A5082677130- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hepatitis Viruses Studies and Epidemiology
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- SARS-CoV-2 detection and testing
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Yersinia bacterium, plague, ectoparasites research
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Human Health and Disease
- Macrophage Migration Inhibitory Factor
- Medical and Agricultural Research Studies
- Peripheral Artery Disease Management
- Corneal Surgery and Treatments
- Immunotherapy and Immune Responses
Lomonosov Moscow State University
2024
MIREA - Russian Technological University
2024
Ministry of Health of the Russian Federation
2015-2024
The University of Texas MD Anderson Cancer Center
2004-2022
Leukemia Research Foundation
2019-2022
S. M. Kirov Military Medical Academy
2022
Gamalei Institute of Epidemiology and Microbiology
2017-2021
National Centre for Research and Development
2019
National Research Centre
2019
Royal Adelaide Hospital
2019
Nasopharyngeal swab (NPS) and oropharyngeal (OPS) are the most widely used upper respiratory tract specimens for diagnosis of SARS-CoV-2 using RT-qPCR. In contrast, nasal (NS) saliva (SS), recently recommended by WHO, rarely used, their test accuracy is limited. The method direct RT-PCR detection does not require an RNA extraction faster easier than standard tests with extraction. This study aimed to compare diagnostic performance samples without preliminary heat inactivation. Here we report...
Immune-escape hepatitis B virus (HBV) mutants play an important role in HBV spread. Recently, the multivalent vaccine Bubo®-Unigep has been developed to protect against both wild-type and most significant G145R mutant. Here, we compared effects of recombinant HBsAg antigens, mutated at G145R, included new vaccine, on activation a human high-density culture peripheral blood mononuclear cells (PBMC) vitro. The antigens were used either alone or combination with phytohemagglutinin (PHA). None...
Over the past decade, mRNA-based therapy has displayed significant promise in a wide range of clinical applications. The most striking example leap development mRNA technologies was mass vaccination against COVID-19 during pandemic. emergence large-scale technology and positive experience immunization sparked antiviral anti-cancer vaccines as well therapeutic agents for genetic other diseases. To facilitate delivery, lipid nanoparticles (LNPs) have been successfully employed. However,...
7018 Background: Fms-like tyrosine kinase 3 (FLT3) mutations, both internal tandem duplication (ITD) and point occur in approximately 30% of pts with AML confer poor prognosis. Sorafenib is an oral multi-kinase inhibitor highly potent against mutant FLT3 (IC 50 1–3 nM). Based on preclinical data, this study was initiated to assess two intermittent administration schedules sorafenib. Methods: This phase I trial evaluated the safety efficacy sorafenib 15 refractory/relapsed (n=14) or high-risk...
Multiple studies of hepatitis B virus (HBV) genetic variability and its relationship with the disease pathogenesis are currently ongoing, stemming from growing evidence clinical significance HBV mutations. It is becoming increasingly evident that patients hematologic malignancies may be particularly prone to a higher frequency such The present report first extensive study prevalence escape mutations in S-HBsAg, performed using isolates 59 hospital hematology departments diagnoses leukemia (n...
One of the important reasons for spreading hepatitis B virus (HBV) under conditions vaccinepressure is emergence escape mutations. Prevalent G145R mutation in S-gene leads to most expressed changes serological properties HBV. Consequently, HBsAg modifed so thoroughly that it cannot be recognized by majority anti-HBs. Mutant also differs from a wild type its immunogenic properties. At present, relevance enhancement vaccine view mutant variants has been recognized.a comparative study antigenic...
Fundamental immunobiology of proinflammatory cytokines and MIF There are a lot similarity as well differences when we compare with according their biological properties. characteristics unique structure, organs tissues ubiquity, extremely wide variety functions (proinflammatory cytokine, enzyme, hormone), ability to be induced by glucocorticoid hormones affects immunosuppressive effects antagonist. exists in preformed condition lymphocytes, macrophages endothelium cells. It secrets these...
Sensitive and reliable diagnostic test systems based on real-time PCR are of great importance in the fight against ongoing SARS-CoV-2 pandemic. The genetic variability virus leads to accumulation mutations, some which may affect sensitivity modern assays. aim this study was search Russian clinical samples for new mutations gene N that can detection by RT-PCR. In study, polymorphisms regions target causing failed or poor RT-PCR assay 12 selected were detected. Sequencing entire E genes these...
Introduction. The nature of a cellphone electromagnetic radiation (EMP) influence on the neutrophils in vitro activation was studied. relevance studying impact mobile communications and their effects body’s physiological processes is determined by global prevalence such tools research data inconsistency both domestic foreign scientific literature. Material methods. object study whole venous blood samples isolated from 36 adult donors (aged 22 to 65 years) genders. responses neutrophils’...
Oral cavity squamous cell carcinoma (OC-SCC) is the most common and aggressive malignancy of oral cavity. Recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for development, while distinguished role Epstein-Barr (EBV) remains still uncertain. However, evidence association between infection controversially varies significantly by geographic regions race.The aim present study was to elucidate prevalence HPV EBV in OC-SCC samples Russian...
The high prevalence of the hepatitis B virus (HBV) in population occurs mainly due to numerous mechanisms formed process evolution, contributing its survival under immunological pressure. review presents most complete systematization and classification various HBV protective basing on their influence different parts congenital adaptive immune response. analysis literature data allows for conclusion that two basic principles underlie mechanisms: strategy «stealth virus» (virus’s escape from...
Accumulation of escape mutants hepatitis B virus (HBV) occur in the many countries at conditions wide-scale vaccination against B, especially among vaccinated children. The real prevalence such is underestimated and capacity current vaccines to provide cross-immunity G145R mutant almost completely absent. potential for spread strains accumulates. Consequently, a question about need change design arises with purpose expansion their action spectrum. An approach inclusion pre-S epitopes into...
In terms of serological properties and immunization, the wild type HBsAg HBV its G145R mutant behave as different antigens. This testifies to serious structural changes, which presumably could have a significant impact on morphogenesis virions subviral particles. Nevertheless, morphological ultrastructural investigations with mutation not been carried yet.Research organization in presence escape mutation.Studies sera, purified viruses recombinant were out by transmission electron microscopy...
Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with historical overall survival (OS) of 8–14 months from diagnosis. Tagraxofusp a targeted therapy directed to CD123, target highly expressed on BPDCN. The pivotal trial results presented here provided the basis for FDA approval tagraxofusp treatment BPDCN in adult and pediatric patients 2 years or older, marketing authorization application (MAA) under review. Aims: Determine recommended...
3194 Background: We previously demonstrated that intravenously (IV) injected bone marrow-derived mesenchymal stem cells (MSC) integrate into solid tumors as stromal fibroblasts and proliferate selectively in situ. here propose a novel cancer therapy concept based on the intratumoral drug production by gene-modified MSC. Methods: MSC were transduced with adeno (AdV)- or adeno-associated (AAV) virus carrying marker- therapeutic genes. Gene-modified IV mice xenografts. Results: found only...
Please indicate where the abstract has been published before: part of this clinical trial (AZA+Nivo) was in Cancer Discovery 2018. Background: PD-1 positive CD8 T-cells were increased bone marrow (BM) patients (pts) with relapsed AML (Williams et al., 2018). Azacitidine up-regulates and interferon-gamma signaling (Yang Leukemia 2013). Aims: To determine safety, response rate overall survival (OS) for Aza+Nivo Aza+Nivo+Ipi identify immunological molecular biomarkers response. Methods: Pts...