A5088495651- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Function and Risk Factors
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Parathyroid Disorders and Treatments
- Heart Failure Treatment and Management
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
- Cancer Treatment and Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Biomarkers in Disease Mechanisms
- Pancreatitis Pathology and Treatment
- Atrial Fibrillation Management and Outcomes
- Diet, Metabolism, and Disease
- Healthcare Systems and Public Health
- Liver Diseases and Immunity
- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- SARS-CoV-2 and COVID-19 Research
Pirogov Russian National Research Medical University
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Kabardino-Balkarian State University
2024
European Society of Cardiology
2024
Associazione Nazionale Medici Cardiologi Ospedalieri
2024
Moscow Power Engineering Institute
2023
British Heart Foundation
2022
National Rehabilitation Center
2020-2022
University of Leeds
2022
Royal Rehabilitation Centre
2020
The phase IIb, double-blind, placebo-controlled PILLAR trial investigated the efficacy and safety of two different simeprevir (SMV) doses administered once-daily (QD) with pegylated interferon (Peg-IFN)-α-2a ribavirin (RBV) in treatment-naïve patients HCV genotype 1 infection. Patients were randomized to one five treatments: SMV (75 or 150 mg QD) for 12 24 weeks placebo, plus Peg-IFN RBV. arms stopped all treatment at week if response-guided therapy (RGT) criteria met; not meeting RGT...
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Aim: present clinical guidelines, aimed at general practitioners, gastroenterologists, cardiologists, endocrinologists, comprise up-to-date methods of diagnosis and treatment non-alcoholic fatty liver disease. Key points. Nonalcoholic disease, the most wide-spread chronic is characterized by accumulation fat more than 5 % hepatocytes presented two histological forms: steatosis nonalcoholic steatohepatitis. Clinical guidelines provide current views on pathogenesis disease as a multisystem...
The National Consensus was prepared with the participation of Medical Association for Study Multimorbidity, Russian Scientific Liver Society, Endocrinologists, Gerontologists and Geriatricians, Society Preventive Cardiology, Professional Foundation Promotion Medicine Fund PROFMEDFORUM. aim multidisciplinary consensus is a detailed analysis course non-alcoholic fatty liver disease (NAFLD) main associated conditions. definition NAFLD given, its prevalence described, methods diagnosing...
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Aim. Clinical guidelines for the management of adult patients suffering from drug-induced liver injuries (DILI) are intended all medical specialists, who treat such in their clinical practice. Key findings. The presented recommendations contain information about epidemiological data, terminology, diagnostic principles, classification, prognosis and with DILI. list pharmacological agents that most commonly cause DILI, including its fatal cases. Dose-dependent predictable (hepatotoxic), as...
Heart failure is an important medical, social and economic problem around the world. In recent years, a number of diagnostic prognostic biological markers blood in cardiovascular diseases have been studied. Identification new markers, analysis their pathophysiological aspects changes concentration under influence various treatment options, allow us to understand many pathogenetic features development course heart failure. decades, natriuretic peptides introduced into clinical practice, which...
Heart failure (HF) is an important medical, social and economic problem. The study of new biological markers deepens our understanding the pathogenesis this disease. In modern cardiology, there a growing interest in matrix metalloproteinases (MMPs). These enzymes play role tissue remodeling, angiogenesis, as well cell proliferation, migration differentiation. purpose literature review to analyze current experimental clinical data on MMP-9 diagnostic prognostic marker HF. This presents...
Cardiovascular diseases (CVD) represent a global medical, social, and economic issue. Currently, the search study of new biological markers that can provide early diagnosis CVD, serve as laboratory tools for assessing effectiveness treatment, or be used prognostic risk stratification criteria are ongoing. Scientists particularly interested in studying chitinase-3-like protein 1 (CHI3L1, YKL-40) relation to CVD. The precise role CHI3L1 both normal pathological conditions remains unclear....
Osteoporosis is a multifactorial disease and often associated with sarcopenia. Their combination may be an additional risk factor for these patients. Malnutrition both conditions. It increased mortality, disability, cognitive decline, incidence of falls fractures. Nutritional support patients provide benefits in prevention treatment. The article discusses current data on the role nutrition complex therapy osteoporosis accompanying syndromes.
