A5012469854- Liver Disease Diagnosis and Treatment
- Neurological Disorders and Treatments
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Heart Rate Variability and Autonomic Control
- Eosinophilic Esophagitis
- Diet and metabolism studies
- IL-33, ST2, and ILC Pathways
- Healthcare Systems and Public Health
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Human Health and Disease
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Aldose Reductase and Taurine
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Biochemical Acid Research Studies
- Diabetes Treatment and Management
- Lipid metabolism and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Apelin-related biomedical research
- Gastrointestinal motility and disorders
- Urticaria and Related Conditions
- Sexual function and dysfunction studies
Volgograd State Medical University
2016-2025
Ministry of Health of the Russian Federation
2015-2021
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According to experts, sarcopenia, as a generalized progressive disorder of skeletal muscle function, will acquire the status global problem in near future, which is associated with an increase human life expectancy, and significance its main phenotypes (sarcopenic obesity, cachexia) beyond doubt. The results meta-analysis indicate that sarcopenic obesity significant predictor all-cause mortality among elderly, especially hospitalized patients. Cachexia cancer. Of particular interest are data...
Aim . The clinical guidelines are intended to provide information support for making decisions by gastroenterologists, general practitioners and internists that will improve the quality of medical care patients with non-alcoholic fatty liver disease, taking into account latest data principles evidence-based medicine. Key points Clinical contain about current views on etiology, risk factors pathogenesis nonalcoholic peculiarities its course. Also given recommendations methods laboratory...
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Introduction . Type 2 diabetes (T2D) increases the risk of developing cardiovascular diseases, which leads to a high mortality in this category patients. Issues regarding prevention onset and progression coronary heart disease (CHD) chronic failure (CHF) patients with T2D and/or metabolic syndrome (MS) are still not fully understood. The use drugs cardioprotective effects, particular Mildronate®, is one possibilities improve effectiveness combination treatment CHD CHF. Aim To study effect...
The article reviews the efficacy of meldonium in patients with various diseases, which are based on secondary mitochondrial dysfunction. Mitochondria complex cellular organelles that control many metabolic processes, including fatty acid oxidation, Krebs cycle, oxidative phosphorylation electron transport chain, and other processes. Many conditions can lead to dysfunction affect diseases. Damage mitochondria promote activation free radical processes initiation mechanisms programmed cell...
Non-alcoholic fatty liver disease (NAFLD) is considered not only as a with poor hepatic prognosis. The problem has acquired multidisciplinary problem. variety of concomitant diseases and pathological conditions are united by common pathophysiological mechanisms. This review summarizes presents the data available in modern literature on association NAFLD cardiovascular diseases, type 2 diabetes mellitus, polycystic ovary syndrome, chronic kidney disease, etc. role homeostasis organism...
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The gut microbiota regulates critical processes in host metabolism and physiology. Understanding the formation of relationships between microbiome, liver, other organs under physiological conditions, as well influence microbiota-damaging factors, provides important insights into pathophysiology not only liver diseases, but also complex level communication role microbiome gut-liver-brain, gut-liver-kidney, gut-liver-lung, gut-liver-heart axes.
Aim. To assess the effect of meldonium (in combination with antihypertensive therapy) on severity asthenic syndrome (AS) in elderly patients arterial hypertension (HT). Material and methods. Patients (n=180, >65 years old) HT (grade 1–2) secondary somatogenic AS (assessed by MFI-20 scale). The were randomized into 3 groups according to scheme treatment. Group 1 — intermittent treatment (500 mg once daily for months followed a break months; 2 courses). continuous 12 months). control (receive...
Epidemiological data suggests that approximately 10-65% of patients with mild to moderate COVID-19 have persistent symptoms already after an acute infection, which may last for six months or more. Previous clinical studies shown similar also occur in the liver. Russian scientists studied phenomenon hyperammonemia phase COVID-19, but problem elevated blood ammonia levels post - COVID syndrome has not been before. One possible option correction is L-ornithine L-aspartate (LOLA) preparation....
The relationship between the formation of non-alcoholic fatty liver disease (NAFLD) in obese individuals has been proven, which increases patient’s cardio-metabolic risk. A number studies have demonstrated that patients with normal body weight (NBW) comparable risks developing cardiovascular and progression to NAFLD compared patients. Purpose study: To assess incidence disorders NBW. Materials methods: 225 both sexes (18–65 years old) confirmed were included. Patients divided into 3 groups...
The number of patients with chronic liver disease (CLD) is steadily increasing. According to the 2023 update published by European Association for Study Liver, diseases account two million deaths annually and 4% all (1 in every 25 worldwide). This review emphasizes need early detection control these course, as a factor that improves patient's prognosis. It proposed use new scale CLivD indicator (Chronic Liver Disease indicator), based on assessment risk factors widely available physician...
To date, nonalcoholic fatty liver disease (NAFLD) is the most common chronic pathology and already at stage of steatosis causes a high risk developing cardiovascular diseases (CVD). Convincing evidence has been obtained that CVD cause death in patients with NAFLD. Common factors (insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, kidney type 2 diabetes mellitus) similar pathophysiological mechanisms (endothelial dysfunction, changes lipid metabolism, systemic inflammation,...
Нeart failure is common both in cardiac and noncardiac disease. We conducted a study that showed high efficacy safety of meldonium patients with heart comorbidity. The ability reduce the severity failure, improve quality life patients, have beneficial effect on lipid carbohydrate metabolism, renal function concomitant diabetes mellitus. Marked positive impact autonomic manifestations neuropathy for diabetic peripheral sensorimotor neuropathy. In addition, use hypertension has cognitive...
This article presents a review of the relationship between visceral obesity and occurrence damage to heart, kidneys, liver.
НЕИНВАЗИВНАЯ ДИАГНОСТИКА НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ: ПРОСТЫЕ «ИНСТРУМЕНТЫ» УЖЕ В РУКАХПРАКТИЧЕСКОГО ВРАЧА
High prevalence of chronic heart failure (CHF) and type 2 diabetes (DM2), poor prognosis low life quality determine the aim for optimum treatment strategy invention. Cornerstone in this category patients is correction endothelial dysfunction metabolism disorders that underlie development progression CHF DM2: lipid- glucose toxicity, insulin resistance (IR). Aim. To study effects taurin as part combination therapy with DM2, taking its influence on dysfunction. Material methods. Totally, 60...