A5007198728- Microbial infections and disease research
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- T-cell and Retrovirus Studies
- Hepatitis C virus research
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Toxin Mechanisms and Immunotoxins
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Physics of Superconductivity and Magnetism
- Virus-based gene therapy research
- Digestive system and related health
- Diabetes and associated disorders
- ZnO doping and properties
- Complex Network Analysis Techniques
- Helicobacter pylori-related gastroenterology studies
- Legionella and Acanthamoeba research
- Probiotics and Fermented Foods
- Galectins and Cancer Biology
National Research Centre
2018-2024
Ministry of Health of the Russian Federation
2011-2024
National Centre for Research and Development
2024
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences
2023
Gamalei Institute of Epidemiology and Microbiology
1991-2018
G.V. Kurdyumov Institute for Metal Physics
1999-2000
National Academy of Sciences of Ukraine
2000
Russian Academy of Sciences
1997-1999
Etravirine is approved for use in treatment-experienced patients at a dose of 200 mg twice daily. Efavirenz has been associated with greater increases serum lipids compared other non-nucleosides randomized trials first-line treatment. In this double-blind, placebo-controlled trial, 157 treatment-naive HIV RNA >5000 copies/mL were 1 : to either 400 etravirine once daily (n = 79) or 600 efavirenz 78) plus two nucleoside analogues (either abacavir/lamivudine, zidovudine/lamivudine...
This study investigated strategies that may increase the yield of drug resistance testing prior to starting antiretroviral therapy (ART), and whether transmitted polymorphic resistance-associated mutations (RAMs) correlated with virological outcomes. We carried out retrospective baseline samples from patients entering SENSE trial first-line ART in Europe, Russia Israel. Prior randomization etravirine or efavirenz plus two nucleos(t)ide reverse transcriptase inhibitors (NRTIs), plasma...
Hepatitis C virus (HCV) is one of the major causes chronic liver disease and leads to cirrhosis hepatocarcinoma. Despite extensive research, there still no vaccine against HCV. In order induce an immune response in DBA/2J mice HCV, we obtained modified mouse mesenchymal stem cells (mMSCs) simultaneously expressing five nonstructural HCV proteins (NS3-NS5B). The innate mMSCs was higher than DNA immunization, with plasmid encoding same proteins, naïve unmodified MSCs. triggered strong...
The coronavirus disease (COVID-19) pandemic has brought into sharp relief the threat posed by coronaviruses and laid foundation for a fundamental analysis of this viral family, as well search effective anti-COVID drugs. Work is underway to update existent vaccines against COVID-19, screening low-molecular-weight drug candidates outpatient medicine continues. opportunities ways accelerate development antiviral drugs other pathogens are being discussed in context preparing next pandemic. In...
The critical current density of YBa2Cu3O7-films dc magnetron sputtered onto buffered (CeO2) sapphire substrates is measured. peculiarities these dependences are interpreted by taking into account the crystal defect (edge dislocations) film structure which in turn determined growth mode.
Multiple studies of hepatitis B virus (HBV) genetic variability and its relationship with the disease pathogenesis are currently ongoing, stemming from growing evidence clinical significance HBV mutations. It is becoming increasingly evident that patients hematologic malignancies may be particularly prone to a higher frequency such The present report first extensive study prevalence escape mutations in S-HBsAg, performed using isolates 59 hospital hematology departments diagnoses leukemia (n...
Abstract. Phosphorilated polyprenols (PP) isolated from different sources are known to exert immunomodulating and antiviral activities. In this paper possible anti-inflammatory action of PP were studied using sensitive models 5-lypoxigenase 15-lypoxigenase activity inhibition, as well a model the hypostasis induced by complete Freundt’s adjuvant, or carraginan. Also in vitro bronchospasm was used study prospective broncholytic PP. The latter found dose-dependent inhibitory effect upon both...
Identification of a natural mutation the ccr5 gene in humans which makes them resistant to HIV-1 infection, has opened new direction for development alternative treatment approaches through genome editing. The human immunodeficiency virus, when infecting CD4+ cells, uses one two chemokine co-receptors plasma membrane. During infection and early stages strains using CCR5 protein circulate, while later ones use CXCR4 protein. It cannot be ruled out that there is complex relationship regulation...
As assessed by decreased response of ConA-induced blasts to IL-2, a staphylococcal protein A was shown extract IL-2 from cultural medium after its preincubation with IgG, but it did not bind pure IL-2. Normal human immunoglobulin inhibits reaction DTH effectors Listeria antigen, which is also IL-2-dependent. An immunomodulating drug Phosprenyl (sodium polyprenylphosphate) abolishes the inhibitory ffect immunoglobulin. Since (as earlier) interacts alpha-chain rIL-2 and blocks activity, two...
The aim of the study — demonstration capabilities new generation geographic information system software and agent-based modeling for solving epidemiological problems (on example spread measles in a metropolis).Materials methods. Examples use thematic layers functionality geoinformation platform, as well developed multi-agent model megalopolis, are given. is presented following three independent sub-models or nested models: behavior model, infection infectious process model. modularity...
Наровлянский А.Н
Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led development new emulsion compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. third component is immunomodulator. Adjuvants, intended for prevention virus infections, should include immunomodulators polarizing immune response Th1. From this point view colloidal solution prepared by means from polyprenyl phasphates fir needles...
Hepatitis C virus (HCV) is one of the basic culprits behind chronic liver disease, which may result in cirrhosis and hepatocarcinoma. In spite extensive research conducted, a vaccine against HCV has not been yet created. We have obtained human mesenchymal stem cells (hMSCs) used them for expressing NS5A protein as model vaccination platform. Sixteen hMSC lines different origin were transfected with pcNS5A-GFP plasmid to obtain genetically modified MSCs (mMSCs). The highest efficiency was by...
The aim of the research was to study population composition splenic lymphoid cells, assess functional activity lymphocytes as well state gastrointestinal tract microbiota in experimental modeling metabolic syndrome (MS). studies were conducted using two models MS and hyperlipidemia (HL), based on prolonged drinking animals with 20% aqueous fructose solution added cholesterol intraperitoneal administration Poloxamer 407 mice, respectively. results experiments indicate a change splenocytes...
Objective. The work was performed with the purpose to study microbiota state of gastro-intestinal tract (GIT) C57Bl/6 mice signs metabolic dysbiosis (MD) induced use fructose solution or poloxamer 407 (P 407), during treatment combination sodium polyprenylphosphate (PPP) and beta-sitosterol (BSS). Materials Methods. MD in drinking 20 per cent water solution. also by intraperitoneal P at dose 500 mg/kg two times week ten weeks. experimental groups received intragastrically PPP BSS...
Ongoing outbreaks and often rapid spread of infections caused by coronaviruses, influenza, Nipah, Dengue, Marburg, monkeypox, other viruses are a concern for health authorities in most countries. Therefore, the search study new antiviral compounds great demand today. Since almost all with pandemic potential have immunotoxic properties various origins, particular attention is paid to development immunomodulatory drugs. We synthesised compound related indole-3-carboxylic acid derivatives...