PRSs) to perform genotype-phenotype associations. The accuracy phenotype prediction primarily depends on overall trait heritability, Genome-wide association studies cohort size, similarity background between base target cohort. Here we utilized 8,664 high...
The species relationships within the genus Linum have already been studied several times by means of different molecular and phylogenetic approaches. Nevertheless, a number ambiguities in phylogeny still remain unresolved. In particular, sections Stellerolinum Dasylinum need further clarification. Also, question independence section Adenolinum remains unanswered. Moreover, L. narbonense other require Additionally, origin tetraploid (2n = 30) including cultivated usitatissimum has not...
Ferns are large and underexplored group of vascular plants (~ 11 thousands species). The genomic data available by now include low coverage nuclear genomes sequences partial mitochondrial for six species several plastid genomes. We characterized three Dryopteris, which is one the largest fern genera, using sequencing chloroplast DNA enriched samples performed comparative analysis with plastomes Polypodiales, most species-rich ferns. also sequenced plastome Adianthum hispidulum (Pteridaceae)....
A fast adoption of a non-invasive prenatal testing (NIPT) in clinical practice is global tendency last years. Firstly, Russia according new regulation it was possible to perform widescale pregnant women chromosomal abnormality risk. The aim the study-to assess efficiency using NIPT as second-line first trimester screening test Moscow.Based on combined results 12,700 were classified high-risk (cut-off ≥ 1:100) and an intermediate-risk 1:101 - 1:2500) groups followed by whole genome NIPT....
The genetic diversity of strawberry F. x ananassa varieties with respect to FaRE1 LTR retrotransposon integration sites was studied for the first time. SSAP method a single combination primers revealed 35 polymorphic in genome. Most (36 out 46) had unique combinations insertions but 5 pairs did not differ their markers. Assessment similarity using markers reveal distinct clusters, which may be explained by relatively short history selection this cultivar and crossing within same pool.
More than 275 million people in the world are carriers of a heterozygous mutation CFTR gene, associated with cystic fibrosis, most common autosomal recessive disease among Caucasians. Some recent studies assessed association between variants and some pathologies, including cancer risk. The aim this study is to analyze landscape germline pathogenic patients diagnosed malignant neoplasms. For first time Russia, we evaluated frequency by whole-genome sequencing 1800 compared frequencies control...
Summary Branchio‐oculo‐facial syndrome (BOFS, OMIM# 113620) is a rare autosomal dominant disorder characterised by branchial cleft sinus defects, ocular anomalies and facial dysmorphisms, including lip or palate pseudocleft, associated with mutations in the TFAP2A gene. Here, we performed clinical analysis mutation diagnostics seven BOFS patients Russia. The phenotypic presentation of observed three showed high heterogeneity, variation its main manifestations (linear loci cervical cutaneous...
MicroRNAs (miRNAs) control a variety of biological processes and are involved in plant response to abiotic stress including phosphate starvation. Phosphate deficiency is one the major limiting factors for crop yield. In present work inorganic responsive miRNAs were identified flax first time by high-throughput sequencing. Three conserved miRNA families (miR398, miR399 miR408) differentially expressed under other species it was demonstrated that these combination different stresses....
Multiple studies of hepatitis B virus (HBV) genetic variability and its relationship with the disease pathogenesis are currently ongoing, stemming from growing evidence clinical significance HBV mutations. It is becoming increasingly evident that patients hematologic malignancies may be particularly prone to a higher frequency such The present report first extensive study prevalence escape mutations in S-HBsAg, performed using isolates 59 hospital hematology departments diagnoses leukemia (n...
The objective — To assess the effectiveness of including NIPT in structure prenatal diagnostics Moscow. Material and Methods Totally 5,181 pregnancies undergoing screening for fetal trisomy using during period from 01.04.2020 to 30.09.2020 Russia. According results biochemical blood test, patients were divided into two groups: group high risk (cut-off ≥1:100) (n=208) intermediate 1:101 – 1:2500) (n=4,973). Patients at high-risk cell-free DNA (cfDNA) offered an invasive procedure, followed by...