Extracellular vesicles (EVs) are cell-derived membrane which play an important role in cell-to-cell communication and physiology. EVs deliver biological information from producing to recipient cells by transport of different cargo such as proteins, mRNAs, microRNAs, non-coding RNAs lipids. Adipose tissue could regulate metabolic inflammatory interactions inside adipose depots well distal tissues. Thus, assumed be implicated obesity-associated pathologies, notably insulin resistance type 2...

Obesity is a significant risk factor for the development of type 2 diabetes mellitus (T2DM). Adipose tissue dysfunction can affect pool circulating exosomal miRNAs, driving concomitant disease in obesity. These miRNAs reflect adipose functionality, thus serving as prognostic biomarkers monitoring case T2DM. In present study, we conducted NanoString microRNA profiling extracellular vesicles (EVs) secreted by obese patients (body mass index (BMI) > 35) without T2DM and nonobese individuals...

Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Adipose tissue (AT) extracellular vesicles (EVs) could play role in obesity T2DM associated CVD progression via the influence of their specific cargo on gene expression recipient cells. The aim this work was to evaluate effects AT EVs patients with with/without reverse cholesterol transport (RCT)-related human monocyte-derived macrophages (MDMs) from healthy donors. were obtained after ex vivo...

The article presents the problem of development complications bariatric surgery in early postoperative period. After start use endovideosurgical technologies surgery, incidence general surgical period dropped sharply to 2-6 %. Nevertheless, serious still arise, frequency and type which largely depends on patient's comorbidity complexity operation. most formidable difficult complication treatment is failure sutures stomach stump (stapler line), more often characteristic longitudinal resection...

Currently, bariatric (metabolic) surgery is the main effective treatment of obesity and associated pathological conditions. The features course as a chronic progressive disease, heterogeneous etiology, clinical manifestations steady increase in number patients worldwide make problem interventions extremely urgent. article presents analysis modern data concerning choice method surgical benefits with their own experience.

Gastric leak is the most dangerous postoperative complication of laparoscopic sleeve gastrectomy. Traditional surgical treatment options and endoscopic stent placement are not always successful. Negative Pressure Wound Therapy (NPWT) has shown itself like a new successful feasible option for leaks different etiology after gastro-esophageal surgery. The initial body mass index (BMI) patient was 46 co-morbidity represented: arterial hypertension, type 2 diabetes dyslipidemia. NPWT initiated in...

The OBJECTIVE was to improve the results of surgical treatment morbid obesity by reducing frequency postoperative complications. METHODS AND MATERIALS. research is based on studying 149 morbidly obese patients. patients were divided into retrospective (49 patients) and prospective (100 groups. RESULTS. Among group (n=49), a statistical analysis effectiveness using various scales indices for predicting risk complications bariatric interventions carried out. revealed low efficiency currently...

The relevance of the problem obesity is due to progressive increase in morbidity worldwide and high risk developing pathological conditions associated with overweight. development cardiovascular diseases, lipid metabolism disorders, type 2 diabetes mellitus greatest importance. Among various types treatment for morbid obesity, bariatric surgery occupies a leading position acquires special role correction excess body weight its metabolic efficiency. A clinical case surgical middle-aged woman...

The article presents the main stages of development ideas about a fairly rare pathology in clinical practice syndrome compression ventral trunk. Until mid-nineteenth century, reports picture chronic abdominal ischemia were more descriptive. Serial pathoanatomic studies, comparison anatomical features revealed at autopsy with manifestations accompanying these changes, contributed to isolation ischemic disease digestive system separate nosological form. discovery angiography significant...

Celiac trunk compression syndrome is a symptom complex arising from of the celiac by median arcuate ligament, crura diaphragm or ganglion tissue plexus. The main clinical manifestations this pathological condition are abdominal pain syndrome, indigestion and weight loss. disease detected in 0.4–1 % people population, more often young people. pathophysiological mechanisms development remain not fully understood, but key reason for its ischemia digestive system. instrumental methods diagnosing...

The celiac trunk compression syndrome and the gastroesophageal reflux disease are quite common pathological conditions in population of economically developed countries. frequency combining semiotics these illness has not been studied. There no approaches to diagnosis treatment disease, which on background chronic ischemia abdominal cavity organs due occlusion trunk. Few papers devoted this subject limited a small series clinical observations without detailed understanding problem finding...

Relevance. Clarifying the sequence and mutual connection of median arcuate ligamentum syndrome (MALS) reflux esophagitis (RE) makes it possible to determine indications success operation. The objective study was compare results examination operations in patients with MALS combination RE. Material methods. 198 were examined operated. Among them, 85 just MALS, decompression celiac trunk performed for them. 84 had RE, simultaneously Nissen fundoplication that group patients. 29 only group. A...

The article discusses modern methods of treatment morbid obesity and associated diseases. It is known that leads to disability in people, including young due the frequent development severe comorbid According current clinical guidelines, main goals treating obese patients are: weight loss, achieving good metabolic control, improving course diseases with obesity. A small selection drugs for obesity, need strict adherence indications contraindications their appointment, significantly limits...

Identification of patients with obstructive sleep apnea syndrome and high respiratory risk, optimization the screening algorithm for these administration preventive non-invasive lung ventilation, makes it possible to prevent development perioperative complications, reduce duration hospital stay mortality in undergoing surgery bariatric specifically. The objective : evaluate effectiveness STOP-BANG questionnaire targeted therapy risk complications patients. Subjects Methods. We examined 60...

The objective was to improve the efficiency and safety of surgical treatment in elderly patients with morbid obesity. Methods materials . study included 20 obesity aged 60 69 years. following scores indices were used assess comorbidity risk complications from surgery: OS-MRS, Charlson index, Caprini score, HAS-BLED score. Results course postoperative period smooth 17 (85 %) people did not differ that middle-aged patients, subject careful preoperative examination preparation. factors initial...

Introduction. Nowadays, obesity is considered as a chronic metabolic disease that occurs at any age. The relevance of the study defined by high prevalence obese people objective was psychological assessment level compliance, emotional state, characteristics eating behavior and satisfaction with quality life in patients morbid before after bariatric surgery. Methods materials. included 30 who underwent surgery aged 26 to 53 years. Psychodiagnostic techniques clinical scales were used...

This original article discusses the main concomitant diseases and psychological problems of patients with morbid obesity seeking help from bariatric (metabolic) surgeons. The study was conducted on basis St. Petersburg State Medical University n. a. I. P. Pavlov, it most voluminous laboratory-instrumental examination, which a peculiar portrait Russian patient compiled. Gastroenterological symptoms were predominant in obesity. Heartburn common complaint. Non-erosive reflux disease diagnosed...

The OBJECTIVE was to increase the safety of laparoscopic decompression abdominal trunk. METHODS AND MATERIALS. results treatment 30 patients who underwent celiac trunk were analyzed. Intraoperative bleeding requiring conversion laparotomy occurred in two (6.7%) cases. RESULTS. To prevent such a complication, method preventive installation balloon catheter into introduced, which allows creating temporary occlusion vessel case damage. A similar approach used 10 (33.3%) patients. need cover...

ЦЕЛЬ: улучшение результатов хирургического лечения пациентов с морбидным ожирением.
 МАТЕРИАЛЫ И МЕТОДЫ: в исследование включены результаты 240 паци-
 ентов ожирением, находившихся на лечении Центре ожирения
 и метаболических нарушений 2017 года по 2022.
 Мультидисциплинарной командой врачей, был разработан алгоритм предоперационного обследования
 отбора метаболические операции, включающий себя не только лабораторные инстру-
 ментальные методы исследования, но...