A fast adoption of a non-invasive prenatal testing (NIPT) in clinical practice is global tendency last years. Firstly, Russia according new regulation it was possible to perform widescale pregnant women chromosomal abnormality risk. The aim the study-to assess efficiency using NIPT as second-line first trimester screening test Moscow.Based on combined results 12,700 were classified high-risk (cut-off ≥ 1:100) and an intermediate-risk 1:101 - 1:2500) groups followed by whole genome NIPT....

The objective — To assess the effectiveness of including NIPT in structure prenatal diagnostics Moscow. Material and Methods Totally 5,181 pregnancies undergoing screening for fetal trisomy using during period from 01.04.2020 to 30.09.2020 Russia. According results biochemical blood test, patients were divided into two groups: group high risk (cut-off ≥1:100) (n=208) intermediate 1:101 – 1:2500) (n=4,973). Patients at high-risk cell-free DNA (cfDNA) offered an invasive procedure, followed by...

Цель исследования: оценка ресурса г.Москвы в снижении материнской смертности при угрожающих жизни септических осложнениях акушерстве (СОА).Дизайн: ретро-и проспективное многоцентровое когортное исследование

Introduction. Diseases directly related to pregnancy are still leading the maternеal mortality structure, al-though in many countries there is an increase number of deaths from extragenital pathology among pregnant women. A significant lethal cases this group associated with environmental factors, lifestyle, and overall somatic diseases. The aim study was determine main causes maternal investigate role based on autopsy data. Materials methods. included 29 observations. We studied medical...

BACKGROUND: Group B streptococcal infection remains the epicenter of attention for maternal and child health services around world. Premature rupture membranes requires adaptation obstetric tactics intrapartum antibiotic prophylaxis. AIM: The aim this study was to identify risks group streptococcus colonization birth canal lack antepartum screening in cases premature full-term pregnancy. MATERIALS AND METHODS: This retrospective cohort conducted Perinatal Center City Clinical Hospital No. 31...

Teratomas are the most common congenital tumors, and composed of various tissues ectodermal, mesodermal, endodermal origin. Usually, they contain derivatives all three germ layers such as bone, cartilage, muscle, epithelial glandular tissue. Mediastinal teratomas extremely rare, usually arise in anterior mediastinum a median or paramedian mass. In perinatal period, up to 15% observed. The tumor is more often located mediastinum, may be associated with thymus thyroid gland, some cases it not...

Введение. В практике детского эндокринолога для оценки причин и принятия решения о вариантах лечения пациента с истинным преждевременным половым развитием (иППР) существует отработанный алгоритм действий. После исключения объемного образования центральной нервной системы назначают циклическую супрессивную терапию трипторелином. Целью данного исследования было изу чение становления пубертатного периода у девочек после окончания терапии иППР Для достижения цели были поставлены задачи,...

Objective. To analyze the clinical and anamnestic characteristics of patients with aneurysms various localizations during pregnancy to study risk factors for aneurysm rupture. Patients methods. This article presents a retrospective analysis medical obstetric records 100 pregnant postpartum women (44 had without rupture, 18 underwent planned vascular surgery, 38 ruptured aneurysm) arterial normal labor (control group). The groups were compared by age, body mass index, height, smoking status,...

Relevance. At the present time, despite large number of studies, root causes pre-eclampsia remain unknown. In recent years, attention is paid to study role vascular growth factors in pathogenesis various obstetric pathologies, including pre-eclampsia. The aim our was examine features angiogenic imbalance determining severity pre-eclampsia, and further tactics conducting pregnant women. Matherials Methods. 135 women were examined: I group - 50 with preeclampsia moderate; II 36...

Prevention of postpartum haemorrhage is one the important tasks modern obstetrics, anesthesiology and intensive care. Objective. To assess efficacy safety terlipressin usage as a means development prevention during caesarean section in high-risk pregnant women. Patients methods. From February to December 2020, multicenter comprehensive cohort study, which 5 medical centers participated, was conducted. The study included 454 women who underwent were divided into two groups: control group I (n...

Severe and massive bleeding remains one of the main causes maternal mortality morbidity. The use terlipressin has proved to be effective in prevention postpartum haemorrhage high-risk group. Given that is a potent vasopressor, there are concerns about its parturient women with hypertension. Objective. To evaluate hemodynamic effects when it injected into myometrium during caesarean section. Patients methods. This publication continuation research work on effectiveness pregnant women, which...

Introduction. Diseases that are not directly related to obstetric pathology and childbirth fade into the back-ground always included in maternal mortality, but their significance can hardly be overes-timated. A special group of such pathologies comprises infectious diseases, prevalence which varies significantly different countries. As a rule, these diseases characterized by severe course life-threatening for mother child. The most relevant among them HIV infection, tuberculosis,...

Objective. To study the main causes of maternal mortality and to determine role obstetrical pathologies based on findings pathoanatomical autopsies. Materials methods. The included 42 autopsy findings, we studied medical documentation, records deceased pregnant parturient women. most common (n = 29), according latest revision ICD-10, were analyzed in detail. general clinical morphological examination was performed. Results. In Moscow, more than half cases structure refer pathologies....

Congenital malformations, chromosomal and monogenic disease play a significant role in perinatal mortality child disability. According to the early prenatal screening results Russian Federation 2018, overall ratio of anomaly prevalence is 1:250–1:300. Currently aneuploidy risk calculated by using indirect biochemical ultrasound markers, that have low sensitivity specificity which can cause false positives negative leading unreasonable invasive procedures or missing anomalies. It well known...

<h3></h3> В статье проведена оценка реализации пациенториентированных принципов в акушерской практике на примере проекта «Роды Москве», даны рекомендации по его совершенствованию и масштабированию. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Оценить возможности помощи региональном уровне, разработать повышению доступности удовлетворенности пациенток ее качеством. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Данное наблюдательное, несравнительное, проспективное, продолжительное многоцентровое исследование посвящено изучению...

Non-invasive prenatal testinging (NIPT) is a relatively new method aimed at detecting fetal chromosomal aneuploidies by analyzing extracellular fetoplacental DNA in the blood of pregnant woman. NIPT has high sensitivity and specificity, many professional communities now recommend its use as screening method. Since introduction into clinical practice Hong Kong 2011, expanded rapidly around world. The experience various countries organizing non-invasive testing described this article. Key...

During pregnancy the effects of a number predisposing factors (influence progesterone, violation passage urine, occurrence vesicoureteral reflux) often lead to exacerbation chronic diseases urinary tract, development eye and preeclampsia. This has an adverse impact on course perinatal outcomes. The Multicenter study «Evaluation efficacy, safety tolerability cranberry extract in soft capsules Iuravit (biologically active additive food) for prophylaxis complex therapy tract infections women...

For several decades, among all possible pathogens of neonatal infections, group B streptococcus has been one the leading positions. Sepsis, meningitis, and pneumonia are most common clinical manifestations infection associated with streptococcus. In this review, our goal was to analyze literature demonstrating a worldwide approach prevention vertical transmission from mother child. When writing scientific publications foreign domestic authors PubMed database were studied. The review...