A5017380068- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Esophageal and GI Pathology
- Diet and metabolism studies
- Gastroesophageal reflux and treatments
- Abdominal vascular conditions and treatments
- Body Contouring and Surgery
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- Abdominal Surgery and Complications
- Obesity and Health Practices
- Extracellular vesicles in disease
- Omental and Epiploic Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Hernia repair and management
- Obesity, Physical Activity, Diet
- Eosinophilic Esophagitis
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Pelvic and Acetabular Injuries
- Eating Disorders and Behaviors
- Dysphagia Assessment and Management
- Peroxisome Proliferator-Activated Receptors
First Pavlov State Medical University of St. Petersburg
2018-2025
Leningrad Regional Cancer Center
2018
Obesity remains one of the global problems modern healthcare. Complications after bariatric surgery are a serious problem for this group patients. This article reflects results Second Consensus Conference, held on May 25, 2024 in St. Petersburg and fully devoted to treatment complications 99 surgeons participated consensus. was considered achieved when 70% respondents agreed. The consensus determines algorithm actions development patient will allow who do not have specialized training...
Aim : to present the results of an Expert Consensus on standardization indications for surgical treatment gastroesophageal reflux disease (GERD). Materials and methods . The issues GERD were discussed by 39 experts – leading gastroenterologists surgeons from 7 cities Russia, representing 17 institutions. list questions discussion was formed initiative group sent experts. reviewed recent literature, including existing clinical guidelines consensuses, assessed evidence base suggested...
Extracellular vesicles (EVs) are cell-derived membrane which play an important role in cell-to-cell communication and physiology. EVs deliver biological information from producing to recipient cells by transport of different cargo such as proteins, mRNAs, microRNAs, non-coding RNAs lipids. Adipose tissue could regulate metabolic inflammatory interactions inside adipose depots well distal tissues. Thus, assumed be implicated obesity-associated pathologies, notably insulin resistance type 2...
Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Adipose tissue (AT) extracellular vesicles (EVs) could play role in obesity T2DM associated CVD progression via the influence of their specific cargo on gene expression recipient cells. The aim this work was to evaluate effects AT EVs patients with with/without reverse cholesterol transport (RCT)-related human monocyte-derived macrophages (MDMs) from healthy donors. were obtained after ex vivo...
Obesity is a significant risk factor for the development of type 2 diabetes mellitus (T2DM). Adipose tissue dysfunction can affect pool circulating exosomal miRNAs, driving concomitant disease in obesity. These miRNAs reflect adipose functionality, thus serving as prognostic biomarkers monitoring case T2DM. In present study, we conducted NanoString microRNA profiling extracellular vesicles (EVs) secreted by obese patients (body mass index (BMI) > 35) without T2DM and nonobese individuals...
Currently, bariatric (metabolic) surgery is the main effective treatment of obesity and associated pathological conditions. The features course as a chronic progressive disease, heterogeneous etiology, clinical manifestations steady increase in number patients worldwide make problem interventions extremely urgent. article presents analysis modern data concerning choice method surgical benefits with their own experience.
Type 2 diabetes prevalence is increasing dramatically worldwide. Conservative therapy doesn’t bring stable effect and often insufficient, not to mention the lack of prospects cure disease. Fortunately, accumulating evidence points towards notion that a complete remission type feasible following choice surgical interventions. The efficacy bariatric surgery in particular for achieving glycemic control has highlighted as candidate curative intervention diabetes. When compared intensive medical...
The OBJECTIVE was to improve the results of surgical treatment morbid obesity by reducing frequency postoperative complications. METHODS AND MATERIALS. research is based on studying 149 morbidly obese patients. patients were divided into retrospective (49 patients) and prospective (100 groups. RESULTS. Among group (n=49), a statistical analysis effectiveness using various scales indices for predicting risk complications bariatric interventions carried out. revealed low efficiency currently...
The relevance of the problem obesity is due to progressive increase in morbidity worldwide and high risk developing pathological conditions associated with overweight. development cardiovascular diseases, lipid metabolism disorders, type 2 diabetes mellitus greatest importance. Among various types treatment for morbid obesity, bariatric surgery occupies a leading position acquires special role correction excess body weight its metabolic efficiency. A clinical case surgical middle-aged woman...
The article presents the experience of using a composite mesh prosthesis for herniology Proceed (Johnson & Johnson). technique this material during healing 12 patients with giant median ventral and lateral parastomal hernias is described. immediate long-term (over period five to nine years) results treatment patients.
OBJECTIVE. Hiatal hernias are the most common type of visceral anatomy disorder. The unresolved problem surgical treatment this pathology remains high frequency its relapse. Currently, it is believed that repeated interventions for hiatal hernia technically difficult, carry a risk complications and have unsatisfactory long-term results. MATERIAL AND METHODS. In period from 2015 to 2019, 55 patients with were operated. 52 (94.5 %) cases, revision operation was performed laparoscopically, in 3...
