A5017512144- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Lipid metabolism and disorders
- Ultrasound and Hyperthermia Applications
- Eosinophilic Esophagitis
- Drug-Induced Hepatotoxicity and Protection
- Trace Elements in Health
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Metabolism, Diabetes, and Cancer
- Veterinary medicine and infectious diseases
- Clinical Nutrition and Gastroenterology
- Galectins and Cancer Biology
Sechenov University
2015-2024
Regional Clinical Research
2018-2024
Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky
2016-2024
Moscow State University
2021-2024
Development Fund
2021
Ministry of Health of the Russian Federation
2019
Consultative and Diagnostic Center
2016
Innovative Research (United States)
2016
Moscow Regional Research Institute of Obstetrics and Gynecology
2016
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Introduction. In cirrhotic patients, hyperammonemia develops due to impaired ammonia detoxification and portosystemic blood shunting is most commonly associated with hepatic encephalopathy sarcopenia. Currently, there are questions regarding the diagnosis of effect ammonia-lowering therapy on disease outcomes. Materials methods. The Russian Scientific Liver Society selected a panel seven experts in liver cirrhosis research management patients this make reasoned statements recommendations...
The human body, like any other, is an intermediate component of the nitrogen cycle in nature. Consuming from external environment form various compounds, body processes it into ammonia - one final products exchange nitrogen-containing substances [1], which removed urea. most active producers are organs with high amino acids and biogenic amines nerve tissue, liver, intestine, muscles. In a state equilibrium, adult consumes releases about 15 g per day, temporary or permanent disruption balance...
Justification Given the large number of reports on peculiarities liver lesions during Sars-Cov-2 infection [1], a team experts who participated in 23rd Congress Scientific Society Gastroenterologists Russia and 15 National Therapists November 19, 2020 decided to make additions Russian Consensus “Hyperammonemia Adults” published early [2, 3].
It is generally agreed that nonalcoholic fatty liver disease (NAFLD) a component of metabolic syndrome and frequently associated with obesity, type 2 diabetes mellitus, atherogenic dyslipidemia, other components the syndrome. However, there no doubt not all overweight people develop NAFLD and, conversely, latter may be present in normal weight individuals. The prevalence without obesity different countries very variable from 3 to 30%. Its risk factors are considered both exogenous (for...
The majority of deaths related to complications liver cirrhosis would have been preventable with timely diagnosis and proper treatment. However, absence the population-based screening programs for hepatitis, an asymptomatic course disorders, failures in registration etiologically confirmed cases cirrhosis, low population awareness its risks current diagnostic management opportunities do impede collection reliable epidemiological data on incidence prevalence disorders including their...
The article is published based on the results of Russian Consensus diagnosis and treatment primary sclerosing cholangitis (PSC), discussed at 44th annual Scientific Session CNIIG "Personalized Medicine in Era Standards" (March 1, 2018). aim review to highlight current issues classification patients with PSC, which causes greatest interest specialists. urgency problem determined by multivariate nature clinical manifestations, often asymptomatic flow, severe prognosis, complexity insufficient...
Rationale: At present, the metabolic syndrome and pathophysiology of non-alcoholic fatty liver disease, as well identification factors that may influence rate development dystrophy fibrosis in are focus investigators' attention. This study represents an attempt to detail derangements tissue abnormalities after cholecystectomy patients with at baseline. Aim: To performed younger age on course women. Materials methods: was a retrospective analytical sample 57 female (International Diabetes...
Aim: to analyze the data that has so far been accumulated on pathogenetic association of gallstone disease (GD) and non-alcoholic fatty liver (NAFLD), as well assess effect cholecystectomy NAFLD course. Key findings. The relationship between GD is very complex seems be mutually aggravating. There no doubt there an increased risk GB in patients, which primarily associated with common mechanisms. These include central peripheral insulin resistance, changes expression transcription factors...
Aim of the study. Assessment capacity multiparametric elastography (MPE) in individual selection diffuse liver diseases. Material and methods. A survey 235 patients with diseases: 128 (54,5%) men 107 (45,5%) women. The first group included 64 (27,2%) patient steatogepatitis, second – 97 (41,3%) hepatitis, third 74 (31,5%) cirrhosis liver. Obligatory examination: transient elastography, compression endosonography, shear way elastography. Results. initial examination results diagnostic...
