A5084484461- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Inflammatory Bowel Disease
- Pelvic floor disorders treatments
- Microscopic Colitis
- Colorectal Cancer Surgical Treatments
- Congenital gastrointestinal and neural anomalies
- Autoimmune and Inflammatory Disorders
- Soft tissue tumor case studies
- Surgical site infection prevention
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Neurofibromatosis and Schwannoma Cases
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Clostridium difficile and Clostridium perfringens research
- Colorectal and Anal Carcinomas
State Scientific Center of Coloproctology
2016-2025
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AIM: to develop methods of conservative treatment proctological patients based on pelvic floor muscles (PFM) neurophysiology.PATIENTS AND METHODS: thirty-seven with pudendal neuropathy manifested by anal incontinence (AI) and/or obstructive defecation neurogenic pain (and their combination) included in the prospective cohort study. There were 5 (13.5%) proctogenic constipation as main complaint, 12 (32.4%) AI, 14 (37.9%) pain; 6 (16.2%) combined disorders. 22 (59.5%) women, 15 (40.5%) men,...
AIM: to compare the efficacy (fistulas healing rate) and safety (morbidity of mesenchymal stem cells (MSC) placebo in patients with perianal fistulizing Crohn’s disease (PFCD). PATIENTS AND METHODS: a systematic review meta-analysis clinical trials, comparing results treatment PFCD single local administration MSCs or was performed. The included 5 randomized trials 289 were analyzed. RESULTS: demonstrates high for compared (OR = 2.10, CI 1.28–3.46, p 0.003). most common postoperative...
Treatment of аnal fistulas as perianal manifestations Crohn’s disease is an important task, the solution which has not yet been found. First all, this due to debilitating symptoms that reduce quality life. Incorrect tactics in treatment can lead development anal incontinence, and some cases removal rectum. The purpose review was study effectiveness various surgical methods for fistulas, features their use types well assess impact on function sphincter. It found most described were used a...
AIM: to evaluate the results of treatment chronic anal fissure in combination with grade 3–4 hemorrhoids. PATIENTS AND METHODS: prospective randomized study included 94 patients hemorrhoids, which had two groups. Forty-eight main group underwent controlled circular dilation (CCD) and 46 control lateral subcutaneous sphincterotomy (BPS). In both groups, patient excision surgical RESULTS: postoperative pain CCD was significantly lower than BPS during all 7 days after surgery (p = 0.0085; p...
AIM: to assess early and late results of the evagination method for treatment rectovaginal fistulas (RVF) in patients with anal incontinence due muscle defect anterior semicircle. PATIENTS AND METHODS: study included 45 patients. The prevailing etiology RVF was delivery lesion 19/45(42.2 %). median follow-up 6 (4; 8.5) months. On day 30 after surgery, outcome assessed clinically. Late outcomes were all 3–12 months including clinical control, transanal ultrasound sphincterometry. RESULTS:...
Schwannoma (also known as neurilemmoma) is a type of benign tumor that originates from the myelin sheath around peripheral nerves. It composed schwann cells, which are specialized cells help to insulate nerve fibers. Schwannomas relatively rare, accounting for only 5% all tumors in perineal region. They usually asymptomatic and detected when they come into contact with other organs or structures, causing symptoms such compression. Preoperative diagnosis schwannoma challenging, it often...
The review evaluates pathogenesis of intestinal fistulas in Crohn’s disease (CD). An idea the possible contribution microbiological and genetic factor is given. effect matrix metalloproteinases their tissue inhibitors also assessed. One most promising areas which can explain development CD epithelial-mesenchymal transition. Further research required to identify cause complicated CD, future will develop correct approaches pathogenetic therapy.
AIM : to evaluate the effect of intestinal anastomosis type on risk Crohn’s disease (CD) recurrence. PATIENTS AND METHODS: retrospective cohort study included 130 patients with CD who underwent surgery for a complicated in 2012–2017. Ileocecal resection was performed 112/130 (86.2%) patients. Resection terminal ileum right side colon formation an ileo-transverse anastomosis. In 18/130 (13.2%) cases. Stapled “side-to-side” formed 57/130 (43.8%) patients, while hand sewn “end-to-end” — 73/130...
Background. The intestinal microbiota, on the one hand, protects a person from pathogens, other it itself may be of triggers and/or mediators progression in inflammatory bowel diseases. Inflammatory disease (IBD) predominantly affects young people working age. It noted steady increase incidence IBD recent decades throughout world and Russia. diseases significantly affect quality life lead to complications having perform surgery, which reduces life. Aims study was investigate composition...
AIM. Ligation of intersphinctericfistllа tract (LIFT) is a new sphincter-preserving technique avoiding development anal incontinence. The aim the study evaluation effectiveness this procedure. METHOD. From Jan 2013 to Dec 2015 40 patients with fistulae, exciting more than 30% sphincter was included in study. Male: 28 (70%), Female: 12 (30%). 29 (72,5%) cases were middle transsphincteric, 16 (22,5%) - deep transsphincteric and 2 (5%) suprasphincteric. RESULTS. median follow up months ((3-36)...
The main link in the pathogenesis of anal fissure is a spasm internal sphincter rectum, connection with which many methods muscle relaxation have been developed. A special place occupied by dilatation methods, are quite diverse. To assess their effectiveness and safety, authors carried out systematic review meta-analysis 9 selected randomized clinical trials comparing results treatment chronic using traditionally used method lateral subcutaneous sphincterotomy. 716 patients were analyzed an...
The article presents a comparative analysis of the small intestine strictureplasty and resection method for treatment patients with Crohn's stricture. results obtained showed absence any statistically significant differences between two methods surgical treatment. Thus, we can confidently speak about safety in complicated form disease.
The article presents an analysis of the sensitivity and specificity CT enterography ultrasound elastography in diagnosis a fibrous process intestinal wall patients with Crohn's stricture. results obtained showed very good quality detection changes using enterography, while US demonstrated unsatisfactory method used.
AIM: to evaluate microbiota of anal fistulas. The discharge fistula track was taken in 54 patients with transsphincter fistulas before surgery. microbiology carried out using an extended range culture medium incubation aerobic, anaerobic and microaerophilic environment extract the maximum possible number microbes. One hundred sixty strains microbes have been isolated cases: gram positive bacteria — 109 (68.4 %) cases gram-negative 49 (30.4 %). Yeast fungi were detected 2 (1.2 cases....
3D ЭНДОРЕКТАЛЬНАЯ УЛЬТРАЗВУКОВАЯ ДИАГНОСТИКА ПРЯМОКИШЕЧНЫХ СВИЩЕЙ КРИПТОГЕННОГО ПРОИСХОЖДЕНИЯ С ОТСУТСТВУЮЩИМ ИЛИ ОБЛИТЕРИРОВАННЫМ НАРУЖНЫМ СВИЩЕВЫМ ОТВЕРСТИЕМ