Celiac trunk compression syndrome is a symptom complex arising from of the celiac by median arcuate ligament, crura diaphragm or ganglion tissue plexus. The main clinical manifestations this pathological condition are abdominal pain syndrome, indigestion and weight loss. disease detected in 0.4–1 % people population, more often young people. pathophysiological mechanisms development remain not fully understood, but key reason for its ischemia digestive system. instrumental methods diagnosing...
Identification of patients with obstructive sleep apnea syndrome and high respiratory risk, optimization the screening algorithm for these administration preventive non-invasive lung ventilation, makes it possible to prevent development perioperative complications, reduce duration hospital stay mortality in undergoing surgery bariatric specifically. The objective : evaluate effectiveness STOP-BANG questionnaire targeted therapy risk complications patients. Subjects Methods. We examined 60...
The objective was to improve the efficiency and safety of surgical treatment in elderly patients with morbid obesity. Methods materials . study included 20 obesity aged 60 69 years. following scores indices were used assess comorbidity risk complications from surgery: OS-MRS, Charlson index, Caprini score, HAS-BLED score. Results course postoperative period smooth 17 (85 %) people did not differ that middle-aged patients, subject careful preoperative examination preparation. factors initial...
This original article discusses the main concomitant diseases and psychological problems of patients with morbid obesity seeking help from bariatric (metabolic) surgeons. The study was conducted on basis St. Petersburg State Medical University n. a. I. P. Pavlov, it most voluminous laboratory-instrumental examination, which a peculiar portrait Russian patient compiled. Gastroenterological symptoms were predominant in obesity. Heartburn common complaint. Non-erosive reflux disease diagnosed...
The OBJECTIVE was to increase the safety of laparoscopic decompression abdominal trunk. METHODS AND MATERIALS. results treatment 30 patients who underwent celiac trunk were analyzed. Intraoperative bleeding requiring conversion laparotomy occurred in two (6.7%) cases. RESULTS. To prevent such a complication, method preventive installation balloon catheter into introduced, which allows creating temporary occlusion vessel case damage. A similar approach used 10 (33.3%) patients. need cover...
The article presents clinical case surgical treatment of obesity in the patient with Prader-Willy-Labhart syndrome (PWS). had characteristic phenotypic features disease: low growth, narrow temporal part skull, dolichocephaly, acromicria. There was a delay psychomotor development, hypogonadism. Excess body weight noted from three years old gradual progression obesity. Now is 23 and her 159 kg an increase 150 cm (BMI 70.7 kg/m2). co-morbidities were represented by arterial hypertension, type 2...
Introduction. Surgical treatment of obese patients includes a high risk complications. Material and methods. The article presents the analysis informativeness reliability OS-MRS, E. Livingston, P. Turner scores in predicting postoperative complications with overweight metabolic disorders. Results. According to study, OS-MRS score was most reliable.
Recurrent hiatal hernia is the re-displacement of abdominal organs into chest after surgical treatment. Indications for repeated interventions this pathology are resistant to medical correction gastroesophageal reflux or anatomical disorders, bearing risk developing life-threatening conditions. The key task revision identify and address causes failure primary operation. main factors recurrence hernias localization large size opening, mechanical weakness legs diaphragm shortening esophagus....
Hiatal hernias are the most common violation of visceral anatomy. Indications for surgical treatment this pathology include refractory gastroesophageal reflux or anatomical changes, which carry a risk developing life-threatening conditions. An unresolved problem in area surgery is high recurrence rate disease, reaching 1040%. Subjective causes unsatisfactory results technical errors performing interventions and violations perioperative management. Compliance with methodology operations rules...
Introduction . Obesity is associated with a high risk of developing concomitant diseases such as: metabolic syndrome, type 2 diabetes mellitus (DM2), cardiovascular pathology. FABP4 (fatty acid binding protein) the specific lipid chaperone and an important protein for function adipose tissue one adipocytokines secreted by tissue. The objective study was to investigate gene expression in subcutaneous visceral (SAT VAT) patients obesity DM2. Methods materials SAT VAT samples were obtained...
The OBJECTIVE was to study the efficacy and safety of laparoscopic decompression celiac trunk. METHODS AND MATERIALS. A comparative analysis results (30 patients) conventional trunk (50 carried out. All patients were operated on between September 2018 July 2021. RESULTS. Intraoperative bleeding during trunk, which required conversion access laparotomy vascular suture, noted in 2 (6.7 %) cases. With access, there no such complications. average duration 107 minutes, from – 150 minutes. length...
Introduction . Currently, traditional methods and minimally invasive surgical technologies are used in the treatment of celiac trunk compression syndrome. The choice method remains a subject discussion. drawback classical approach – laparotomy is significant trauma to tissues abdominal wall, risk adhesions, wound infection hernias. disadvantage videosurgical techniques developing life-threatening bleeding requiring conversion access. main cause this complication damage wall aorta, its...