Цель исследования: оценить возможности использования качественных параметров контраст-усиленного ультразвукового исследования (КУУЗИ) для ранней неинвазивной диагностики у пациентов с хроническими вирусными гепатитами (ХВГ).Дизайн: открытое рандомизированное сравнительное исследование
Background: Epidemiological characteristics of chronic hepatitis C virus (HCV) infection presented in the literature are not representative for real situation with its incidence and prevalence Russian Federation. In Moscow Region, which is second largest population Federation (7.2 million people), Regional Registry patients hepatic disorders has been continuously maintained since 2010, as well screening programs anti-HCV positive individuals. Analysis this data allows generalization results...
УДК 616.366-089.87-06 ОСОБЕННОСТИ ТЕЧЕНИЯ ЖЕЛЧНОКАМЕННОЙ БОЛЕЗНИ У ПАЦИЕНТОВ С МЕТАБОЛИЧЕСКИМ СИНДРОМОМ В ПОСТХОЛЕЦИСТЭКТОМИЧЕСКОМ ПЕРИОДЕ1 Лебедева О.В., 1 Иванова А.С., Николаева Т
The article considers the possibility of using telemedicine technologies in providing specialized medical care to patients with chronic hepatitis C and nonalcoholic fatty liver disease. Foreign experience implementation this direction work our own results are presented.
Aim: to evaluate the significance of a positive polymerase chain reaction result for hepatitis D virus RNA (HDV RNA) in liver biopsy specimens patients with chronic (CHD) after completion antiviral therapy (AVT) as predictor infection relapse. Materials and methods . The study included 21 CHD who received combined AVT peginterferon alpha bulevirtide 48 weeks, followed by monotherapy 48–96 making total duration 96–144 weeks. In all HDV became undetectable serum 24–96 weeks from start...
Background. In the last decade, understanding of pathogenesis autoimmune hepatitis (AIH) has significantly deepened, based on results new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens optimized. Materials methods. The latest Russian guidelines for diagnosis treatment AIH were presented in 2013; 2017, first agreement was held. Updating approaches to management patients with necessitated next systematization use practice. February 2024, final...
Aim of the study: evaluate role normalization humoral immunity to address dose reduction or discontinuation immunosuppressors in patients with autoimmune hepatitis (AIH). Patients and methods. The data 47 AIH who received immunosuppressive therapy from April 2001 August 2023 were analyzed: 10 men (21 %), 37 women (79 %); average age was (17–66) years. follow-up period 10–180 months. Type 1 diagnosed patients, type 2 — 7 seronegative 3 patients. diagnosis established according IAIHG point...
Aim. To determine the diagnostic and prognostic value of contrast-enhanced ultrasound (CEUS) in assessment vascular structure liver patients with chronic viral hepatitis.
 Materials methods. Based on Clinical hospital №1 Smolensk from 2018 to 2019 120 people hepatitis 35 unchanged parenchyma as a control group were included study. All examined by CEUS 1,0 ml contrast agent subsequent evaluation qualitative quantitative parameters.
 Results. In statistical data processing it was...
Substantiation : Monitoring adverse events (AEs) among outpatients is an important clinical problem; as they may be the cause of treatment interruption. In this situation; using telemedicine technologies (TMT) rational to prevent these and ensure continuity medical care. The aim study was investigate possibility TMT register AEs unjustified interruption in patients with chronic hepatitis C (CHC); who receiving antiviral therapy (AVT). Methods 84 HCV (genotype 1b) were included study....
Aim: to analyse the principles of diagnosis and treatment intrahepatic cholestasis in chronic liver diseases, present data on effectiveness ademetionine diseases with materials Expert Meeting held 2023. Key points. During Meeting, problems diagnostics various were discussed, was clarified, optimal regimens for its administration determined. The relevance existing algorithm diagnosing real clinical practice assessed. occurring (cholestatic forms drug-induced damage, alcoholic disease,...
While use of high doses alcohol is a proven risk factor for various organs and systems, small moderate bears evidence the opposite data. Thus, regularly drinking amount alcoholic drinks could reduce person’s chances developing coronary heart disease, stroke, type 2 diabetes, non-alcoholic fatty liver osteoporosis some other diseases, also overall mortality. Small suppress inflammation peroxidation, normalize hemocoagulation, improve lipid profile, favourably affect blood vessel tone...
The persistent post-cholecystectomy (CE) symptoms can be divided into four groups: 1) surgical errors; 2) recurrence of cholelithiasis; 3) functional disorders due to removal the gallbladder (transient or persistent); 4) pathology not associated with CE. Biliary pain persists in 20–40% patients after CE, most cases caused by sphincter Oddi dysfunction (SOD). SOD is subdivided biliary, pancreatic, two-duct types, as well pancreatobiliary reflux. rooted increased pressure sphincter, which...