To review the results of open observational study Makhaon on use a fixed combination glycyrrhizic acid (GA) and ursodeoxycholic (UDCA) (Phosphogliv Urso) for treatment abdominal pain, assessment contractile function gallbladder bile rheology in patients with stage I cholelithiasis. The included 330 subjects, 44.5% males 55.5% females. participants were 18-70 years old, mean age 43.8±0.6 years. In 2021-2022, treated 14 clinical centers 10 cities Russian Federation: Moscow, St. Petersburg,...
Celiac disease (CD) is a systemic autoimmune disorder caused by gluten intolerance, often remaining undiagnosed due to its oligosymptomatic presentation. Data on the prevalence of CD and association with other gastrointestinal conditions in men conscription age are limited. Objective: To evaluate prevalence, clinical, serological characteristics celiac aged 18—27. Materials Methods. Between 2017 2023, 5.670 conscription-age were assessed at Buyanov City Clinical Hospital. The study combined...
Aim . The clinical guidelines are intended to provide information support for making decisions by gastroenterologists, general practitioners and internists that will improve the quality of medical care patients with non-alcoholic fatty liver disease, taking into account latest data principles evidence-based medicine. Key points Clinical contain about current views on etiology, risk factors pathogenesis nonalcoholic peculiarities its course. Also given recommendations methods laboratory...
Тakotsubo cardiomyopathy is characterized by transient cardiac contractility disorders, mainly in the left ventricle, that occur under stress and other adverse conditions. The clinical picture resembles acute myocardial infarction with intact coronary arteries, resolves completely over time. treatment nonspecific. Along this, prevention of thromboembolic complications, arrhythmia, heart failure great importance. case a 78-year-old patient hospitalized complaints burning precordialgia...
An observation of a patient hospitalized for sigmoid diverticulitis, complicated by abscess formation and requiring non-trivial study cardiological comorbidity, the etiology which was not mentioned in available medical documentation, has been presented. Retrospective analysis anamnestic, laboratory instrumental data showed that aortic valve disease had previously undergone prosthesis with mechanical valve, dilation aorta were result prior visceral syphilis. Neurological symptoms to greatest...
The combination of heart failure and renal is called cardiorenal syndrome. It a stage the continuum and, possibly, small link cardiorenal-cerebral-metabolic axis. Despite fact that phrase “cardiorenal syndrome” its five types have become part medical lexicon, many aspects this problem are still not clear. Cardiorenal syndrome can be diagnosed in 32-90.3% patients with failure. type 1 or 2 develops most cases failure: presents development ofchronic kidney disease chronic acute injury Impaired...
Biomarkers (various laboratory biochemical markers), such as natriuretic peptides (NP), soluble ST2 receptor, copeptin, galectin-3, are widely studied in patients with chronic heart failure (CHF). The European Society of Cardiology recommends the determination blood NP level suspicion HF and its use one mandatory diagnostic criteria for CHF preserved mid-range ejection fraction. Dynamics concentration may be predictor effectiveness therapy necessity titration dose drugs. Neprilyzin destroys...
An outbreak of unknown pneumonia, caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), was reported in China at end December 2019. On February 11, 2020, World Health Organization officially named SARS-CoV-2 infection COVID-19 (Coronavirus Disease 2019). The most common clinical manifestation is pneumonia. However, with spread pandemic and analysis data, symptoms that are not characteristic "atypical" pneumonia have been identified patients. Neurological symptoms,...
Cardiac amyloidosis (amyloid cardiomyopathy) is a disease damage to the heart caused by extracellular amyloid deposition. In some cases, there may be local structures of heart, for example, atria; more often, part systemic (generalized) pathology. Depending on precursor protein, 36 types are described, among which hereditary and acquired forms distinguished. diagnosed 1) in case infiltration myocardial bioptates or 2) non-cardiac deposition left ventricular wall thickening >12 mm without...
High efficacy of contemporary chemical and radiation treatments made it to success in treatment oncohematological diseases. The fundamentals many schemes polychemotherapy the first line are anthracyclines. Effective main disease cases is followed by a variety cardiovascular complications, including severe ones fatal. It necessary consider possibility not only for development acute cardiotoxicity, but various complications from system after cessation antitumor treatment. Algorithm patients...